Activation of mTOR in the spinal cord is required for pain hypersensitivity induced by chronic constriction injury in mice

Pharmacology Biochemistry and Behavior

Volumn 111, Issue , 2013, Pages 64-70

  Zhang, Wei ^a   Sun, Xiao Feng ^a   Bo, Jin Hua ^a   Zhang, Juan ^a   Liu, Xiao Jie ^a   Wu, Liu Ping ^a   Ma, Zheng Liang ^a   Gu, Xiao Ping ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

mTOR; Neuropathic pain; Rapamycin

Indexed keywords

POSTSYNAPTIC DENSITY PROTEIN 95; RAPAMYCIN;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC CONSTRICTION INJURY; CHRONIC PAIN; DRUG EFFECT; ENZYME ACTIVATION; HYPERALGESIA; IMMUNOPRECIPITATION; INJURY; LATENT PERIOD; LIGATION; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SPINAL CORD DORSAL HORN; UPREGULATION; WESTERN BLOTTING;

MAMMALIA; MUS;

MTOR; NEUROPATHIC PAIN; RAPAMYCIN;

ANIMALS; BEHAVIOR, ANIMAL; CHRONIC DISEASE; MALE; MICE; MICE, INBRED C57BL; PAIN THRESHOLD; SIROLIMUS; SPINAL CORD COMPRESSION; SPINAL CORD INJURIES; TOR SERINE-THREONINE KINASES;

EID: 84883613741     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2013.07.017     Document Type: Article

References (30)

1. G.J. Bennett, and Y.K. Xie A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man Pain 33 1988 87 107
2. M. Costigan, J. Scholz, and C.J. Woolf Neuropathic pain: a maladaptive response of the nervous system to damage Annu Rev Neurosci 32 2009 1 32
3. R. D'Mello, F. Marchand, S. Pezet, S.B. McMahon, and A.H. Dickenson Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain Mol Ther 19 2011 1780 1792
4. K. Futai, M.J. Kim, T. Hashikawa, P. Scheiffele, M. Sheng, and Y. Hayashi Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin Nat Neurosci 10 2007 186 195 (Pubitemid 46174843)
5. E.M. Garry, A. Moss, A. Delaney, F. O'Neill, J. Blakemore, and J. Bowen Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice Curr Biol 13 2003 321 328 (Pubitemid 36230023)
6. S.M. Geranton, L. Jimenez-Diaz, C. Torsney, K.K. Tochiki, S.A. Stuart, and J.L. Leith A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states J Neurosci 29 2009 15017 15027
7. N. Hay, and N. Sonenberg Upstream and downstream of mTOR Genes Dev 18 2004 1926 1945 (Pubitemid 39071573)
8. J.T. Isaac, M.C. Ashby, and C.J. McBain The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity Neuron 54 2007 859 871 (Pubitemid 46907505)
9. L. Jimenez-Diaz, S.M. Geranton, G.M. Passmore, J.L. Leith, A.S. Fisher, and L. Berliocchi Local translation in primary afferent fibers regulates nociception PLoS One 3 2008 e1961
10. L.V. Kalia, S.K. Kalia, and M.W. Salter NMDA receptors in clinical neurology: excitatory times ahead Lancet Neurol 7 2008 742 755 (Pubitemid 351957932)
11. H.W. Kessels, and R. Malinow Synaptic AMPA receptor plasticity and behavior Neuron 61 2009 340 350
12. M.J. Kim, K. Futai, J. Jo, Y. Hayashi, K. Cho, and M. Sheng Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95 Neuron 56 2007 488 502 (Pubitemid 350026266)
13. R. Kuner Central mechanisms of pathological pain Nat Med 16 2010 1258 1266
14. A. Latremoliere, and C.J. Woolf Central sensitization: a generator of pain hypersensitivity by central neural plasticity J Pain 10 2009 895 926
15. X.J. Liu, and M.W. Salter Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn Eur J Neurosci 32 2010 278 289
16. X.M. Ma, and J. Blenis Molecular mechanisms of mTOR-mediated translational control Nat Rev Mol Cell Biol 10 2009 307 318
17. T. Ma, C.A. Hoeffer, E. Capetillo-Zarate, F. Yu, H. Wong, and M.T. Lin Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease PLoS One 5 2010
18. G.E. Norsted, S. Codeluppi, J.A. Gregory, J. Steinauer, and C.I. Svensson Mammalian target of rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation Neuroscience 169 2010 1392 1402
19. I. Obara, K.K. Tochiki, S.M. Géranton, F.B. Carr, B.M. Lumb, and Q. Liu Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice Pain 152 11 Nov 2011 2582 2595
20. E. Polgar, M. Watanabe, B. Hartmann, S.G. Grant, and A.J. Todd Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn Mol Pain 4 2008 5
21. T.J. Price, and S.M. Geranton Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology Eur J Neurosci 29 2009 2253 2263
22. T.J. Price, M.H. Rashid, M. Millecamps, R. Sanoja, J.M. Entrena, and F. Cervero Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR J Neurosci 27 2007 13958 13967 (Pubitemid 351377872)
23. S.J. Tang, G. Reis, H. Kang, A.C. Gingras, N. Sonenberg, and E.M. Schuman A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus Proc Natl Acad Sci U S A 99 2002 467 472 (Pubitemid 34060384)
24. F. Tao, Y.X. Tao, J.A. Gonzalez, M. Fang, P. Mao, and R.A. Johns Knockdown of PSD-95/SAP90 delays the development of neuropathic pain in rats Neuroreport 12 2001 3251 3255 (Pubitemid 33010653)
25. F. Tao, Q. Su, and R.A. Johns Cell-permeable peptide Tat-PSD-95 PDZ2 inhibits chronic inflammatory pain behaviors in mice Mol Ther 16 2008 1776 1782
26. W.P. Wu, X.J. Xu, and J.X. Hao Chronic lumbar catheterization of the spinal subarachnoid space in mice J Neurosci Methods 133 2004 65 69
27. Q. Xu, B. Fitzsimmons, J. Steinauer, A. O'Neill, A.C. Newton, and X.Y. Hua Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia J Neurosci 31 2011 2113 2124
28. P.C. Yang, C.H. Yang, C.C. Huang, and K.S. Hsu Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity J Biol Chem 283 2008 2631 2643
29. T. Yasaka, D.I. Hughes, E. Polgar, G.G. Nagy, M. Watanabe, and J.S. Riddell Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord J Neurosci 29 2009 13401 13409
30. H.Y. Zhou, S.R. Chen, and H.L. Pan Targeting N-methyl-d-aspartate receptors for treatment of neuropathic pain Expert Rev Clin Pharmacol 4 2011 379 388