Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest

Critical Care Medicine

Volumn 41, Issue 9, 2013, Pages 2116-2124

  Arola, Olli J ^a   Laitio, Ruut M ^a   Roine, Risto O ^a   Grönlund, Juha ^a   Saraste, Antti ^a   Pietilä, Mikko ^a   Airaksinen, Juhani ^a   Perttilä, Juha ^a   Scheinin, Harry ^a   Olkkola, Klaus T ^a   Maze, Mervyn ^b   Laitio, Timo T ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cardiac arrest; cardiopulmonary resuscitation; hypothermia; myocardial ischemia; ventricular fibrillation; xenon

Indexed keywords

C REACTIVE PROTEIN; NORADRENALIN; TROPONIN T; XENON;

ACUTE KIDNEY FAILURE; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ARTICLE; BLEEDING; BRADYCARDIA; CLINICAL ARTICLE; CONTROLLED STUDY; EPILEPTIC STATE; FEMALE; FIRST DEGREE ATRIOVENTRICULAR BLOCK; HEART CONDUCTION; HEART FAILURE; HEART RATE; HEART REPOLARIZATION; HEART RHYTHM; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HOSPITALIZATION; HUMAN; INDUCED HYPOTHERMIA; INHALATION; LEUKOCYTE COUNT; LUNG EDEMA; MALE; MORTALITY; OPEN STUDY; OUT OF HOSPITAL CARDIAC ARREST; PATIENT MONITORING; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; STENT THROMBOSIS; THROMBOCYTE COUNT;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARDIOPULMONARY RESUSCITATION; FEASIBILITY STUDIES; FEMALE; HOSPITAL MORTALITY; HUMANS; HYPOTHERMIA, INDUCED; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; OUT-OF-HOSPITAL CARDIAC ARREST; XENON; YOUNG ADULT;

EID: 84883657663     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31828a4337     Document Type: Article

References (36)

1. Arrich J, Holzer M, Herkner H, et al: Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database of Systematic Reviews 2009; CD004128
2. Dumas F, Grimaldi D, Zuber B, et al: Is hypothermia after cardiac arrest effective in both shockable and nonshockable patients?: insights from a large registry. Circulation 2011; 123:877-886
3. Neumar RW, Nolan JP, Adrie C, et al: Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 2008; 118:2452-2483
4. Laver S, Farrow C, Turner D, et al: Mode of death after admission to an intensive care unit following cardiac arrest. Intensive Care Med 2004; 30:2126-2128
5. Hypothermia After Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346:549-556.
6. Nielsen N, Wetterslev J, al-Subaie N, et al: Target temperature management after out-of-hospital cardiac arrest-a randomized, parallelgroup, assessor-blinded clinical trial-rationale and design. Am Heart J 2012; 163:541-548
7. Franks NP, Dickinson R, de Sousa SL, et al: How does xenon produce anaesthesia? Nature 1998; 396:324
8. Wilhelm S, Ma D, Maze M, et al: Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology 2002; 96:1485-1491
9. Ma D, Yang H, Lynch J, et al: Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology 2003; 98:690-698
10. Homi HM, Yokoo N, Ma D, et al: The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Anesthesiology 2003; 99:876-881
11. Schmidt M, Marx T, Glöggl E, et al: Xenon attenuates cerebral damage after ischemia in pigs. Anesthesiology 2005; 102:929-936
12. Dingley J, Tooley J, Porter H, et al: Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxia-ischemia. Stroke 2006; 37:501-506
13. Ma D, Hossain M, Chow A, et al: Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol 2005; 58:182-193
14. Hobbs C, Thoresen M, Tucker A, et al: Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia. Stroke 2008; 39:1307-1313
15. Thoresen M, Hobbs CE, Wood T, et al: Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia. J Cereb Blood Flow Metab 2009; 29:707-714
16. Chakkarapani E, Dingley J, Liu X, et al: Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs. Ann Neurol 2010; 68:330-341
17. Sheng SP, Lei B, James ML, et al: Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Anesthesiology 2012; 117:1262-1275
18. Fries M, Brücken A, Çizen A, et al: Combining xenon and mild therapeutic hypothermia preserves neurological function after prolonged cardiac arrest in pigs. Crit Care Med 2012; 40:1297-1303
19. Lai CS, Hostler D, D'Cruz BJ, et al: Prevalence of troponin-T elevation during out-of-hospital cardiac arrest. Am J Cardiol 2004; 93:754-756
20. Langhelle A, Nolan J, Herlitz J, et al: Recommended guidelines for reviewing, reporting, and conducting research on post-resuscitation care: the Utstein style. Resuscitation 2005; 66:271-283
21. Bellomo R, Ronco C, Kellum JA, et al: Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004; 8:R204-R212
22. Chua HR, Glassford N, Bellomo R: Acute kidney injury after cardiac arrest. Resuscitation 2012; 83:721-727
23. Thygesen K, Alpert JS, Jaffe AS, et al: Third universal definition of myocardial infarction. J Am Coll Cardiol 2012; 60:1581-1598
24. Brophy GM, Bell R, Claassen J, et al: Guidelines for the evaluation and management of status epilepticus. Neurocrit Care 2012; 17:3-23
25. Bedi A, Murray JM, Dingley J, et al: Use of xenon as a sedative for patients receiving critical care. Crit Care Med 2003; 31:2470-2477
26. Rossetti AO, Oddo M, Liaudet L, et al: Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermia. Neurology 2009; 72:744-749
27. Rundgren M, Westhall E, Cronberg T, et al: Continuous amplitudeintegrated electroencephalogram predicts outcome in hypothermiatreated cardiac arrest patients. Crit Care Med 2010; 38:1838-1844
28. Nakata Y, Goto T, Ishiguro Y, et al: Minimum alveolar concentration (MAC) of xenon with sevoflurane in humans. Anesthesiology 2001; 94:611-614
29. Lockwood GG, Franks NP, Downie NA, et al: Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study. Anesthesiology 2006; 104:458-465
30. Baumert JH, Hein M, Hecker KE, et al: Xenon or propofol anaesthesia for patients at cardiovascular risk in non-cardiac surgery. Br J Anaesth 2008; 100:605-611
31. Wappler F, Rossaint R, Baumert J, et al: Multicenter randomized comparison of xenon and isoflurane on left ventricular function in patients undergoing elective surgery. Anesthesiology 2007; 106:463-471
32. Custodis F, Schirmer SH, Baumhäkel M, et al: Vascular pathophysiology in response to increased heart rate. J Am Coll Cardiol 2010; 56:1973-1983
33. Bassand J-P, Hamm CW, Ardissino D, et al: Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. The Task Force for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of the European Society of Cardiology. Euro Heart J 2007; 28:1598-1660.
34. Storm C, Hasper D, Nee J, et al: Severe QTc prolongation under mild hypothermia treatment and incidence of arrhythmias after cardiac arrest-a prospective study in 34 survivors with continuous Holter ECG. Resuscitation 2011; 82:859-862
35. Stowe DF, Rehmert GC, Kwok WM, et al: Xenon does not alter cardiac function or major cation currents in isolated guinea pig hearts or myocytes. Anesthesiology 2000; 92:516-522
36. Rueckoldt H, Vangerow B, Marx G, et al: Xenon inhalation increases airway pressure in ventilated patients. Acta Anaesthesiol Scand 1999; 43:1060-1064