Evaluation of hemostatic biomarker abnormalities that precede platelet count decline in critically ill patients with sepsis

Journal of Critical Care

Volumn 28, Issue 5, 2013, Pages 556-563

  Koyama, Kansuke ^a   Madoiwa, Seiji ^a   Tanaka, Shinichiro ^a   Koinuma, Toshitaka ^a   Wada, Masahiko ^a   Sakata, Asuka ^a   Ohmori, Tsukasa ^a   Mimuro, Jun ^a   Nunomiya, Shin ^a   Sakata, Yoichi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

2 Plasmin inhibitor; Coagulopathy; Critically ill; Early diagnosis; Platelet; Protein C; Sepsis

Indexed keywords

ALPHA 2 ANTIPLASMIN; FIBRINOGEN; PLASMINOGEN; PROTEIN C; THROMBIN ANTITHROMBIN COMPLEX;

AGED; ARTICLE; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DISEASE COURSE; DISEASE MARKER; DISEASE SEVERITY; FEMALE; HEMOSTASIS; HUMAN; INTERNATIONAL NORMALIZED RATIO; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROGNOSIS; PROTHROMBIN TIME; SEPSIS; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

COAGULOPATHY; CRITICALLY ILL; EARLY DIAGNOSIS; PLATELET; PROTEIN C; SEPSIS; Α(2)-PLASMIN INHIBITOR;

AGED; BIOLOGICAL MARKERS; BLOOD COAGULATION DISORDERS; CRITICAL ILLNESS; FEMALE; HEMOSTASIS; HUMANS; MALE; PLATELET COUNT; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SEPSIS;

EID: 84883556539     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2012.10.069     Document Type: Article

References (37)

1. Kinasewitz G.T., Yan S.B., Basson B., et al. Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]. Crit Care 2004, 8:R82-90.
2. Levi M., Ten Cate H. Disseminated intravascular coagulation. N Engl J Med 1999, 341:586-592.
3. Fourrier F., Chopin C., Goudemand J., et al. Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest 1992, 101:816-823.
4. Dhainaut J.F., Yan S.B., Joyce D.E., et al. Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation. J Thromb Haemost 2004, 2:1924-1933.
5. Ten Cate H. Trombocytopenia: one of the markers of disseminated intravascular coagulation. Pathophysiol Haemost Thromb 2003, 33:413-416.
6. Wada H., Wakita Y., Nakase T., et al. Outcome of disseminated intravascular coagulation in relation to the score when treatment was begun. Mie DIC Study Group. Thromb Haemost 1995, 74:848-852.
7. Taylor F.B., Toh C.H., Hoots W.K., et al. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001, 86:1327-1330.
8. Oh D., Jang M.J., Lee S.J., et al. Evaluation of modified non-overt DIC criteria on the prediction of poor outcome in patients with sepsis. Thromb Res 2010, 126:18-23.
9. Lorente J.A., Garcia-Frade L.J., Landin L., et al. Time course of hemostatic abnormalities in sepsis and its relation to outcome. Chest 1993, 103:1536-1542.
10. Wada H., Sakuragawa N., Mori Y., et al. Hemostatic molecular markers before the onset of disseminated intravascular coagulation. Am J Hematol 1999, 60:273-278.
11. Levi M., Opal S.M. Coagulation abnormalities in critically ill patients. Crit Care 2006, 10:222.
12. Brun-Buisson C., Doyon F., Carlet J., et al. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. JAMA 1995, 274:968-974.
13. Bone R.C., Balk R.A., Cerra F.B., et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655.
14. Dellinger R.P., Levy M.M., Carlet J.M., et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008, 36:296-327.
15. Ohno H., Kosaki G., Kambayashi J., et al. FOY: [ethyl P-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. Thromb Res 1980, 19:579-588.
16. Nishiyama T., Matsukawa T., Hanaoka K. Is protease inhibitor a choice for the treatment of pre- or mild disseminated intravascular coagulation?. Crit Care Med 2000, 28:1419-1422.
17. Knaus W.A., Draper E.A., Wagner D.P., et al. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829.
18. Le Gall J.R., Lemeshow S., Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993, 270:2957-2963.
19. Vincent J.L., Moreno R., Takala J., et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22:707-710.
20. Wiedemann H.P., et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006, 354:2564-2575. National Heart L, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials N.
21. Dhainaut J.F., Shorr A.F., Macias W.L., et al. Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure. Crit Care Med 2005, 33:341-348.
22. Gando S., Iba T., Eguchi Y., et al. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med 2006, 34:625-631.
23. Kinasewitz G.T., Zein J.G., Lee G.L., et al. Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis. Crit Care Med 2005, 33:2214-2221.
24. Madoiwa S., Nunomiya S., Ono T., et al. Plasminogen activator inhibitor 1 promotes a poor prognosis in sepsis-induced disseminated intravascular coagulation. Int J Hematol 2006, 84:398-405.
25. Abraham E., Singer M. Mechanisms of sepsis-induced organ dysfunction. Crit Care Med 2007, 35:2408-2416.
26. Levi M., Schultz M. Coagulopathy and platelet disorders in critically ill patients. Minerva Anestesiol 2010, 76:851-859.
27. Crowther M.A., Cook D.J., Meade M.O., et al. Thrombocytopenia in medical-surgical critically ill patients: prevalence, incidence, and risk factors. J Crit Care 2005, 20:348-353.
28. Moreau D., Timsit J.F., Vesin A., et al. Platelet count decline: an early prognostic marker in critically ill patients with prolonged ICU stays. Chest 2007, 131:1735-1741.
29. Mavrommatis A.C., Theodoridis T., Orfanidou A., et al. Coagulation system and platelets are fully activated in uncomplicated sepsis. Crit Care Med 2000, 28:451-457.
30. Zeerleder S., Hack C.E., Wuillemin W.A. Disseminated intravascular coagulation in sepsis. Chest 2005, 128:2864-2875.
31. Madoiwa S., Tanaka H., Nagahama Y., et al. Degradation of cross-linked fibrin by leukocyte elastase as alternative pathway for plasmin-mediated fibrinolysis in sepsis-induced disseminated intravascular coagulation. Thromb Res 2011, 127:349-355.
32. Asakura H., Ontachi Y., Mizutani T., et al. Decreased plasma activity of antithrombin or protein C is not due to consumption coagulopathy in septic patients with disseminated intravascular coagulation. Eur J Haematol 2001, 67:170-175.
33. Mavrommatis A.C., Theodoridis T., Economou M., et al. Activation of the fibrinolytic system and utilization of the coagulation inhibitors in sepsis: comparison with severe sepsis and septic shock. Intensive Care Med 2001, 27:1853-1859.
34. Nilsson G., Astermark J., Lethagen S., et al. Protein C levels can be forecasted by global haemostatic tests in critically ill patients and predict long-term survival. Thromb Res 2005, 116:15-24.
35. Sakata Y., Loskutoff D.J., Gladson C.L., et al. Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood 1986, 68:1218-1223.
36. Bannach F.G., Gutierrez-Fernandez A., Parmer R.J., et al. Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBPbeta). J Thromb Haemost 2004, 2:2205-2212.
37. Gabay C., Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999, 340:448-454.