Mapping of low molecular weight heparins using reversed phase ion pair liquid chromatography-mass spectrometry

Carbohydrate Polymers

Volumn 99, Issue , 2014, Pages 339-344

  Chi, Lianli ^a   Li, Daoyuan ^a   Chi, Lequan ^b   Jin, Lan ^a   Xu, Xiaohui ^a   Du, Xuzhao ^c   Ji, Shengli ^a,c  

^a SHANDONG UNIVERSITY   (China)

^b OCEAN UNIVERSITY OF CHINA   (China)

^c Hebei Changshan Biochemical Pharmaceutical Co Ltd   (China)

Author keywords

Chain mapping; Low molecular weight heparin; Mass spectrometry; Reversed phase ion pair

Indexed keywords

ELECTROSPRAY IONIZATION MASS SPECTROMETRY; ION PAIRS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LOW MOLECULAR WEIGHT HEPARIN (LMWHS); LOW-MOLECULAR WEIGHT HEPARINS; PROCESS-RELATED IMPURITIES; STRUCTURAL CHARACTERIZATION; STRUCTURE CHARACTERIZATION;

BIOCHEMISTRY; CHAINS; DRUG INTERACTIONS; DRUG PRODUCTS; MASS SPECTROMETRY; MOLECULAR WEIGHT; QUALITY ASSURANCE;

POLYSACCHARIDES;

ANTICOAGULANT AGENT; ENOXAPARIN; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN;

ANIMAL; ARTICLE; CARBOHYDRATE ANALYSIS; CHAIN MAPPING; CHEMISTRY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; MOLECULAR GENETICS; REVERSED PHASE ION PAIR; REVERSED PHASE LIQUID CHROMATOGRAPHY; SWINE;

CHAIN MAPPING; LOW MOLECULAR WEIGHT HEPARIN; MASS SPECTROMETRY; REVERSED PHASE ION PAIR;

ANIMALS; ANTICOAGULANTS; CARBOHYDRATE SEQUENCE; CHROMATOGRAPHY, REVERSE-PHASE; ENOXAPARIN; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; NADROPARIN; SWINE;

EID: 84883706414     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2013.08.074     Document Type: Article

References (23)

1. L. Chi, J.J. Wolff, T.N. Laremore, O.F. Restaino, J. Xie, and C. Schiraldi Structural analysis of bikunin glycosaminoglycan Journal of the American Chemical Society 130 2008 2617 2625
2. B. Cosmi, and G. Palareti Old and new heparins Thrombosis Research 129 2012 388 391
3. C.E. Doneanu, W. Chen, and J.C. Gebler Analysis of oligosaccharides derived from heparin by ion-pair reversed-phase chromatography/mass spectrometry Analytical Chemistry 81 2009 3485 3499
4. M. Guerrini, D. Beccati, Z. Shriver, A. Naggi, K. Viswanathan, and A. Bisio Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events Nature Biotechnology 26 2008 669 675
5. J. Harenberg Overview on guidelines and recommendations for generic low-molecular-weight heparins Thrombosis Research 127 Suppl. 3 2011 S100 S104
6. J. Henriksen, P. Roepstorff, and L.H. Ringborg Ion-pairing reversed-phased chromatography/mass spectrometry of heparin Carbohydrate Research 341 2006 382 387
7. K. Higashi, S. Hosoyama, A. Ohno, S. Masuko, B. Yang, and E. Sterner Photochemical preparation of a novel low molecular weight heparin Carbohydrate Polymers 67 2012 1737 1743
8. D.J. Langeslay, E. Urso, C. Gardini, A. Naggi, G. Torri, and C.K. Larive Reversed-phase ion-pair ultra-high-performance-liquid chromatography-mass spectrometry for fingerprinting low-molecular-weight heparins Journal of Chromatography A 1292 2013 201 210
9. S. Lee, A. Raw, L. Yu, R. Lionberger, N. Ya, and D. Verthelyi Scientific considerations in the review and approval of generic enoxaparin in the United States Nature Biotechnology 31 2013 220 226
10. L. Li, F. Zhang, J. Zaia, and R.J. Linhardt Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS Analytical Chemistry 84 2012 8822 8829
11. R.J. Linhardt, K.G. Rice, Y.S. Kim, D.L. Lohse, H.M. Wang, and D. Loganathan Mapping and quantification of the major oligosaccharide components of heparin The Biochemical Journal 254 1988 781 787
12. R.J. Linhardt, and J. Liu Synthetic heparin Current Opinion in Pharmacology 12 2012 217 219
13. M. Ly, F.E. Leach 3rd, T.N. Laremore, T. Toida, I.J. Amster, and R.J. Linhardt The proteoglycan bikunin has a defined sequence Nature Chemical Biology 7 2011 827 833
14. E. Maxwell, Y. Tan, Y. Tan, H. Hu, G. Benson, and K. Aizikov GlycReSoft: a software package for automated recognition of glycans from LC/MS data PLoS ONE 7 2012 e45474
15. P.A. Mourier, and C. Viskov Chromatographic analysis and sequencing approach of heparin oligosaccharides using cetyltrimethylammonium dynamically coated stationary phases Analytical Biochemistry 332 2004 299 313
16. R.P. Patel, C. Narkowicz, J.P. Hutchinson, E.F. Hilder, and G.A. Jacobson A simple capillary electrophoresis method for the rapid separation and determination of intact low molecular weight and unfractionated heparins Journal of Pharmaceutical and Biomedical Analysis 46 2008 30 35
17. R.P. Patel, C. Narkowicz, and G.A. Jacobson Effective reversed-phase ion pair high-performance liquid chromatography method for the separation and characterization of intact low-molecular-weight heparins Analytical Biochemistry 387 2009 113 121
18. C. Thanawiroon, K.G. Rice, T. Toida, and R.J. Linhardt Liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides The Journal of Biological Chemistry 23 2004 2608 2615
19. G. Venkataraman, Z. Shriver, R. Raman, and R. Sasisekharan Sequencing complex polysaccharides Science 286 1999 537 542
20. N. Volpi, F. Maccari, J. Suwan, and R.J. Linhardt Electrophoresis for the analysis of heparin purity and quality Electrophoresis 33 2012 1531 1537
21. J.I. Weitz Low-molecular-weight heparins The New England Journal of Medicine 337 1997 688 699
22. Q. Zhang, X. Chen, Z. Zhu, X. Zhan, Y. Wu, and L. Song Structural analysis of low molecular weight heparin by ultra performance size exclusion chromatography/time of flight mass spectrometry and capillary zone electrophoresis Analytical Chemistry 85 2013 1819 1827
23. X. Zhao, B. Yang, L. Li, F. Zhang, and R.J. Linhardt On-line separation and characterization of hyaluronan oligosaccharides derived from radical depolymerization Carbohydrate Polymers 96 2013 503 509