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Volumn 4, Issue MAR, 2013, Pages

Development of CD4 T cell dependent immunity against N. brasiliensis infection

Author keywords

CD4 Th2; Helminth; Protective immunity; Regulation

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 25; INTERLEUKIN 33; INTERLEUKIN 4; STAT6 PROTEIN;

EID: 84883746340     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00074     Document Type: Review
Times cited : (20)

References (43)
  • 1
    • 4544300682 scopus 로고    scopus 로고
    • RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
    • U.S.A.
    • Artis, D., Wang, M. L., Keilbaugh, S. A., He, W., Brenes, M., Swain, G. P., et al. (2004). RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc. Natl. Acad. Sci. U.S.A. 101, 13596-13600.
    • (2004) Proc. Natl. Acad. Sci. , vol.101 , pp. 13596-13600
    • Artis, D.1    Wang, M.L.2    Keilbaugh, S.A.3    He, W.4    Brenes, M.5    Swain, G.P.6
  • 2
    • 44649133452 scopus 로고    scopus 로고
    • Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus
    • Chapter 19, Unit 19 12
    • Camberis, M., Le Gros, G., and Urban, J. Jr. (2003). Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus. Curr. Protoc. Immunol. Chapter 19, Unit 19 12.
    • (2003) Curr. Protoc. Immunol.
    • Camberis, M.1    Le Gros, G.2    Urban Jr, J.3
  • 3
    • 0025338921 scopus 로고
    • Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells
    • Conrad, D. H., Ben-Sasson, S. Z., Le Gros, G., Finkelman, F. D., and Paul, W. E. (1990). Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells. J. Exp. Med. 171, 1497-1508.
    • (1990) J. Exp. Med. , vol.171 , pp. 1497-1508
    • Conrad, D.H.1    Ben-Sasson, S.Z.2    Le Gros, G.3    Finkelman, F.D.4    Paul, W.E.5
  • 4
    • 0032830632 scopus 로고    scopus 로고
    • Trapping and immobilization of Nippostrongylus brasiliensis larvae at the site of inoculation in primary infections of interleukin-5 transgenic mice
    • Daly, C. M., Mayrhofer, G., and Dent, L. A. (1999). Trapping and immobilization of Nippostrongylus brasiliensis larvae at the site of inoculation in primary infections of interleukin-5 transgenic mice. Infect. Immun. 67, 5315-5323.
    • (1999) Infect. Immun. , vol.67 , pp. 5315-5323
    • Daly, C.M.1    Mayrhofer, G.2    Dent, L.A.3
  • 5
    • 33645888708 scopus 로고    scopus 로고
    • Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    • Fallon, P. G., Ballantyne, S. J., Mangan, N. E., Barlow, J. L., Dasvarma, A., Hewett, D. R., et al. (2006). Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J. Exp. Med. 203, 1105-1116.
    • (2006) J. Exp. Med. , vol.203 , pp. 1105-1116
    • Fallon, P.G.1    Ballantyne, S.J.2    Mangan, N.E.3    Barlow, J.L.4    Dasvarma, A.5    Hewett, D.R.6
  • 6
    • 0036337768 scopus 로고    scopus 로고
    • IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13
    • Fallon, P. G., Jolin, H. E., Smith, P., Emson, C. L., Townsend, M. J., Fallon, R., et al. (2002). IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. Immunity 17, 7-17.
    • (2002) Immunity , vol.17 , pp. 7-17
    • Fallon, P.G.1    Jolin, H.E.2    Smith, P.3    Emson, C.L.4    Townsend, M.J.5    Fallon, R.6
  • 8
    • 4844221210 scopus 로고    scopus 로고
    • Interleukin-4-and interleukin-13-mediated host protection against intestinal nematode parasites
    • Finkelman, F. D., Shea-Donohue, T., Morris, S. C., Gildea, L., Strait, R., Madden, K. B., et al. (2004). Interleukin-4-and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol. Rev. 201, 139-155.
