Expression of Rac-1 related to tumor depth, lymph node metastasis and patient prognosis in esophageal squamous cell carcinoma

Medical Oncology

Volumn 30, Issue 4, 2013, Pages

  Yang, Qing ^a   Luo, Guang Yu ^a   Li, Yin ^a   Shan, Hong Bo ^a   Wang, Hui Yun ^a   Xu, Guo Liang ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Esophageal squamous cell carcinoma (ESCC); Immunohistochemistry; Lymph node metastasis; Prognosis; Rac 1

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; MOLECULAR MARKER; RAC1 PROTEIN; RAC1 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CANCER GROWTH; CANCER LOCALIZATION; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CONTROLLED STUDY; CYTOPLASM; DISEASE FREE SURVIVAL; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR INVASION; UPREGULATION; WESTERN BLOTTING; BIOSYNTHESIS; EPITHELIUM CELL; ESOPHAGUS TUMOR; GENETICS; LYMPH NODE; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; DISEASE-FREE SURVIVAL; EPITHELIAL CELLS; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROGNOSIS; RAC1 GTP-BINDING PROTEIN; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84883626556     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-013-0689-2     Document Type: Article

References (28)

1. Shibata A, Matsuda T, Ajiki W, et al. Trend in incidence of adenocarcinoma of the esophagus in Japan, 1993-2001. Jpn J Clin Oncol. 2008;38(7):464-8.
2. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58(2):71-96. (Pubitemid 351521864)
3. Chin L, Tam A, Pomerantz J, et al. Essential role for oncogenic Ras in tumour maintenance. Nature. 1999;400(6743):468-72. (Pubitemid 29361802)
4. Irani K, Xia Y, Zweier JL, et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science. 1997;275(5306):1649-52. (Pubitemid 27120541)
5. Sun DD, Xu B, Zhang D. Rac signaling in tumorigenesis and as target for anticancer drug development. Drug Resist Updat. 2006;9(6):274-87. (Pubitemid 46357635)
6. Kaibuchi K, Kuroda S, Amano M. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem. 1999;68:459-86. (Pubitemid 29449200)
7. Condeelis JS, Wyckoff JB, Bailly M, et al. Lamellipodia in invasion. Semin Cancer Biol. 2001;11(2):119-28. (Pubitemid 32423287)
8. Hahn A, Barth H, Kress M, et al. Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression. Biochem J. 2002;362(Pt 1):33-40. (Pubitemid 34174459)
9. Wu MF, Xi L, Chen G, Ling J, Xu Q, et al. Expression and significance of T lymphoma invasion/metastasis gene in ovarian cancer cells. Acta Acad Med Sinica. 2003;4:434-7.
10. Tan W, Palmby TR, Gavard J, Amornphimoltham P, Zheng Y, Gutkind JS. An essential role for Rac1 in endothelial cell function and vascular development. FASEB J. 2008;22(6):1829-38. (Pubitemid 351811460)
11. Garrett TA, Van Buul JD, Burridge K. VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2. Exp Cell Res. 2007;313(15):3285-97. (Pubitemid 47284065)
12. Ma YH, Shi L, Su Q. LIM kinase and tumor. J Int Pathol Clin Med. 2009;6:490-4.
13. Bagheri-Yarmand R, Mazumdar A, Sahin AA, Kumar R. LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system. Int J Cancer. 2006;118(11):2703-10. (Pubitemid 43673347)
14. Hordijk PL, Ten Klooster JP, van der Kammen RA, Michiels F, Oomen LC, Collard JG. Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science. 1997;278(5342):1464-6. (Pubitemid 27509819)
15. Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF. Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells. Breast Cancer Res. 2005;7(6):R965-74.
16. Sierra A. Metastases and their microenvironments: linking pathogenesis and therapy. Drug Resist Updat. 2005;8(4):247-57. (Pubitemid 41446966)
17. Chan AY, Coniglio SJ, Chuang YY, Michaelson D, et al. Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. Oncogen. 2005;24(53):7821-9. (Pubitemid 41715188)
18. Lozano E, Betson M, Braga VM. Tumor progression: small GTPases and loss of cell-cell adhesion. BioEssays. 2003;25(5):452-63. (Pubitemid 36565683)
19. Malliri A, Collard JG. Role of Rho-family proteins in cell adhesion and cancer. Curr Opin Cell Biol. 2003;15(5):583-9. (Pubitemid 37176967)
20. Schmitz AA, Govek EE, Bottner B, Van Aelst L. Rho GTPases: signaling, migration, and invasion. Exp Cell Res. 2000;261(1):1-12.
21. Quilliam LA, Khosravi-Far R, Huff SY, Der CJ. Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. Bioessays. 1995;17(5):395-404.
22. Nakada M, Drake KL, Nakada S, Niska JA, Berens ME. Ephrin-B3 ligand promotes glioma invasion through activation of Rac1. Cancer Res. 2006;66(17):8492-500. (Pubitemid 44449162)
23. Tran NL, McDonough WS, Savitch BA, Fortin SP, Winkles JA, et al. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. Cancer Res. 2006;66(19):9535-42. (Pubitemid 44623652)
24. Liu MF, Shi RH, Zhang GX, Hao B, Zhu H, Zhou XQ. Expression and effect of cell proliferation of Rac1, HIF-1α in human esophageal squamous cancer cell line Eca-109. Acta Universitatis Medicinalis Nanjing. 2009; 29(5): 652-5, 710.
25. Yang W, Lv S, Liu X, Liu H, Yang W, Hu F. Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma. Jpn J Clin Oncol. 2010;40(11):1053-9.
26. Qi Y, Huang B, Yu LL, Wang Q, Lan GP, Zhang QH. Prognostic value of Tiam1 and Rac1 overexpression in nasopharyngeal carcinoma. ORL J Otorhinolaryngol Relat Spec. 2009;71(3):163-71.
27. Mendoza-Catalan MA, Cristobal-Mondragon GR, Adame-Gomez J, Del Valle-Flores HN, et al. Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells. BMC Cancer. 2012;. doi: 10.1186/1471-2407-12- 116.
28. Su L, Xu W, Yan GZ, Luo W, Wang YL, Chen S, et al. Biological significance of relationship between nuclear localization of Rac1 and progression of gastric carcinoma. Zhonghua Zhong Liu Za Zhi. 2011; 33(9): 676-80.