Extracorporeal versus conventional cardiopulmonary resuscitation after ventricular fibrillation cardiac arrest in rats: A feasibility trial

Critical Care Medicine

Volumn 41, Issue 9, 2013, Pages

  Janata, Andreas ^a,b   Magnet, Ingrid A M ^a   Drabek, Tomas ^a,b   Stezoski, Jason P ^a,b   Janesko Feldman, Keri ^a   Popp, Erik ^c   Garman, Robert H ^d   Tisherman, Samuel A ^a,b   Kochanek, Patrick M ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d Veterinary Pathology Inc   (United States)

Author keywords

CA1 hippocampus; cardiopulmonary bypass; extracorporeal membrane oxygenation; microglia; neuronal death; neuropathology; neuroprotection

Indexed keywords

ADRENALIN; BICARBONATE; HEPARIN; MORPHINE; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CARDIOPULMONARY BYPASS CANNULA; CONTROLLED STUDY; COOLING; DEFIBRILLATION; FEASIBILITY STUDY; HEART ARREST; HEART VENTRICLE FIBRILLATION; HIPPOCAMPAL CA1 REGION; IMMUNOHISTOCHEMISTRY; INDUCED HYPOTHERMIA; INTRAVENOUS CATHETER; INTUBATION; MALE; NERVE CELL; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; SUBICULUM; SURVIVAL; THALAMUS;

ANIMALS; BRAIN INJURIES; CARDIOPULMONARY RESUSCITATION; EXTRACORPOREAL MEMBRANE OXYGENATION; FEASIBILITY STUDIES; HEART ARREST; MALE; PROSPECTIVE STUDIES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME; VENTRICULAR FIBRILLATION;

EID: 84883655579     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318287f51e     Document Type: Article

References (44)