    • (2004) Immunol. Rev. , vol.201 , pp. 139-155
    • Finkelman, F.D.1    Shea-Donohue, T.2    Morris, S.C.3    Gildea, L.4    Strait, R.5    Madden, K.B.6
  • 9
    • 29244484753 scopus 로고    scopus 로고
    • Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs
    • Fujiwara, R. T., Loukas, A., Mendez, S., Williamson, A. L., Bueno, L. L., Wang, Y., et al. (2006). Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs. Vaccine 24, 501-509.
    • (2006) Vaccine , vol.24 , pp. 501-509
    • Fujiwara, R.T.1    Loukas, A.2    Mendez, S.3    Williamson, A.L.4    Bueno, L.L.5    Wang, Y.6
  • 10
    • 12244275041 scopus 로고    scopus 로고
    • Successful vaccination of BALB/c mice against human hookworm (Necator americanus): the immunological phenotype of the protective response
    • Girod, N., Brown, A., Pritchard, D. I., and Billett, E. E. (2003). Successful vaccination of BALB/c mice against human hookworm (Necator americanus): the immunological phenotype of the protective response. Int. J. Parasitol. 33, 71-80.
    • (2003) Int. J. Parasitol. , vol.33 , pp. 71-80
    • Girod, N.1    Brown, A.2    Pritchard, D.I.3    Billett, E.E.4
  • 11
    • 0037017383 scopus 로고    scopus 로고
    • Differential T cell function and fate in lymph node and nonlymphoid tissues
    • Harris, N. L., Watt, V., Ronchese, F., and Le Gros, G. (2002). Differential T cell function and fate in lymph node and nonlymphoid tissues. J. Exp. Med. 195, 317-326.
    • (2002) J. Exp. Med. , vol.195 , pp. 317-326
    • Harris, N.L.1    Watt, V.2    Ronchese, F.3    Le Gros, G.4
  • 12
    • 77956641353 scopus 로고    scopus 로고
    • The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites
    • Harvie, M., Camberis, M., Tang, S. C., Delahunt, B., Paul, W., and Le Gros, G. (2010). The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites. Infect. Immun. 78, 3753-3762.
    • (2010) Infect. Immun. , vol.78 , pp. 3753-3762
    • Harvie, M.1    Camberis, M.2    Tang, S.C.3    Delahunt, B.4    Paul, W.5    Le Gros, G.6
  • 13
    • 73949086150 scopus 로고    scopus 로고
    • Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection
    • Herbert, D. R., Yang, J. Q., Hogan, S. P., Groschwitz, K., Khodoun, M., Munitz, A., et al. (2009). Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J. Exp. Med. 206, 2947-2957.
    • (2009) J. Exp. Med. , vol.206 , pp. 2947-2957
    • Herbert, D.R.1    Yang, J.Q.2    Hogan, S.P.3    Groschwitz, K.4    Khodoun, M.5    Munitz, A.6
  • 14
    • 10044219679 scopus 로고    scopus 로고
    • Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related receptors
    • Holland, M. J., Harcus, Y. M., Balic, A., and Maizels, R. M. (2005). Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related receptors. Immunol. Lett. 96, 93-101.
    • (2005) Immunol. Lett. , vol.96 , pp. 93-101
    • Holland, M.J.1    Harcus, Y.M.2    Balic, A.3    Maizels, R.M.4
  • 15
    • 0033922732 scopus 로고    scopus 로고
    • Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses
    • Holland, M. J., Harcus, Y. M., Riches, P. L., and Maizels, R. M. (2000). Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses. Eur. J. Immunol. 30, 1977-1987.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1977-1987
    • Holland, M.J.1    Harcus, Y.M.2    Riches, P.L.3    Maizels, R.M.4
  • 16
    • 0035122901 scopus 로고    scopus 로고
    • Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene
    • Hu-Li, J., Pannetier, C., Guo, L., Lohning, M., Gu, H., Watson, C., et al. (2001). Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene. Immunity 14, 1-11.
