Polypharmacy in nursing home residents with severe cognitive impairment: Results from the SHELTER Study

Alzheimer's and Dementia

Volumn 9, Issue 5, 2013, Pages 587-593

  Vetrano, Davide L ^a   Tosato, Matteo ^a   Colloca, Giuseppe ^a   Topinkova, Eva ^b   Fialova, Daniela ^b   Gindin, Jacob ^c   Van Der Roest, Henriëtte G ^d   Landi, Francesco ^a   Liperoti, Rosa ^a   Bernabei, Roberto ^a   Onder, Graziano ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF HAIFA   (Israel)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Nursing home; Older adults; Polypharmacy

Indexed keywords

ANALGESIC AGENT; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIBIOTIC AGENT; ANTIDEPRESSANT AGENT; ANTITHROMBOCYTIC AGENT; ANTIULCER AGENT; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CORTICOSTEROID; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; LAXATIVE; NEUROLEPTIC AGENT; NOOTROPIC AGENT; ORAL ANTIDIABETIC AGENT; PSYCHOTROPIC AGENT; VITAMIN D;

ADL DISABILITY; AGED; ARTICLE; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; DRUG USE; DYSPNEA; FEMALE; GASTROINTESTINAL SYMPTOM; HEALTH CARE FACILITY; HOSPITALIZATION; HUMAN; INTERMETHOD COMPARISON; ISCHEMIC HEART DISEASE; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; NURSING HOME PATIENT; NURSING HOME PERSONNEL; PAIN; PARKINSON DISEASE; POLYPHARMACY; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; VITAMIN SUPPLEMENTATION;

NURSING HOME; OLDER ADULTS; POLYPHARMACY;

AGED, 80 AND OVER; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; NURSING HOMES; POLYPHARMACY;

EID: 84883553821     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2012.09.009     Document Type: Article

References (39)