1. von Frey M, Gruber M: Untersuchungen ueber den Stoffwechsel isolirter Organe. I. Ein Respirationsapparat fuer isolirte Organe. Archiv fuer Physiologie 1885; 6:519-532
2. Gibbon JH Jr: Application of a mechanical heart and lung apparatus to cardiac surgery. Minn Med 1954; 37:171-185
3. Safar P, Abramson NS, Angelos M, et al: Emergency cardiopulmonary bypass for resuscitation from prolonged cardiac arrest. Am J Emerg Med 1990; 8:55-67
4. Hartz R, LoCicero J III, Sanders JH Jr, et al: Clinical experience with portable cardiopulmonary bypass in cardiac arrest patients. Ann Thorac Surg 1990; 50:437-441
5. Schwarz B, Mair P, Margreiter J, et al: Experience with percutaneous venoarterial cardiopulmonary bypass for emergency circulatory support. Crit Care Med 2003; 31:758-764
6. Nichol G, Karmy-Jones R, Salerno C, et al: Systematic review of percutaneous cardiopulmonary bypass for cardiac arrest or cardiogenic shock states. Resuscitation 2006; 70:381-394
7. del Nido PJ, Dalton HJ, Thompson AE, et al: Extracorporeal membrane oxygenator rescue in children during cardiac arrest after cardiac surgery. Circulation 1992; 86(5 Suppl):II300-II304
8. Topjian AA, Berg RA, Nadkarni VM: Pediatric cardiopulmonary resuscitation: Advances in science, techniques, and outcomes. Pediatrics 2008; 122:1086-1098
9. Raymond TT, Cunnyngham CB, Thompson MT, et al: Outcomes among neonates, infants, and children after extracorporeal cardiopulmonary resuscitation for refractory in-hospital pediatric cardiac arrest: A report from the National Registry of Cardiopulmonary Resuscitation. Pediatr Crit Care Med 2010; 11:362-371
10. Nagao K, Kikushima K, Watanabe K, et al: Early induction of hypothermia during cardiac arrest improves neurological outcomes in patients with out-of-hospital cardiac arrest who undergo emergency cardiopulmonary bypass and percutaneous coronary intervention. Circ J 2010; 74:77-85
11. Athanasuleas CL, Buckberg GD, Allen BS, et al: Sudden cardiac death: Directing the scope of resuscitation towards the heart and brain. Resuscitation 2006; 70:44-51
12. Rea TD, Cook AJ, Stiell IG, et al; Resuscitation Outcomes Consortium Investigators: Predicting survival after out-of-hospital cardiac arrest: Role of the Utstein data elements. Ann Emerg Med 2010; 55:249-257
13. Hossmann KA: Cerebral ischemia: Models, methods and outcomes. Neuropharmacology 2008; 55:257-270
14. Vaagenes P, Safar P, Moossy J, et al: Asphyxiation versus ventricular fibrillation cardiac arrest in dogs. Differences in cerebral resuscitation effects-A preliminary study. Resuscitation 1997; 35:41-52
15. Colbourne F, Li H, Buchan AM: Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats. J Cereb Blood Flow Metab 1999; 19:742-749
16. Lawrence EJ, Dentcheva E, Curtis KM, et al: Neuroprotection with delayed initiation of prolonged hypothermia after in vitro transient global brain ischemia. Resuscitation 2005; 64:383-388
17. Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346:549-556
18. Xu L, Emery JF, Ouyang YB, et al: Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia 2010; 58:1042-1049
19. Della-Morte D, Dave KR, DeFazio RA, et al: Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience 2009; 159:993-1002
20. Tang M, Alexander H, Clark RS, et al: Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest. J Cereb Blood Flow Metab 2010; 30:119-129
21. Fukuda S, Warner DS: Cerebral protection. Br J Anaesth 2007; 99:10-17
22. Lee SK, Vaagenes P, Safar P, et al: Effect of cardiac arrest time on cortical cerebral blood flow during subsequent standard external cardiopulmonary resuscitation in rabbits. Resuscitation 1989; 17:105-117
23. Böttiger BW, Krumnikl JJ, Gass P, et al: The cerebral 'no-reflow' phenomenon after cardiac arrest in rats-Influence of low-flow reperfusion. Resuscitation 1997; 34:79-87
24. Popp E, Rabsahl T, Schneider A, et al: Intracerebroventricular application of granulocyte colony-stimulating factor after cardiac arrest does not promote beneficial effects on cerebral recovery after cardiac arrest in rats. Resuscitation 2009; 80:478-483
25. Drabek T, Stezoski J, Garman RH, et al: Emergency preservation and delayed resuscitation allows normal recovery after exsanguination cardiac arrest in rats: A feasibility trial. Crit Care Med 2007; 35:532-537
26. Schmued LC, Stowers CC, Scallet AC, et al: Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons. Brain Res 2005; 1035:24-31
27. Pierri M, Vaudano E, Sager T, et al: KW-6002 protects from MPTP induced dopaminergic toxicity in the mouse. Neuropharmacology 2005; 48:517-524
28. Drabek T, Janata A, Jackson EK, et al: Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats. Resuscitation 2012; 83:517-526
29. Kilgannon JH, Jones AE, Shapiro NI, et al; Emergency Medicine Shock Research Network (EMShockNet) Investigators: Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010; 303:2165-2171
30. Neumar RW, Bircher NG, Sim KM, et al: Epinephrine and sodium bicarbonate during CPR following asphyxial cardiac arrest in rats. Resuscitation 1995; 29:249-263
31. Sun S, Tang W, Song F, et al: The effects of epinephrine on outcomes of normothermic and therapeutic hypothermic cardiopulmonary resuscitation. Crit Care Med 2010; 38:2175-2180
32. McCaul CL, McNamara PJ, Engelberts D, et al: Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat model. Anesth Analg 2006; 102:542-548
33. Fink EL, Alexander H, Marco CD, et al: Experimental model of pediatric asphyxial cardiopulmonary arrest in rats. Pediatr Crit Care Med 2004; 5:139-144
34. Kirino T: Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 1982; 239:57-69
35. Clark DL, Penner M, Wowk S, et al: Treatments (12 and 48 h) with systemic and brain-selective hypothermia techniques after permanent focal cerebral ischemia in rat. Exp Neurol 2009; 220:391-399
36. Katz L, Ebmeyer U, Safar P, et al: Outcome model of asphyxial cardiac arrest in rats. J Cereb Blood Flow Metab 1995; 15:1032-1039
37. Teschendorf P, Padosch SA, Spöhr F, et al: Time course of caspase activation in selectively vulnerable brain areas following global cerebral ischemia due to cardiac arrest in rats. Neurosci Lett 2008; 448:194-199
38. Yasuda Y, Shimoda T, Uno K, et al: Temporal and sequential changes of glial cells and cytokine expression during neuronal degeneration after transient global ischemia in rats. J Neuroinflammation 2011; 8:70
39. Faustino JV, Wang X, Johnson CE, et al: Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. J Neurosci 2011; 31:12992-13001
40. Han F, Boller M, Guo W, et al: A rodent model of emergency cardiopulmonary bypass resuscitation with different temperatures after asphyxial cardiac arrest. Resuscitation 2010; 81:93-99
41. Martin GB, Nowak RM, Carden DL, et al: Cardiopulmonary bypass vs CPR as treatment for prolonged canine cardiopulmonary arrest. Ann Emerg Med 1987; 16:628-636
42. Janata A, Weihs W, Schratter A, et al: Cold aortic flush and chest compressions enable good neurologic outcome after 15 mins of ventricular fibrillation in cardiac arrest in pigs. Crit Care Med 2010; 38:1637-1643
43. Tanimoto H, Ichinose K, Okamoto T, et al: Rapidly induced hypothermia with extracorporeal lung and heart assist (ECLHA) improves the neurological outcome after prolonged cardiac arrest in dogs. Resuscitation 2007; 72:128-136
44. Holzer M, Behringer W, Janata A, et al: Extracorporeal venovenous cooling for induction of mild hypothermia in human-sized swine. Crit Care Med 2005; 33:1346-1350