    • (2001) Immunity , vol.14 , pp. 1-11
    • Hu-Li, J.1    Pannetier, C.2    Guo, L.3    Lohning, M.4    Gu, H.5    Watson, C.6
  • 17
    • 84872003060 scopus 로고    scopus 로고
    • IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms
    • U.S.A.
    • Hung, L. Y., Lewkowich, I. P., Dawson, L. A., Downey, J., Yang, Y., Smith, D. E., et al. (2012). IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms. Proc. Natl. Acad. Sci. U.S.A. 110, 282-287.
    • (2012) Proc. Natl. Acad. Sci. , vol.110 , pp. 282-287
    • Hung, L.Y.1    Lewkowich, I.P.2    Dawson, L.A.3    Downey, J.4    Yang, Y.5    Smith, D.E.6
  • 18
    • 0023913458 scopus 로고
    • The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis
    • Katona, I. M., Urban, J. F. Jr., and Finkelman, F. D. (1988). The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis. J. Immunol. 140, 3206-3211.
    • (1988) J. Immunol. , vol.140 , pp. 3206-3211
    • Katona, I.M.1    Urban Jr., J.F.2    Finkelman, F.D.3
  • 19
    • 77249158040 scopus 로고    scopus 로고
    • Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3
    • Kim, S., Prout, M., Ramshaw, H., Lopez, A. F., Legros, G., and Min, B. (2010). Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3. J. Immunol. 184, 1143-1147.
    • (2010) J. Immunol. , vol.184 , pp. 1143-1147
    • Kim, S.1    Prout, M.2    Ramshaw, H.3    Lopez, A.F.4    Legros, G.5    Min, B.6
  • 20
    • 58749098258 scopus 로고    scopus 로고
    • FVB/N mice are highly resistant to primary infection with Nippostrongylus brasiliensis
    • Knott, M. L., Hogan, S. P., Wang, H., Matthaei, K. I., and Dent, L. A. (2009). FVB/N mice are highly resistant to primary infection with Nippostrongylus brasiliensis. Parasitology 136, 93-106.
    • (2009) Parasitology , vol.136 , pp. 93-106
    • Knott, M.L.1    Hogan, S.P.2    Wang, H.3    Matthaei, K.I.4    Dent, L.A.5
  • 21
    • 34548047670 scopus 로고    scopus 로고
    • Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis
    • Knott, M. L., Matthaei, K. I., Giacomin, P. R., Wang, H., Foster, P. S., and Dent, L. A. (2007). Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis. Int. J. Parasitol. 37, 1367-1378.
    • (2007) Int. J. Parasitol. , vol.37 , pp. 1367-1378
    • Knott, M.L.1    Matthaei, K.I.2    Giacomin, P.R.3    Wang, H.4    Foster, P.S.5    Dent, L.A.6
  • 22
  • 23
    • 0030272482 scopus 로고    scopus 로고
    • Nippostrongylus brasiliensis: cytokine responses and nematode expulsion in normal and IL-4-deficient mice
    • Lawrence, R. A., Gray, C. A., Osborne, J., and Maizels, R. M. (1996). Nippostrongylus brasiliensis: cytokine responses and nematode expulsion in normal and IL-4-deficient mice. Exp. Parasitol. 84, 65-73.
    • (1996) Exp. Parasitol. , vol.84 , pp. 65-73
    • Lawrence, R.A.1    Gray, C.A.2    Osborne, J.3    Maizels, R.M.4
  • 24
    • 0025082313 scopus 로고
    • Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells
    • Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D., and Paul, W. E. (1990). Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172, 921-929.
