Tipepidine activates VTA dopamine neuron via inhibiting dopamine D2 receptor-mediated inward rectifying K+ current

Neuroscience

Volumn 252, Issue , 2013, Pages 24-34

  Hamasaki, R ^a   Shirasaki, T ^a   Soeda, F ^a   Takahama, K ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Acutely dissociated neuron; Dopamine; G protein coupled inwardly rectifying potassium channel; Patch clamp; Tipepidine; Ventral tegmental area

Indexed keywords

BACLOFEN; DOPAMINE; DOPAMINE 2 RECEPTOR; GUANOSINE TRIPHOSPHATE; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; RACLOPRIDE; TERTIAPIN; TIPEPIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; HYPERPOLARIZATION; IC 50; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SINGLE DRUG DOSE; VENTRAL TEGMENTUM; VOLTAGE CLAMP;

5-HT; ACUTELY DISSOCIATED NEURON; BACLOFEN-INDUCED CURRENT; DA; DOPAMINE; DOPAMINE D(2) RECEPTOR-MEDIATED GIRK CURRENT; DOPAMINE-INDUCED CURRENT; G PROTEIN-COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G-PROTEIN-COUPLED INWARDLY RECTIFYING POTASSIUM; G-PROTEIN-COUPLED RECEPTOR; GIRK; GPCR; HYPERPOLARIZATION-ACTIVATED CATION CURRENT; I(BACLOFEN); I(DA(GIRK)); I(DA); I(H); INHIBITORY POSTSYNAPTIC CURRENTS; IPSCS; NA; NAC; NAT; NORADRENALINE; NORADRENALINE TRANSPORTER; NUCLEUS ACCUMBENS; OBSESSIVE-COMPULSIVE DISORDER; OCD; PATCH CLAMP; PB; PHOSPHATE BUFFER; S.E.M.; SEROTONIN; SEROTONIN TRANSPORTER; SERT; SNC; STANDARD ERROR OF THE MEAN; SUBSTANTIA NIGRA PARS COMPACTA; TBS; TBST; TH; TIPEPIDINE; TRIS-BUFFERED SALINE; TRITONX-100 IN TBS; TYROSINE HYDROXYLASE; VENTRAL TEGMENTAL AREA; VTA;

ANIMALS; ANTIDEPRESSIVE AGENTS; DOPAMINERGIC NEURONS; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; IMMUNOHISTOCHEMISTRY; PATCH-CLAMP TECHNIQUES; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; VENTRAL TEGMENTAL AREA;

EID: 84883542073     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.07.044     Document Type: Article

References (54)

