High Cost and Low Survival Rate in High Comorbidity Incident Elderly Hemodialysis Patients

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Lin, Yi Ting ^a,b   Wu, Ping Hsun ^a,b   Kuo, Mei Chuan ^a,b   Lin, Ming Yen ^a   Lee, Tzu Chi ^b   Chiu, Yi Wen ^a,b   Hwang, Shang Jyh ^a,b   Chen, Hung Chun ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AGE DISTRIBUTION; AGED; ARTICLE; CHARLSON COMORBIDITY INDEX; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; DISEASE REGISTRY; FEMALE; FOLLOW UP; GERIATRIC PATIENT; HEALTH CARE COST; HEALTH INSURANCE; HEALTH SERVICE; HEMODIALYSIS PATIENT; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; ICD-9-CM; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTPATIENT; POPULATION RESEARCH; SURVIVAL RATE; SURVIVAL TIME; TAIWAN; TERMINAL DISEASE; TREATMENT DURATION; AGE; AMBULATORY CARE; ECONOMICS; RENAL REPLACEMENT THERAPY; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; AMBULATORY CARE; COMORBIDITY; FEMALE; HOSPITALIZATION; HUMANS; MALE; RENAL DIALYSIS; SURVIVAL RATE;

EID: 84883617397     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075318     Document Type: Article

References (41)

1. Mignon F, Michel C, Mentre F, Viron B, (1993) Worldwide demographics and future trends of the management of renal failure in the elderly. Kidney Int Suppl 41: S18-S26. PubMed: 8320916.
2. Feest TG, Mistry CD, Grimes DS, Mallick NP, (1990) Incidence of advanced chronic renal failure and the need for end stage renal replacement treatment. BMJ 301: 897-900. doi:10.1136/bmj.301.6757.897. PubMed: 2261533.
3. Kurella Tamura M, (2009) Incidence, management, and outcomes of end-stage renal disease in the elderly. Curr Opin Nephrol Hypertens 18: 252-257. doi:10.1097/MNH.0b013e328326f3ac. PubMed: 19374012.
4. Jager KJ, van Dijk PC, Dekker FW, Stengel B, Simpson K, et al. (2003) The epidemic of aging in renal replacement therapy: an update on elderly patients and their outcomes. Clin Nephrol 60: 352-360. PubMed: 14640241.
5. Pascual J, Orofino L, Liaño F, Marcén R, Naya MT, et al. (1990) Incidence and prognosis of acute renal failure in older patients. J Am Geriatr Soc 38: 25-30. PubMed: 2295766.
6. Hsu CY, McCulloch CE, Fan D, Ordoñez JD, Chertow GM, et al. (2007) Community-based incidence of acute renal failure. Kidney Int 72: 208-212. doi:10.1038/sj.ki.5002297. PubMed: 17507907.
7. Waikar SS, Curhan GC, Wald R, McCarthy EP, Chertow GM, (2006) Declining mortality in patients with acute renal failure, 1988 to 2002. J Am Soc Nephrol 17: 1143-1150. doi:10.1681/ASN.2005091017. PubMed: 16495376.
8. Yang WC, Hwang SJ, (2008) Incidence, prevalence and mortality trends of dialysis end-stage renal disease in Taiwan from 1990 to 2001: the impact of national health insurance. Nephrol Dial Transplant 23: 3977-3982. doi:10.1093/ndt/gfn406. PubMed: 18628366.
9. Health Do (1994) Department of Health, Executive Yuan, R.O.C., Taiwan. Health and Vital Statistic: (2) Vital Statistics.
10. Joly D, Anglicheau D, Alberti C, Nguyen AT, Touam M, et al. (2003) Octogenarians reaching end-stage renal disease: cohort study of decision-making and clinical outcomes. J Am Soc Nephrol 14: 1012-1021. doi:10.1097/01.ASN.0000054493.04151.80. PubMed: 12660336.
