Epithelial-Mesenchymal Transition Associates with Maintenance of Stemness in Spheroid-Derived Stem-Like Colon Cancer Cells

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Han, Xiao Yan ^a   Wei, Bo ^a   Fang, Jia Feng ^a   Zhang, Shi ^a   Zhang, Fu Cheng ^a   Zhang, Hai Bo ^a   Lan, Tian Yun ^a   Lu, Hui Qiong ^a   Wei, Hong Bo ^a  

^a THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STEM CELL; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL STRAIN HCT116; CELL STRAIN HT29; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ACTINS; BETA CATENIN; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HT29 CELLS; HUMANS; NEOPLASTIC STEM CELLS; SPHEROIDS, CELLULAR; UP-REGULATION; VIMENTIN; WNT SIGNALING PATHWAY;

EID: 84883610181     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073341     Document Type: Article

References (36)

1. O'Connell JB, Maggard MA, Ko CY, (2004) Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 96: 1420-1425.
2. Berrino F, De Angelis R, Sant M, Rosso S, Bielska-Lasota M, et al. (2007) Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study. Lancet Oncol 8: 773-783.
3. Goode BL, Eck MJ, (2007) Mechanism and function of formins in the control of actin assembly. Annu Rev Biochem 76: 593-627.
4. Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, et al. (2007) Positive feedback between Dial, LARG, and RhoA regμlates cell morphology and invision. Genes Dev 21: 1478-1483.
5. Guarino M, Rubino B, Ballabio G, (2007) The role of epithelial-mesenchymal transition in cancer pathology. Pathology 39: 305-318.
6. Fang DD, Kim YJ, Lee CN, Aggarwal S, McKinnon K, et al. (2010) Expansion of CD133+ colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery. Br J Cancer 102: 1265-1275.
7. O'Brien CA, Pollett A, Gallinger S, Dick JE, (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106-110.
8. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, et al. (2004) Identification of human brain tumour initiating cells. Nature 432: 396-401.
9. Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, et al. (2007) Identification of pancreatic cancer stem cells. Cancer Res 67: 1030-1037.
10. Wei B, Han XY, Qi CL, Zhang S, Zheng ZH, et al. (2012) Coaction of Spheroid-Derived Stem-like Cells and Endothelial Progenitor Cells Promotes Development of Colon Cancer. Plos one 7: e39069.
11. Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T, (2005) Opinion: migrating cancer stem cells-an integrated concept of malignant tumour progression. Nat Rev Cancer 5: 744-749.
12. Brabletz T, Hlubek F, Spaderna S, Schmalhofer O, Hiendlmeyer E, et al. (2005) Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs 179: 56-65.
13. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715.
14. Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, et al. (2009) Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci 106: 13820-13825.
15. Blavier L, Lazaryev A, Shi XH, Dorey FJ, Shackleford GM, et al. (2010) Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther 10: 198-208.
16. Jiang YG, Luo Y, He DL, Li X, Zhang LL, et al. (2007) Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1alpha. Int J Urol 14: 1034-1039.
17. Howard S, Deroo T, Fujita Y, Itasaki N, (2011) A Positive Role of Cadherin in Wnt/β-Catenin Signalling during Epithelial-Mesenchymal Transition. PLoS One 6: e23899.
18. Fidler IJ, Kripke ML, (1977) Metastasis results from preexisting variant cells within a malignant tumor. Science 197(4306): 893-895.
19. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, et al. (2006) Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66: 9339-9344.
20. Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, et al. (2007) Identification and expansion of human colon-cancer-initiating cells. Nature 445: 111-115.
21. Umemoto T, Yamato M, Nishida K, Yang J, Tano Y, et al. (2006) Limbal epithelial side-population cells have stem cell-like properties, including quiescent state. Stem Cells 24: 86-94.
22. Haraguchi N, Utsunomiya T, Inoue H, Tanaka F, Mimori K, et al. (2006) Characterization of a side population of cancer cells from human gastrointestinal system. Stem Cells 24: 506-513.
23. Wang J, Guo LP, Chen LZ, Zeng YX, Lu SH, (2007) Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Cancer Res 67: 3716-3724.
24. Singh SK, Clarke ID, Terassaki M, Bonn VE, Hawkins C, et al. (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63: 5821-5828.
25. Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, et al. (2005) Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 65: 5506-5511.
26. Thiery JP, (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
27. Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T, (2005) Opinion: Migrating cancer stem cells- an integrated concept of malignant tumour progression. Nat Rev Cancer 5: 744-749.
28. Berx G, Raspe E, Christofori G, Thiery JP, Sleeman JP, (2007) Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer. Clin Exp Metastasis 24: 587-597.
29. Buda A, Pignatelli M, (2004) Cytoskeletal network in colon cancer: from genes to clinical application. Int J Biochem Cell Biol 36: 759-765.
30. Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, et al. (2009) Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol 7: e1000121.
31. Brabletz S, Schmalhofer O, Brabletz T, (2009) Gastrointestinal stem cells in development and cancer. J Pathol 217: 307-317.
32. Kolligs FT, Bommer G, Goke B, (2002) Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion 66: 131-144.
33. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, et al. (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275: 1787-1790.
34. Clevers H, (2006) Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480.
35. Yook JI, Li XY, Ota I, Fearon ER, Weiss SJ, (2005) Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem 280: 11740-11748.
36. Zhou WJ, Geng ZH, Chi S, Zhang W, Niu XF, et al. (2011) Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Research 21: 609-626.