    • (1990) J. Exp. Med. , vol.172 , pp. 921-929
    • Le Gros, G.1    Ben-Sasson, S.Z.2    Seder, R.3    Finkelman, F.D.4    Paul, W.E.5
  • 25
    • 0023252329 scopus 로고
    • Concomitant immunoglobulin E and immunoglobulin G1 formation in Nippostrongylus brasiliensis-infected mice
    • Lebrun, P., and Spiegelberg, H. L. (1987). Concomitant immunoglobulin E and immunoglobulin G1 formation in Nippostrongylus brasiliensis-infected mice. J. Immunol. 139, 1459-1465.
    • (1987) J. Immunol. , vol.139 , pp. 1459-1465
    • Lebrun, P.1    Spiegelberg, H.L.2
  • 26
    • 0037114183 scopus 로고    scopus 로고
    • Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo
    • Liu, Z., Liu, Q., Pesce, J., Whitmire, J., Ekkens, M. J., Foster, A., et al. (2002). Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo. J. Immunol. 169, 6959-6968.
    • (2002) J. Immunol. , vol.169 , pp. 6959-6968
    • Liu, Z.1    Liu, Q.2    Pesce, J.3    Whitmire, J.4    Ekkens, M.J.5    Foster, A.6
  • 27
    • 42249093361 scopus 로고    scopus 로고
    • Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages
    • Marsland, B. J., Kurrer, M., Reissmann, R., Harris, N. L., and Kopf, M. (2008). Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages. Eur. J. Immunol. 38, 479-488.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 479-488
    • Marsland, B.J.1    Kurrer, M.2    Reissmann, R.3    Harris, N.L.4    Kopf, M.5
  • 28
    • 69549135695 scopus 로고    scopus 로고
    • Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function
    • U.S.A.
    • Massacand, J. C., Stettler, R. C., Meier, R., Humphreys, N. E., Grencis, R. K., Marsland, B. J., et al. (2009). Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function. Proc. Natl. Acad. Sci. U.S.A. 106, 13968-13973.
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , pp. 13968-13973
    • Massacand, J.C.1    Stettler, R.C.2    Meier, R.3    Humphreys, N.E.4    Grencis, R.K.5    Marsland, B.J.6
  • 29
    • 4344647601 scopus 로고    scopus 로고
    • Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite
    • Min, B., Prout, M., Hu-Li, J., Zhu, J., Jankovic, D., Morgan, E. S., et al. (2004). Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J. Exp. Med. 200, 507-517.
    • (2004) J. Exp. Med. , vol.200 , pp. 507-517
    • Min, B.1    Prout, M.2    Hu-Li, J.3    Zhu, J.4    Jankovic, D.5    Morgan, E.S.6
  • 30
    • 26644448473 scopus 로고    scopus 로고
    • A two-step process for cytokine production revealed by IL-4 dual-reporter mice
    • Mohrs, K., Wakil, A. E., Killeen, N., Locksley, R. M., and Mohrs, M. (2005). A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity 23, 419-429.
    • (2005) Immunity , vol.23 , pp. 419-429
    • Mohrs, K.1    Wakil, A.E.2    Killeen, N.3    Locksley, R.M.4    Mohrs, M.5
  • 31
    • 0034877815 scopus 로고    scopus 로고
    • Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter
    • Mohrs, M., Shinkai, K., Mohrs, K., and Locksley, R. M. (2001). Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 15, 303-311.
    • (2001) Immunity , vol.15 , pp. 303-311
    • Mohrs, M.1    Shinkai, K.2    Mohrs, K.3    Locksley, R.M.4
  • 32
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    • Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M., Langford, T. K., et al. (2010). Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464, 1367-1370.
    • (2010) Nature , vol.464 , pp. 1367-1370
    • Neill, D.R.1    Wong, S.H.2    Bellosi, A.3    Flynn, R.J.4    Daly, M.5    Langford, T.K.6
  • 33
    • 67649229687 scopus 로고    scopus 로고
    • MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity
    • Perrigoue, J. G., Saenz, S. A., Siracusa, M. C., Allenspach, E. J., Taylor, B. C., Giacomin, P. R., et al. (2009). MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat. Immunol. 10, 697-705.