11. Smith C, Da Silva-Gane M, Chandna S, Warwicker P, Greenwood R, et al. (2003) Choosing not to dialyse: evaluation of planned non-dialytic management in a cohort of patients with end-stage renal failure. Nephron Clin Pract 95: c40-c46. doi:10.1159/000073708. PubMed: 14610329.
12. Winkelmayer WC, Weinstein MC, Mittleman MA, Glynn RJ, Pliskin JS, (2002) Health economic evaluations: the special case of end-stage renal disease treatment. Med Decis Mak 22: 417-430. doi:10.1177/027298902236927. PubMed: 12365484.
13. Lima-Costa MF, Veras R, (2003) Aging and public health. Cad Saude Publica 19: 700,.
14. Charlson ME, Pompei P, Ales KL, MacKenzie CR, (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40: 373-383. doi:10.1016/0021-9681(87)90171-8. PubMed: 3558716.
15. Athienites NV, Miskulin DC, Fernandez G, Bunnapradist S, Simon G, et al. (2000) Comorbidity assessment in hemodialysis and peritoneal dialysis using the index of coexistent disease. Semin Dial 13: 320-326. PubMed: 11014695.
16. Davies SJ, Russell L, Bryan J, Phillips L, Russell GI, (1995) Comorbidity, urea kinetics, and appetite in continuous ambulatory peritoneal dialysis patients: their interrelationship and prediction of survival. Am J Kidney Dis 26: 353-361. doi:10.1016/0272-6386(95)90657-6. PubMed: 7645541.
17. Khan IH, Catto GR, Edward N, Fleming LW, Henderson IS, et al. (1993) Influence of coexisting disease on survival on renal-replacement therapy. Lancet 341: 415-418. doi:10.1016/0140-6736(93)93003-J. PubMed: 8094182.
18. van Manen JG, Korevaar JC, Dekker FW, Boeschoten EW, Bossuyt PM, et al. (2002) How to adjust for comorbidity in survival studies in ESRD patients: a comparison of different indices. Am J Kidney Dis 40: 82-89. doi:10.1053/ajkd.2002.33916. PubMed: 12087565.
19. Hall SF, (2006) A user's guide to selecting a comorbidity index for clinical research. J Clin Epidemiol 59: 849-855. doi:10.1016/j.jclinepi.2005.11.013. PubMed: 16828679.
20. Icks A, Haastert B, Gandjour A, Chernyak N, Rathmann W, et al. (2010) Costs of dialysis--a regional population-based analysis. Nephrol Dial Transplant 25: 1647-1652. doi:10.1093/ndt/gfp672. PubMed: 20008830.
21. Wu PH, Lin YT, Lee TC, Lin MY, Kuo MC, et al. (2013) Predicting mortality of incident dialysis patients in taiwan- a longitudinal population-based study. PLOS ONE 8: e61930. doi:10.1371/journal.pone.0061930. PubMed: 23626754.
22. Deyo RA, Cherkin DC, Ciol MA, (1992) Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 45: 613-619. doi:10.1016/0895-4356(92)90133-8. PubMed: 1607900.
23. Cheng TM, (2003) Taiwan's new national health insurance program: genesis and experience so far. Health Aff Millwood 22: 61-76. doi:10.1377/hlthaff.22.3.61. PubMed: 12757273.
24. Chandna SM, Schulz J, Lawrence C, Greenwood RN, Farrington K, (1999) Is there a rationale for rationing chronic dialysis? A hospital based cohort study of factors affecting survival and morbidity. BMJ 318: 217-223. doi:10.1136/bmj.318.7178.217. PubMed: 9915728.
25. Munshi SK, Vijayakumar N, Taub NA, Bhullar H, Lo TC, et al. (2001) Outcome of renal replacement therapy in the very elderly. Nephrol Dial Transplant 16: 128-133. doi:10.1093/ndt/16.1.128. PubMed: 11209006.
26. Lamping DL, Constantinovici N, Roderick P, Normand C, Henderson L, et al. (2000) Clinical outcomes, quality of life, and costs in the North Thames Dialysis Study of elderly people on dialysis: a prospective cohort study. Lancet 356: 1543-1550. doi:10.1016/S0140-6736(00)03123-8. PubMed: 11075766.