1. Adell A., Artigas F. The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems. Neurosci Biobehav Rev 2004, 28:415-431.
2. Akaike N., Harata N. Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. Jpn J Physiol 1994, 44:433-473.
3. Amano T., Matsubayashi H., Seki T., Sasa M., Sakai N. Repeated administration of methamphetamine causes hypersensitivity of D2 receptor in rat ventral tegmental area. Neurosci Lett 2003, 347:89-92.
4. Arencibia-Albite F., Paladini C., Williams J.T., Jimenez-Rivera C.A. Noradrenergic modulation of the hyperpolarization-activated cation current (Ih) in dopamine neurons of the ventral tegmental area. Neuroscience 2007, 149:303-314.
5. Arim J., Kubo C., Ishibashi H., Akaike N. α2-Adrenoceptor-mediated potassium currents in acutely dissociated rat locus coeruleus neurons. J Physiol 1998, 508:57-66.
6. Bewernick B.H., Hurlemann R., Matusch A., Kayser S., Grubert C., Hadrysiewicz B., Axmacher N., Lemke M., Cooper-Mahkorn D., Cohen M.X., Brockmann H., Lenartz D., Sturm V., Schlaepfer T.E. Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. Biol Psychiatry 2010, 67:110-116.
7. Cassano P., Lattanzi L., Soldani F., Navari S., Battistini G., Gemignani A., Cassano G.B. Pramipexole in treatment-resistant depression: an extended follow-up. Depress Anxiety 2004, 20:131-138.
8. Chao S.Z., Ariano M.A., Peterson D.A., Wolf M.E. D1 dopamine receptor stimulation increases GluR1 surface expression in nucleus accumbens neurons. J Neurochem 2002, 83:704-712.
9. Courtney N.A., Mamaligas A.A., Ford C.P. Species differences in somatodendritic dopamine transmission determine D2-autoreceptor-mediated inhibition of ventral tegmental area neuron firing. J Neurosci 2012, 32:13520-13528.
10. Cruz H.G., Ivanova T., Lunn M.L., Stoffel M., Slesinger P.A., Lüscher C. Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system. Nat Neurosci 2004, 7(2):153-159.
11. Denys D., Mantione M., Figee M., van den Munckhof P., Koerselman F., Westenberg H., Bosch A., Schuurman R. Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. Arch Gen Psychiatry 2010, 67:1061-1068.
12. Ford Ford.C.P., Beckstead M.J., Williams J.T. Kappa opioid inhibition of somatodendritic dopamine inhibitory postsynaptic currents. J Neurophysiol 2007, 97:883-891.
13. Hamao K., Inoue M., Kawaura K., Honda S., Soeda F., Shirasaki T., Takahama K. Tipepidine increasing dopamine levels in nucleus accumbens does not produce reverse tolerance in rats. J Pharmacol Sci 2011, 115(Suppl. 1):197P.
14. Herdegen T., Leah J.D. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res Brain Res Rev 1998, 28:370-490.
15. Higuchi H., Kamata M., Sugawara Y., Yoshida K. Remarkable effect of selegiline (l-deprenyl), a selective monoamine oxidase type-B inhibitor, in a patient with severe refractory depression: a case report. Clin Neuropharmacol 2005, 28:191-192.
16. Honda S., Kawaura K., Soeda F., Shirasaki T., Takahama K. The potent inhibitory effect of tipepidine on marble-burying behavior in mice. Behav Brain Res 2010, 216:308-312.
17. Hopf F.W., Martin M., Chen B.T., Bowers M.S., Mohamedi M.M., Bonci A. Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro. J Neurophysiol 2007, 98:2297-2310.
18. Horn R., Marty A. Muscarinic activation of ionic currents measured by a new whole-cell recording method. J Gen Physiol 1988, 92:145-159.
19. Ichimaru Y., Egawa T., Sawa A. 5-HT1A-receptor subtype mediates the effect of fluvoxamine, a selective serotonin reuptake inhibitor, on marble-burying behavior in mice. Jpn J Pharmacol 1995, 68:65-70.
20. + current by dextromethorphan in rat dorsal raphe neurones. Neuropharmacology 2000, 39:2302-2308.
21. + current in acutely dissociated rat dorsal raphe neurones. Br J Pharmacol 1998, 124:897-904.
22. Kalivas P.W. Neurotransmitter regulation of dopamine neurons in the ventral tegmental area. Brain Res Rev 1993, 18:75-113.
23. Kaneda M., Nakamura H., Akaike N. Mechanical and enzymatic isolation of mammalian CNS neurons. Neurosci Res 1988, 5:299-315.
24. + channel mRNAs are differentially expressed in the adult rat brain. J Neurosci 1996, 16:3559-3570.
25. Kawahara R., Soeda F., Kawaura K., Honda S., Miki R., Noguchi T., Shirasaki T., Takahama K. Effect of tipepidine with novel antidepressant-like action on c-fos-like protein expression in rat brain. Brain Res 2013, 1513:135-142.
26. Kawaura K., Honda S., Soeda F., Shirasaki T., Takahama K. A novel antidepressant like action of drugs possessing GIRK channel blocking action in rats. Yakugaku Zasshi 2010, 130:699-705. (in Japanese).
