An association study between the norepinephrine transporter gene and depression

Psychiatric Genetics

Volumn 23, Issue 5, 2013, Pages 217-221

  Buttenschøn, Henriette N ^b   Jacobsen, Iben S ^b   Grynderup, Matias B ^a   Hansen, Åse M ^c,d   Kolstad, Henrik A ^a   Kaerlev, Linda ^a,g   Thomsen, Jane F ^c   Nordentoft, Merete ^b,e   Silahtaroglu, Asli ^f   Tommerup, Niels ^f   Tümer, Zeynep ^f,h   Krogh, Jesper ^e   Børglum, Anders D ^a,b   Mors, Ole ^a,b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c BISPEBJERG HOSPITAL   (Denmark)

^d Department of Public Health   (Denmark)

^e Psychiatric Center Copenhagen   (Denmark)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g ODENSE UNIVERSITY HOSPITAL   (Denmark)

^h JOHN F KENNEDY INSTITUTE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

NORADRENALIN TRANSPORTER;

ADULT; ARTICLE; CONTROLLED STUDY; DENMARK; DEPRESSION; DISEASE ASSOCIATION; FEMALE; GENE TRANSLOCATION; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUALITY CONTROL; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL;

ADULT; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 16; DEPRESSION; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HUMANS; MALE; MIDDLE AGED; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; TRANSLOCATION, GENETIC;

EID: 84883617374     PISSN: 09558829     EISSN: 14735873     Source Type: Journal    
DOI: 10.1097/YPG.0000000000000003     Document Type: Article

References (35)