27. Jassal SV, Trpeski L, Zhu N, Fenton S, Hemmelgarn B, (2007) Changes in survival among elderly patients initiating dialysis from 1990 to 1999. CMAJ 177: 1033-1038. PubMed: 17954892.
28. Kurella M, Covinsky KE, Collins AJ, Chertow GM, (2007) Octogenarians and nonagenarians starting dialysis in the United States. Ann Intern Med 146: 177-183. doi:10.7326/0003-4819-146-3-200702060-00006. PubMed: 17283348.
29. Piatnochka IT, Bel'skaia OV, Karpiuk RM, Petrushevskaia LKh, (1989) [Risk of lung cancer in patients followed-up at tuberculosis dispensaries]. Probl Tuberk: pp. 21-23. PubMed: 2813306.
30. Murtagh FE, Marsh JE, Donohoe P, Ekbal NJ, Sheerin NS, et al. (2007) Dialysis or not? A comparative survival study of patients over 75 years with chronic kidney disease stage 5. Nephrol Dial Transplant 22: 1955-1962. doi:10.1093/ndt/gfm153. PubMed: 17412702.
31. Jassal SV, Watson D, (2009) Dialysis in late life: benefit or burden. Clin J Am Soc Nephrol 4: 2008-2012. doi:10.2215/CJN.04610709. PubMed: 19965545.
32. Moss AH, Holley JL, Upton MB, (1992) Outcomes of cardiopulmonary resuscitation in dialysis patients. J Am Soc Nephrol 3: 1238-1243. PubMed: 1477319.
33. Burns A, (2003) Conservative management of end-stage renal failure: masterly inactivity or benign neglect? See Smith et al., pp. c40-c46. Nephron Clin Pract 95: c37-39.
34. Davison SN, (2012) The ethics of end-of-life care for patients with ESRD. Clin J Am Soc Nephrol 7: 2049-2057. doi:10.2215/CJN.03900412. PubMed: 22997341.
35. Carson RC, Juszczak M, Davenport A, Burns A, (2009) Is maximum conservative management an equivalent treatment option to dialysis for elderly patients with significant comorbid disease? Clin J Am Soc Nephrol 4: 1611-1619. doi:10.2215/CJN.00510109. PubMed: 19808244.
36. Carson R, (2012) Deny dialysis or "D-NI" dialysis? The case for "do not initiate; do not ignore" orders. Clin J Am Soc Nephrol 7: 1924-1926. doi:10.2215/CJN.11171012. PubMed: 23221096.
37. Schmidt RJ, (2012) Informing our elders about dialysis: is an age-attuned approach warranted? Clin J Am Soc Nephrol 7: 185-191. doi:10.2215/CJN.10401011. PubMed: 22173860.
38. Grun RP, Constantinovici N, Normand C, Lamping DL, (2003) Costs of dialysis for elderly people in the UK. Nephrol Dial Transplant 18: 2122-2127. doi:10.1093/ndt/gfg354. PubMed: 13679490.
39. Teerawattananon Y, Mugford M, Tangcharoensathien V, (2007) Economic evaluation of palliative management versus peritoneal dialysis and hemodialysis for end-stage renal disease: evidence for coverage decisions in Thailand. Value Health 10: 61-72. doi:10.1111/j.1524-4733.2006.00145.x. PubMed: 17261117.
40. Thorsteinsdottir B, Swetz KM, Tilburt JC, (2013) Dialysis in the Frail Elderly- A Current Ethical Problem, an Impending Ethical Crisis. J Gen Intern Med. PubMed: 23686511.
41. Fried L, Bernardini J, Piraino B, (2001) Charlson comorbidity index as a predictor of outcomes in incident peritoneal dialysis patients. Am J Kidney Dis 37: 337-342. doi:10.1053/ajkd.2001.21300. PubMed: 11157375.