Association of the brain-derived neurotrophic factor gene G196A rs6265 polymorphisms and the cognitive function and clinical symptoms of schizophrenia

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 8, 2013, Pages 1617-1623

  Zhai, Jinguo ^a   Yu, Qing ^a   Chen, Min ^a   Gao, Yan ^a   Zhang, Qiumei ^a   Li, Jun ^b   Wang, Keqin ^a   Ji, Feng ^a   Su, Zhonghua ^a   Li, Wu ^a   Li, Xuemei ^a   Qiao, Juyao ^a  

^a JINING MEDICAL UNIVERSITY   (China)

^b BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Brain derived neurotrophic factor; Cognitive function; G196A gene; Molecular psychiatry; Schizophrenia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR, HUMAN; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

ADULT; ARTICLE; COGNITION; FEMALE; G196A GENE; GENETICS; GENOTYPE; HUMAN; MALE; MOLECULAR PSYCHIATRY; NEUROPSYCHOLOGICAL TEST; NEWBORN; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITIVE FUNCTION; G196A GENE; MOLECULAR PSYCHIATRY; SCHIZOPHRENIA;

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION; FEMALE; GENOTYPE; HUMANS; INFANT, NEWBORN; MALE; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHIZOPHRENIA;

EID: 84883681702     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Yin DM, Chen YJ, Sathyamurthy A, Xiong WC, Mei L. Synaptic dysfunction in schizophrenia. Adv Exp Med Biol 2012; 970: 493-516.
2. Ho BC, Milev P, O'Leary DS, Librant A, Andreasen NC, Wassink TH. Cognitive and Magnetic Resonance Imaging Brain Morphometric Correlates of Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism in Patients With Schizophrenia and Healthy Volunteers. Arch Gen Psychiatry 2006; 63: 731-740.
3. Craddock N, O'Donovan MC, Owen MJ. Genes for Schizophrenia and Bipolar Disorder? Implications for Psychiatric Nosology. Schizophr Bull 2006; 32: 9-16.
4. Zintzaras E. Brain-derived neurotrophic factor gene polymorphisms and schizophrenia: a meta-analysis. Psychiatr Genet 2007; 17: 69-75.
5. Carlino D, Leone E, Di Cola F, Baj G, Marin R, Dinelli G, Tongiorgi E, De Vanna M. Low serum truncated-BDNF isoform correlates with higher cognitive impairment in schizophrenia. J Psychiatr Res 2011; 45: 273-279.
6. Snigdha S, Neill JC, McLean SL, Shemar GK, Cruise L, Shahid M, Henry B. Phencyclidine (PCP)-induced disruption in cognitive performance is gender-specific and associated with a reduction in brain-derived neurotrophic factor (BDNF) in specific regions of the female rat brain. J Mol Neurosci 2011; 43: 337-345.
7. Wang L, Ashley-Koch A, Steffens DC, Krishnan KR, Taylor WD. Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function. Genes Brain Behav 2012; 11: 352-9.doi: 10.1111/j.1601-183X.2012.00764.x.
8. Kanazawa T, Glatt SJ, Kia-Keating B, Yoneda H, Tsuang MT. Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder. Psychiatr Genet 2007; 17: 165-170.
9. Xu MQ, St Clair D, Ott J, Feng GY, He L. Brain-derived neurotrophic factor gene C-270T and Val66Met functional polymorphisms and risk of schizophrenia: a moderate-scale population-based study and meta-analysis. Schizophr Res 2007; 91: 6-13.
10. Gratacòs M, González JR, Mercader JM, De Cid R, Urretavizcaya M, Estivill X. Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol Psychiatry 2007; 61: 911-922.
11. Qian L, Zhao J, Shi Y, Zhao X, Feng G, Xu F, Zhu S, He L. Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis. Biochem Biophys Res Commun 2007; 353: 738-743.
12. Kanazawa T, Glatt SJ, Kia-Keating B, Yoneda H, Tsuang MT. Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder. Psychiatr Genet 2007; 17: 165-170.
13. Guilera G, Pino O, Gómez-Benito J, Rojo JE. Neurocognition in schizophrenia: A study of the productivity and visibility of Spanish authors. Psicothema 2012; 24: 22-28.
14. Kaneda Y, Ueoka Y, Sumiyoshi T, Yasui-Furukori N, Ito T, Higuchi Y, Suzuki M, Ohmori T. Schizophrenia Cognition Rating Scale Japanese version (SCoRS-J) as a co-primary measure assessing cognitive function in schizophrenia. Nihon Shinkei Seishin Yakurigaku Zasshi 2011; 31: 259-262.