1. P.G. Lee, C. Cigolle, and C. Blaum The co-occurrence of chronic diseases and geriatric syndromes: the Health and Retirement Study J Am Geriatr Soc 57 2009 511 516
2. G. Onder, M. Petrovic, B. Tangiisuran, M.C. Meinardi, W.P. Markito-Notenboom, and A. Somers Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score Arch Intern Med 170 2010 1142 1148
3. M. Van den Akker, F. Buntinx, J.F. Metsemakers, S. Roos, and J.A. Knottnerus Multimorbidity in general practice: prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases J Clin Epidemiol 51 1998 367 375 (Pubitemid 28223302)
4. R. Bernabei, A. Caputi, L. Di Cioccio, M. Fini, P.F. Gallo, and N. Marchionni Need for redesigning pharmacologic research in older individuals: a position statement of the Geriatric Working Group of the Agenzia Italiana del Farmaco (AIFA) J Gerontol A Biol Sci Med Sci 66 2011 66 67
5. S. Cho, S.W. Lau, V. Tandon, K. Kumi, E. Pfuma, and D.R. Abernethy Geriatric drug evaluation: where are we now and where should we be in the future? Arch Intern Med 171 2011 937 940
6. D. Fusco, F. Lattanzio, M. Tosato, A. Corsonello, A. Cherubini, and S. Volpato Development of CRIteria to assess appropriate Medication use among Elderly complex patients (CRIME) project: rationale and methodology Drugs Aging 26 2009 3 13
7. D.M. Zulman, J.B. Sussman, X. Chen, C.T. Cigolle, C.S. Blaum, and R.A. Hayward Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials J Gen Intern Med 26 2011 783 790
8. E. Fuller-Thomson, B. Yu, A. Nuru-Jeter, J.M. Guralnik, and M. Minkler Basic ADL disability and functional limitation rates among older Americans from 2000-2005: the end of the decline? J Gerontol A Biol Sci Med Sci 64 2009 1333 1336
9. C.P. Ferri, M. Prince, C. Brayne, H. Brodaty, L. Fratiglioni, and M. Ganguli Global prevalence of dementia: a Delphi consensus study Lancet 366 2005 2112 2117 (Pubitemid 41797645)
10. T.R. Fried, M.E. Tinetti, and L. Iannone Primary care clinicians' experiences with treatment decision making for older persons with multiple conditions Arch Intern Med 171 2011 75 80
11. E.D. Huey, J.L. Taylor, P. Luu, J. Oehlert, and J.R. Tinklenberg Factors associated with use of medications with potential to impair cognition or cholinesterase inhibitors among Alzheimer's disease patients Alzheimers Dement 2 2006 314 321 (Pubitemid 44548892)
12. D.J. Brauner, J.C. Muir, and G.A. Sachs Treating nondementia illnesses in patients with dementia JAMA 283 2000 3230 3235 (Pubitemid 30422041)
13. G. Onder, R. Liperoti, D. Fialova, E. Topinkova, M. Tosato, and P. Danese Polypharmacy in nursing home in Europe: results from the SHELTER Study J Gerontol A Biol Sci Med Sci 67 2012 698 704
14. S.E. Bronskill, S.S. Gill, J.M. Paterson, C.M. Bell, G.M. Anderson, and P.A. Rochon Exploring variation in rates of polypharmacy across long-term care homes J Am Med Dir Assoc 13 2012 309.e15 309.e21
15. L.L. Dwyer, B. Han, D.A. Woodwell, and E.A. Rechtsteiner Polypharmacy in nursing home residents in the United States: results of the 2004 National Nursing Home Survey Am J Geriatr Pharmacother 8 2010 63 72
16. G. Onder, I. Carpenter, H. Finne-Soveri, J. Gindin, D. Frijters, and J.C. Henrard Assessment of nursing home residents in Europe: the Services and Health for Elderly in Long TERm care (SHELTER) Study BMC Health Serv Res 12 2012 5
17. V. Mor A comprehensive clinical assessment tool to inform policy and practice: applications of the minimum data set Med Care 42 2004 III50 III59
18. R. Bernabei, F. Landi, G. Onder, R. Liperoti, and G. Gambassi Second and third generation assessment instruments: the birth of standardization in geriatric care J Gerontol A Biol Sci Med Sci 63 2008 308 313 (Pubitemid 351738436)
19. F. Landi, A. Sgadari, G. Zuccala, M. Pahor, P. Carbonin, and R. Bernabei A brief training program on resident assessment instrument improves motivation of nursing home staff J Nutr Health Aging 3 1999 24 28 (Pubitemid 129728792)
20. The Anatomical Therapeutic Chemical (ATC) classification system by World Health Organization. Available at http://www.whocc.no. Accessed November 29, 2011.
21. D.W. Kaufman, J.P. Kelly, L. Rosenberg, T.E. Anderson, and A.A. Mitchell Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey JAMA 287 2002 337 344 (Pubitemid 34251967)
22. J. Jyrkkä, H. Enlund, M.J. Korhonen, R. Sulkava, and S. Hartikainen Polypharmacy status as an indicator of mortality in an elderly population Drugs Aging 26 2009 1039 1048
23. S.I. Haider, K. Johnell, G.R. Weitoft, M. Thorslund, and J. Fastbom The influence of educational level on polypharmacy and inappropriate drug use: a register-based study of more than 600,000 older people J Am Geriatr Soc 57 2009 62 69
24. B. Hovstadius, K. Hovstadius, B. Astrand, and G. Petersson Increasing polypharmacy: an individual-based study of the Swedish population 2005-2008 BMC Clin Pharmacol 10 2010 16
25. J.N. Morris, B.E. Fries, D.R. Mehr, C. Hawes, C. Phillips, and V. Mor The MDS cognitive performance scale J Gerontol 49 1994 174 182
26. F. Landi, E. Tua, G. Onder, B. Carrara, A. Sgadari, and C. Rinaldi Minimum data set for home care: a valid instrument to assess frail older people living in the community Med Care 38 2000 1184 1190
27. J.M. Teno, S.L. Mitchell, P.L. Gozalo, D. Dosa, A. Hsu, and O. Intrator Hospital characteristics associated with feeding tube placement in nursing home residents with advanced cognitive impairment JAMA 303 2010 544 550
28. P. Gozalo, J.M. Teno, S.L. Mitchell, J. Skinner, J. Bynum, and D. Tyler End-of-life transitions among nursing home residents with cognitive issues N Engl J Med 365 2011 1212 1221
29. J.N. Morris, B.E. Fries, and S.A. Morris Scaling ADL's within the MDS J Gerontol 4 1999 M546 M553
30. J.A. Hanley, A. Negassa, M.D. Edwardes, and J.E. Forrester Statistical analysis of correlated data using generalized estimating equations: an orientation Am J Epidemiol 157 2003 364 375 (Pubitemid 36196757)
31. D.T. Lau, N.D. Mercaldo, A.T. Harris, E. Trittschuh, J. Shega, and S. Weintraub Polypharmacy and potentially inappropriate medication use among community-dwelling elders with dementia Alzheimer Dis Assoc Disord 24 2010 56 63
32. D.M. Blass, B.S. Black, H. Phillips, T. Finucane, A. Baker, and D. Loreck Medication use in nursing home residents with advanced dementia Int J Geriatr Psychiatry 23 2008 490 496 (Pubitemid 351722109)
33. G. Onder, G. Gambassi, C.J. Scales, M. Cesari, C.D. Vedova, and F. Landi Adverse drug reactions and cognitive function among hospitalized older adults Eur J Clin Pharmacol 58 2002 371 377 (Pubitemid 34983929)
34. M. Lee, and J. Chodosh Dementia and life expectancy: what do we know? J Am Med Dir Assoc 10 2009 466 471
35. H.M. Holmes Rational prescribing for patients with a reduced life expectancy Clin Pharmacol Ther 85 2009 103 107
36. G. Onder, F. Lattanzio, M. Battaglia, F. Cerullo, R. Sportiello, and R. Bernabei The risk of adverse drug reactions in older patients: beyond drug metabolism Curr Drug Metab 12 2011 647 651
37. E.R. Hajjar, A.C. Cafiero, and J.T. Hanlon Polypharmacy in elderly patients Am J Geriatr Pharmacother 5 2007 345 351
38. T. Søeborg, L.H. Basse, and B. Halling-Sørensen Risk assessment of topically applied products Toxicology 236 2007 140 148 (Pubitemid 46779139)
39. M.E. Müller, N. van der Velde, J.W. Krulder, and T.J. van der Cammen Syncope and falls due to timolol eye drops BMJ 332 2006 960 961 (Pubitemid 44365557)