1. Alonso J, Angermeyer MC, Bernert S, Bruffaerts R., Brugha TS, Bryson H, et al (2004). Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand Suppl 109:21-27.
2. Aragam N, Wang KS, Pan Y. (2011). Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. J Affect Disord 133:516-521.
3. Bech P, Rasmussen NA, Olsen L.R., Noerholm V., Abildgaard W. (2001). The sensitivity and specificity of the Major Depression Inventory, using the Present State Examination as the index of diagnostic validity. J Affect Disord 66: 159-164. (Pubitemid 32907521)
4. Bosker FJ, Hartman CA, Nolte I.M., Prins BP, Terpstra P, Posthuma D, et al (2010). Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol Psychiatry 16:516-532.
5. Breen G, Webb BT, Butler A.W., van den Oord EJ, Tozzi F, Craddock N, et al. (2011). A genome-wide significant linkage for severe depression on chromosome 3: the depression network study. Am J Psychiatry 168: 840-847.
6. Buttenschøn HN, Kristensen AS, Buch HN, Andersen JH, Bonde JP, Grynderup M, et al. (2011). The norepinephrine transporter gene is a candidate gene for panic disorder. J Neural Transm 118:969-976.
7. Chang CC, Lu RB, Chen C.L., Chu CM, Chang HA, Huang CC, et al (2007). Lack of association between the norepinephrine transporter gene and major depression in a Han Chinese population. J Psychiatry Neurosci 32:121-128.
8. Curtis D, Vine AE, Knight J. (2008). A simple method for assessing the strength of evidence for association at the level of the whole gene. Adv Appl Bioinform Chem 1:115-120.
9. Dell'Osso B, Palazzo MC, Oldani L, Altamura AC (2011). The noradrenergic action in antidepressant treatments: pharmacological and clinical aspects. CNS Neurosci Ther 17:723-732.
10. Farmer A, Breen G, Brewster S., Craddock N, Gill M, Korszun A., et al. (2004). The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study. BMC Psychiatry 4:42.
11. Inoue K, Itoh K, Yoshida K., Shimizu T, Suzuki T. (2004). Positive association between T-182C polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population. Neuropsychobiology 50:301-304. (Pubitemid 39482669)
12. Kaerlev L, Kolstad HA, Hansen A.M., Thomsen JF, Kaergaard A, Rugulies R, et al (2011). Are risk estimates biased in follow-up studies of psychosocial factors with low base-line participation? BMC Public Health 11:539.
13. Kolstad HA, Hansen AM, Kaergaard A, Thomsen J.F., Kaerlev L., Mikkelsen S, et al (2011). Job strain and the risk of depression: is reporting biased? Am J Epidemiol 173:94-102.
14. Krogh J, Petersen L, Timmermann M., Saltin B, Nordentoft M. (2007). Design paper: the DEMO trial: a randomized, parallel-group, observer-blinded clinical trial of aerobic versus non-aerobic versus relaxation training for patients with light to moderate depression. Contemp Clin Trials 28:79-89. (Pubitemid 44780207)
15. Lewis CM, Ng MY, Butler A.W., Cohen-Woods S, Uher R, Pirlo K., et al. (2010). Genome-wide association study of major recurrent depression in the U.K. population. Am J Psychiatry 167:949-957.
16. Li Y, Abecasis G.R. (2006). Rapid haplotype reconstruction and missing genotype inference. Am J Hum Genet S79:2290.
17. Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium (2013). A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry 18:497-511.
18. Millar JK, Wilson-Annan JC, Anderson S., Christie S, Taylor MS, Semple C.A., et al. (2000). Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 9:1415-1423. (Pubitemid 30312490)
19. Muglia P, Tozzi F, Galwey N.W., Francks C., Upmanyu R, Kong XQ, et al (2010). Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Mol Psychiatry 15:589-601.
20. Purcell S, Neale B, Todd-Brown K, Thomas L., Ferreira MA, Bender D, et al (2007). PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559-575. (Pubitemid 47330214)
21. Ryu SH, Lee SH, Lee H.J., Cha JH, Ham BJ, Han CS, et al (2004). Association between norepinephrine transporter gene polymorphism and major depression. Neuropsychobiology 49:174-177.
22. Shi J, Potash JB, Knowles J.A., Weissman MM, Coryell W, Scheftner WA, et al (2011). Genome-wide association study of recurrent early-onset major depressive disorder. Mol Psychiatry 16:193-201.
23. Shyn SI, Shi J, Kraft J.B., Potash JB, Knowles JA, Weissman MM, et al (2011). Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Mol Psychiatry 16:202-215.
24. St Clair D., Blackwood D, Muir W., Carothers A, Walker M, Spowart G., et al. (1990). Association within a family of a balanced autosomal translocation with major mental illness. Lancet 336:13-16. (Pubitemid 20207869)
25. Sullivan PF, Neale MC, Kendler K.S. (2000). Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 157:1552-1562.
26. Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit J.H., Zandbelt T., et al. (2009). Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 14:359-375.
27. Taipale M, Kaminen N, Nopola-Hemmi J, Haltia T., Myllyluoma B, Lyytinen H, et al (2003). A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. Proc Natl Acad Sci USA 100:11553-11558. (Pubitemid 37205974)
28. Tommerup N (1993). Mendelian cytogenetics. Chromosome rearrangements associated with mendelian disorders. J Med Genet 30:713-727.
29. Torres GE, Gainetdinov RR, Caron M.G. (2003). Plasma membrane mono-amine transporters: structure, regulation and function. Nat Rev Neurosci 4: 13-25. (Pubitemid 37271085)
30. Uher R, Huezo-Diaz P, Perroud N., Smith R, Rietschel M, Mors O., et al. (2009a). Genetic predictors of response to antidepressants in the GENDEP project. Pharmacogenomics J 9:225-233.
31. Uher R, Maier W, Hauser J., Marusic A, Schmael C, Mors O., et al. (2009b). Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression. Br J Psychiatry 194:252-259.
32. Uher R, Perroud N, Ng M.Y., Hauser J., Henigsberg N, Maier W, et al (2010). Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. Am J Psychiatry 167:555-564.
33. World Health Organization (1998). Diagnosis and clinical measurement in psychiatry. A reference manual for SCAN. In: Wing JK, Sartorius N, ÜUstün TB, editors. Cambridge University Press: World Health Organization.
34. Wray NR, Pergadia ML, Blackwood D.H., Penninx BW, Gordon SD, Nyholt DR, et al (2012). Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Mol Psychiatry 17:36-48.
35. Zill P, Engel R, Baghai T.C., Juckel G., Frodl T, Muller-Siecheneder F, et al (2002). Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression. Neuropsy-chopharmacology 26:489-493. (Pubitemid 34260998)