15. Howes OD, Fusar-Poli P, Bloomfield M, Selvaraj S, McGuire P. From the prodrome to chronic schizophrenia: the neurobiology underlying psychotic symptoms and cognitive impairments. Curr Pharm Des 2012; 18: 459-465.
16. Deserno L, Sterzer P, Wüstenberg T, Heinz A, Schlagenhauf F. Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia. J Neurosci 2012; 32: 12-20.
17. Pillai A, Kale A, Joshi S, Naphade N, Raju MS, Nasrallah H, Mahadik SP. Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: correlation with plasma BDNF and psychopathology. Int J Neuropsychopharmacol 2010; 13: 535-539.
18. OliéJP, Mouaffak F, Krebs MO, Lôo H. Schizophrenia, a neurodevelopmental illness. Ann Pharm Fr 2009; 67: 251-255.
19. Chakraborty G, Magagna-Poveda A, Parratt C, Umans JG, Maclusky NJ, Scharfman HE. Reduced Hippocampal Brain-Derived Neurotrophic Factor (BDNF) in Neonatal Rats after Prenatal Exposure to Propylthiouracil (PTU). Endocrinology 2012; 153: 1311-1316.
20. Ertugrul A, Ozdemir H, Vural A, Dalkara T, Meltzer HY, Saka E. The influence of N-desmethylclozapine and clozapine on recognition memory and BDNF expression in hippocampus. Brain Res Bull 2011; 84: 144-150.
21. Egan MF, Weinberger DR, Lu B. Schizophrenia, III: brain-derived neurotropic factor and genetic risk. Am J Psychiatry 2003; 160: 1242.
22. Mandelman SD, Grigorenko EL. BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association. Genes Brain Behav 2012; 11: 127-36. doi: 10.1111/j.1601- 183X.2011.00738.x.
23. Huang TL, Lee CT. Associations between brain-derived neurotrophic factor G196A gene polymorphism and clinical phenotypes in schizophrenia patients. Chang Gung Med J 2007; 30: 408-413.
24. Wang Y, Wang JD, Wu HR, Zhang BS, Fang H, Ma QM, Liu H, Chen da C, Xiu MH, Hail CN, Kosten TR, Zhang XY. The Val66Met polymorphism of the brain-derived neurotrophic factor gene is not associated with risk for schizophrenia and tardive dyskinesia in Han Chinese population. Schizophr Res 2010; 120: 240-242.
25. Sun RF, Zhu YS, Kuang WJ, Liu Y, Li SB. The G-712A polymorphism of brain-derived neuro trophic factor is associated with major depression but not schizophrenia. Neurosci Lett 2011; 489: 34-37.
26. Xu MQ, St Clair D, Feng GY, Lin ZG, He G, Li X, He L. BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population. Pharmacogenet Genomics 2008; 18: 449-457.
27. Xu MQ, St Clair D, Ott J, Feng GY, He L. Brain-derived neurotrophic factor gene C-270T and Val66Met functional polymorphisms and risk of schizophrenia: a moderate-scale population-based study and meta-analysis. Schizophr Res 2007; 91: 6-13.
28. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261-276.
29. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. Effi ciency and power in genetic association studies. Nat Genet 2005; 37: 1217-1223.
30. Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. Neurobiology of schizophrenia. Neuron 2006; 52: 139-153.
31. Buonanno A. The neuregulin signaling pathway and schizophrenia: from genes to synapses and neural circuits. Brain Res Bull 2010; 83: 122-131.
32. Shen YC, Tsai HM, Ruan JW, Liao YC, Chen SF, Chen CH. Genetic and functional analyses of the gene encoding neurogranin in schizophrenia. Schizophr Res 2012; 137: 7-13. doi: 10.1016 /j.schres.2012.01.011.
33. Muglia P, Vincente AM, Verga M, King N, Macciardi F, Kennedy JL. Association between the BDNF gene and schizophrenia. Mol Psychiatry 2003; 8: 147-148.
34. Hong CJ, Yu YW, Lin CH, Tsai SJ. An association study of a BDNF Val66Met polymorphism and clozapine response of schizophrenic patients. Neurosci Lett 2003; 349: 206-208.
35. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112: 257-269.
36. Skibinska M, Hauser J, Czerski PM, Leszczynska-Rodziewicz A, Kosmowska M, Kapelski P, Slopien A, Zakrzewska M, Rybakowski JK. Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. World J Biol Psychiatry 2004; 5: 215-220.
37. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998; 12: 426-445.
38. Anttila S, Illi A, Kampman O, Mattila KM, Lehtimäki T, Leinonen E. Lack of association between two polymorphisms of brain-derived neurotrophic factor and response to typical neuroleptics. J Neural Transm 2005; 112: 885-890.