In-stream attenuation of neuro-active pharmaceuticals and their metabolites

Environmental Science and Technology

Volumn 47, Issue 17, 2013, Pages 9781-9790

  Writer, Jeffrey H ^a,b   Antweiler, Ronald C ^b   Ferrer, Imma ^a   Ryan, Joseph N ^a   Thurman, E Michael ^a  

^a University of Colorado   (United States)

^b U S GEOLOGICAL SURVEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL TRANSFORMATIONS; COLUMN EXPERIMENTS; LAGRANGIAN SAMPLING; PHARMACEUTICAL COMPOUNDS; PRIMARY MECHANISM; PSEUDO-FIRST-ORDER; STREAM SEDIMENTS; WASTEWATER LOADINGS;

AMIDES; BIOFILMS; BIOMOLECULES; LAGRANGE MULTIPLIERS; METABOLITES;

LOADING;

AMFEBUTAMONE; CARBAMAZEPINE; CITALOPRAM; DESVENLAFAXINE; DRUG METABOLITE; ERYTHRO HYDROBUPROPION; FLUOXETINE; LAMOTRIGINE; OXCARBAZEPINE; THREO HYDROBUPROPION; UNCLASSIFIED DRUG; VENLAFAXINE; WATER;

BIOFILM; LAGRANGIAN ANALYSIS; METABOLITE; NUMERICAL MODEL; PHARMACEUTICAL INDUSTRY; STREAM; TRANSFORMATION; WASTEWATER;

ARTICLE; ATTENUATION; BIODEGRADATION; BIOFILM; CONCENTRATION (PARAMETERS); ENVIRONMENTAL IMPACT; HYDROLOGY; LIMIT OF DETECTION; PARTICLE RESUSPENSION; PHOTOLYSIS; SEDIMENT; WASTE WATER;

BACTERIAL PHYSIOLOGICAL PHENOMENA; BIOFILMS; CENTRAL NERVOUS SYSTEM AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORADO; ENVIRONMENTAL MONITORING; GEOLOGIC SEDIMENTS; PERIPHERAL NERVOUS SYSTEM AGENTS; RIVERS; SEASONS; TANDEM MASS SPECTROMETRY; WASTE WATER; WATER POLLUTANTS, CHEMICAL;

EID: 84883501744     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es402158t     Document Type: Article

References (67)