27. Kawaura K., Miki R., Urashima Y., Kawahara R., Soeda F., Shirasaki T., Takahama K. Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test. Behav Brain Res 2012, 226:381-385.
28. Kawaura K., Ogata Y., Inoue M., Honda S., Soeda F., Shirasaki T., Takahama K. The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats. Behav Brain Res 2009, 205:315-318.
29. Kawaura K., Urashima Y., Miki R., Honda S., Soeda F., Shirasaki T., Takahama K. Studies on the mechanism of a novel antidepressant-like action of tipepidine in rats. J Pharmacol Sci 2011, 115(Suppl. 1):197P.
30. Kim K.M., Nakajima Y., Nakajima S. G protein-coupled inward rectifier modulated by dopamine agonists in cultured substantia nigra neurons. Neuroscience 1995, 69:1145-1158.
31. Kitamura Y., Araki H., Gomita Y. Influence of ACTH on the effects of imipramine, desipramine and lithium on duration of immobility of rats in the forced swim test. Pharmacol Biochem Behav 2002, 71:63-69.
32. Kunkel M.T., Peralta E.G. Identification of domains conferring G protein regulation on inward rectifier potassium channels. Cell 1995, 83:443-449.
33. Liu Z., Bunney E.B., Appel S.B., Brodie M.S. Serotonin reduces the hyperpolarization-activated current (Ih) in ventral tegmental area dopamine neurons: involvement of 5-HT2 receptors and protein kinase C. J Neurophysiol 2003, 90:3201-3212.
34. Lammel S., Hetzel A., Häckel O., Jones I., Liss B., Roeper J. Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron 2008, 57:760-773.
35. Lammel S., Ion D.I., Roeper J., Malenka R.C. Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron 2011, 70:855-862.
36. Londei T., Valentini A.M., Leone V.G. Investigative burying by laboratory mice may involve non-functional, compulsive, behaviour. Behav Brain Res 1998, 94:249-254.
37. Mangiavacchi S., Wolf M.E. D1 dopamine receptor stimulation increases the rate of AMPA receptor insertion onto the surface of cultured nucleus accumbens neurons through a pathway dependent on protein kinase A. J Neurochem 2004, 88:1261-1271.
38. Margolis E.B., Lock H., Hjelmstad G.O., Fields H.L. The ventral tegemental area revisited: is there an electrophysiological marker for dopaminergic neurons. J Physiol 2006, 577:907-924.
39. + conductance by histamine H1 and H2 receptors in neurones dissociated from rat neostriatum. J Physiol (Lond) 1994, 480:233-245.
40. Nair-Roberts R.G., Chatelain-Badie S.D., Benson E., White-Cooper H., Bolam J.P., Ungless M.A. Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat. Neuroscience 2008, 152:1024-1031.
41. Neuhoff H., Neu A., Liss B., Roeper J. I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. J Neurosci 2002, 22:1290-1302.
42. Njung'e K., Handley S. Evaluation of marble-burying behavior as a model of anxiety. Pharmacol Biochem Behav 1991, 38:63-67.
43. North R.A. Twelfth Gaddum memorial lecture. Drug receptors and the inhibition of nerve cells. Br J Pharmacol 1989, 98:13-28.
44. Okamoto T., Harnett M.T., Morikawa H. Hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice. J Neurophysiol 2006, 95:619-626.
45. + currents through a cAMP-dependent protein kinase A-independent mechanism. Neuroscience 2010, 167:678-690.
46. Rishal I., Porozov Y., Yakubovich D., Varon D., Dascal N. Gβγ-dependent and Gβγ-independent basal activity in GIRK channels. J Biol Chem 2005, 280:16685-16694.
47. + channel GIRK2. Proc Natl Acad Sci USA 1997, 94:923-927.
48. Slattery D.A., Hudson A.L., Nutt D.J. Invited review: the evolution of antidepressant mechanisms. Fundam Clin Pharmacol 2004, 18:1-21.
49. Sodickson D.L., Bean B.P. GABAB receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons. J Neurosci 1996, 16:930-938.
50. Takahama K., Shirasaki T., Soeda F. Central mechanisms: neuronal mechanisms of action centrally acting antitussives using electrophysiological and neurochemical study approaches. Handbook of experimental pharmacology; pharmacology and therapeutics of cough 2009, vol. 187:219-240. Springer-Verlag, Berlin.
51. Tecuapetla F., Patel J.C., Xenias H., English D., Tadros I., Shah F., Berlin J., Deisseroth K., Rice M.E., Tepper J.M., Koos T. Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens. J Neurosci 2010, 30:7105-7110.
52. + channel in acutely dissociated rat substantia nigra neurons. Neuropharmacology 2000, 39:191-201.
53. Wickman K., Clapham D.E. Ion channel regulation by G proteins. Physiol Rev 1995, 75:865-885.
54. Wickman K., Nemec J., Gendler S.J., Clapham D.E. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron 1998, 20:103-114.