    • (2009) Nat. Immunol. , vol.10 , pp. 697-705
    • Perrigoue, J.G.1    Saenz, S.A.2    Siracusa, M.C.3    Allenspach, E.J.4    Taylor, B.C.5    Giacomin, P.R.6
  • 36
    • 77951817294 scopus 로고    scopus 로고
    • IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses
    • Saenz, S. A., Siracusa, M. C., Perrigoue, J. G., Spencer, S. P., Urban, J. F. Jr., Tocker, J. E., et al. (2010). IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature 464, 1362-1366.
    • (2010) Nature , vol.464 , pp. 1362-1366
    • Saenz, S.A.1    Siracusa, M.C.2    Perrigoue, J.G.3    Spencer, S.P.4    Urban Jr., J.F.5    Tocker, J.E.6
  • 37
    • 80052450261 scopus 로고    scopus 로고
    • Protective immunity against the gastrointestinal nematode Nippostrongylus brasiliensis requires a broad T-cell receptor repertoire
    • Seidl, A., Panzer, M., and Voehringer, D. (2011). Protective immunity against the gastrointestinal nematode Nippostrongylus brasiliensis requires a broad T-cell receptor repertoire. Immunology 134, 214-223.
    • (2011) Immunology , vol.134 , pp. 214-223
    • Seidl, A.1    Panzer, M.2    Voehringer, D.3
  • 38
    • 0033933919 scopus 로고    scopus 로고
    • T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis
    • Senn, K. A., Mccoy, K. D., Maloy, K. J., Stark, G., Frohli, E., Rulicke, T., et al. (2000). T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis. Eur. J. Immunol. 30, 1929-1938.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1929-1938
    • Senn, K.A.1    Mccoy, K.D.2    Maloy, K.J.3    Stark, G.4    Frohli, E.5    Rulicke, T.6
  • 40
    • 39449133957 scopus 로고    scopus 로고
    • A mechanism for the initiation of allergen-induced T helper type 2 responses
    • Sokol, C. L., Barton, G. M., Farr, A. G., and Medzhitov, R. (2008). A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol. 9, 310-318.
    • (2008) Nat. Immunol. , vol.9 , pp. 310-318
    • Sokol, C.L.1    Barton, G.M.2    Farr, A.G.3    Medzhitov, R.4
  • 41
    • 0032007351 scopus 로고    scopus 로고
    • IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
    • Urban, J. F. Jr., Noben-Trauth, N., Donaldson, D. D., Madden, K. B., Morris, S. C., Collins, M., et al. (1998). IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8, 255-264.
    • (1998) Immunity , vol.8 , pp. 255-264
    • Urban Jr., J.F.1    Noben-Trauth, N.2    Donaldson, D.D.3    Madden, K.B.4    Morris, S.C.5    Collins, M.6
  • 42
    • 50449101434 scopus 로고    scopus 로고
    • In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation
    • U.S.A.
    • van Panhuys, N., Tang, S. C., Prout, M., Camberis, M., Scarlett, D., Roberts, J., et al. (2008). In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation. Proc. Natl. Acad. Sci. U.S.A. 105, 12423-12428.
    • (2008) Proc. Natl. Acad. Sci. , vol.105 , pp. 12423-12428
    • van Panhuys, N.1    Tang, S.C.2    Prout, M.3    Camberis, M.4    Scarlett, D.5    Roberts, J.6
  • 43
    • 33745036694 scopus 로고    scopus 로고
    • Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
    • Voehringer, D., Reese, T. A., Huang, X., Shinkai, K., and Locksley, R. M. (2006). Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J. Exp. Med. 203, 1435-1446.
    • (2006) J. Exp. Med. , vol.203 , pp. 1435-1446
    • Voehringer, D.1    Reese, T.A.2    Huang, X.3    Shinkai, K.4    Locksley, R.M.5


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