1. Stagnitti, M. N. Antidepressant Use in the U.S. Civilian Non-Institutionalized Population, 2002; Statistical Brief #77; Agency for Healthcare Research and Quality: Rockville, Md, May 2005. http://meps.ahrq.gov/ mepsweb/data-files/publications/st77/stat77.pdf (accessed January 2012).
2. Miao, X. S.; Yang, J. J.; Metcalfe, C. D. Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plant Environ. Sci. Technol. 2005, 39, 7469-7475
3. Leclercq, M.; Mathieu, O.; Gomez, E.; Casellas, C.; Fenet, H.; Hillaire-Buys, D. Presence and fate of carbamazepine, oxcarbazepine, and seven of their metabolites at wastewater treatment plants Arch. Environ. Contam. Toxicol. 2009, 56, 408-415
4. Schultz, M. M.; Furlong, E. T.; Kolpin, D. W.; Werner, S. L.; Schoenfuss, H. L.; Barber, L. B.; Blazer, V.; Norris, D. O.; Vajda, A. M. Antidepressant pharmaceuticals in two U.S. effluent-impacted streams: Occurrence and fate in water and sediment, and selective uptake in fish neural tissue Environ. Sci. Technol. 2010, 44, 1918-1925
5. Lee, K. E.; Langer, S. K.; Barber, L. B.; Writer, J. H.; Ferrey, M. L.; Schoenfuss, H. L.; Furlong, E. T.; Foreman, W. T.; Gray, J. L.; ReVello, R. C.; Martinovic, D.; Woodruff, O. P.; Keefe, S. H.; Brown, G. K.; Taylor, H. E.; Ferrer, I.; Thurman, E. M. (2011, Endocrine active chemicals, pharmaceuticals, and other chemicals of concern in surface water, wastewater-treatment plant effluent, and bed sediment, and biological characteristics in selected streams, Minnesota-Design, methods, and data, 2009. U.S. Geological Survey Data Series 575, 2011, 54 p., with appendixes.
6. Benotti, M. J.; Trenholm, R. A.; Vanderford, B. J.; Holady, J. C.; Stanford, B. D.; Snyder, S. A. Pharmaceuticals and endocrine disrupting compounds in U.S. drinking water Environ Sci. Technol. 2008, 43, 597-603
7. Focazio, M. J.; Kolpin, D. W.; Barnes, K. K.; Furlong, E. T.; Meyer, M. T.; Zaugg, S. D.; Barber, L. B.; Thurman, M. E. A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States-II) Untreated drinking water sources Sci. Total Environ. 2008, 402, 201-216
8. Vulliet, E.; Cren-Olivé, C. Screening of pharmaceuticals and hormones at the regional scale, in surface and groundwaters intended to human consumption Eviron Pollut. 2011, 159, 2929-34
9. Oakes, K.; Coors, A.; Escher, B.; Fenner, K.; Garric, J.; Gust, M.; Knacker, T.; Kuster, A.; Kussatz, C.; Metcalfe, C.; Monteiro, S.; Moon, T.; Parrott, J.; Pery, A.; Ramil, M.; Tarazona, J. V.; Sanchez-Arguello, P.; Ternes, T.; Trudeau, V.; VanDer Kraak, G.; Servos, M. An environmental risk assessment for the serotonin re-uptake inhibitor fluoxetine: A case study utilizing the European risk assessment framework Integr. Environ. Assess. Manage. 2010, 6, 524-539
10. Brooks, B. W.; Turner, P. K.; Stanley, J. K.; Weston, J. J.; Glidewell, E. A.; Foran, C. M.; Slattery, M.; La Point, T. W.; Huggett, D. B. Waterborne and sediment toxicity of fluoxetine to select organisms Chemosphere 2003, 52, 135-142
11. Lister, A.; Regan, C.; Van Zwol, J.; Van Der Kraak, G. Inhibition of egg production in zebrafish by fluoxetine and municipal effluents: A mechanistic evaluation Aquat. Toxicol. 2009, 95, 320-329
12. Mennigen, J. A.; Lado, W. E.; Zamora, J. M.; Duarte-Guterman, P.; Langlois, V. S.; Metcalfe, C. D.; Chang, J. P.; Moon, T. W.; Trudeau., V. L. Waterborne fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratus Aquat. Toxicol. 2010, 100, 354-364
13. Lajeunesse, A.; Gagnon, C.; Gagné, F.; Louis, S.; Cejka, P.; Sauvé, S. Distribution of antidepressants and their metabolites in brook trout exposed to municipal wastewaters before and after ozone treatment-Evidence of biological effects Chemosphere 2011, 83, 564-71
14. Painter, M. M.; Buerkley, M. A.; Julius, M. L.; Vajda, A. M.; Norris, D. O.; Barber, L. B.; Furlong, E. T.; Schultz, M. M.; Schoenfuss, H. L. Antidepressants at environmentally relevant concentrations affect predator avoidance behavior of larval fathead minnows (Pimephales promelas) Environ. Toxicol. Chem. 2009, 28, 2677-84
15. Guler, Y.; Ford, A. T. Anti-depressants make amphipods see the light Aquat. Toxicol. 2010, 99, 397-404
16. Fong, P. P.; Hoy, C. H. Antidepressants (venlafaxine and citalopram) cause foot detachment from the substrate in freshwater snails at environmentally relevant concentrations Mar. Behav. Physiol. 2012, 45, 145-153
17. Schultz, M. M.; Painter, M. M.; Bartell, S. E.; Logue, A.; Furlong, E. T.; Werner, S. L.; Schoenfuss, H. L. Selective uptake and biological consequences of environmentally relevant antidepressant pharmaceutical exposures on male fathead minnows Aquat. Toxicol. 2011, 104, 38-47
18. Brooks, B. W.; Chambliss, C. K.; Stanley, J. K.; Ramirez, A. J.; Banks, K. E.; Johnson, 480 R.D.; Lewis, R. J. Determination of select antidepressants in fish from an effluent-dominated stream Environ. Toxicol. Chem. 2005, 24, 464-469
19. Schwarzenbach, R. P.; Escher, B. I.; Fenner, K.; Hofstetter, T. D.; Johnson, C. A.; von Gunten, U.; Wehrli, B. The challenge of micropollutants in aquatic systems Science 2006, 313, 1072-1077
20. Lam, M. W.; Young, C. J.; Brain, R. A.; Johnson, D. J.; Hanson, M. A.; Wilson, C. J.; Richards, S. M.; Solomon, K. R.; Mabury, S. A. Aquatic persistence of eight pharmaceuticals in a microcosm study Environ. Toxicol. Chem. 2004, 23, 1431-1440
21. Löffler, D.; Römbke, J.; Meller, M.; Ternes, T. A. Environmental fate of pharmaceuticals in water/sediment systems Environ. Sci. Technol. 2005, 39, 5209-5218
22. Kwon, J.; Armbrust, K. L. Persistence and fate of fluoxetine in aquatic environments Environ. Toxicol. Chem. 2006, 25, 2561-2568
23. Kwon, J.; Armbrust, K. L. Aqueous solubility, octanol-water partition coefficient, and sorption of five selective serotonin reuptake inhibitors to sediments and soils Bull. Environ. Contam. Toxicol. 2008, 81, 128-135
24. Stein, K.; Ramil, M.; Fink, G.; Sander, M.; Ternes, T. A. Analysis and sorption of psychoactive drugs onto sediment Environ. Sci. Technol. 2008, 42, 6415-6423
25. Yamamoto, H.; Nakamura, Y.; Moriguchi, S.; Nakamura, Y.; Honda, Y.; Tamura, I. Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment: Laboratory photolysis, biodegradation, and sorption experiments Water Res. 2009, 43, 351-362
26. Calisto, V.; Domingues, M. R. M.; Erny, G. L.; Esteves, V. I. Direct photodegradation of carbamazepine followed by micellar electrokinetic chromatography and mass spectrometry Water Res. 2011, 45, 1095-1104
27. Rúa-Gómez, P. C.; Püttmann, W. Degradation of lidocaine, tramadol, venlafaxine and the metabolites O-desmethyltramadol and O-desmethylvenlafaxine in surface waters Chemosphere 2013, 90, 1952-1959
28. Li, Z.; Gomez, E.; Fenet, H.; Chiron, S. Chiral signature of venlafaxine as a marker of biological attenuation processes Chemosphere 2013, 90, 1933-1938
29. Kunkel, U.; Radke, M. Reactive tracer test to evaluate the fate of pharmaceuticals in rivers Environ. Sci. Technol. 2011, 45, 6296-6302
30. Metcalfe, C. D.; Chu, S.; Judt, C.; Li, H.; Oakes, K. D.; Servos, M. R.; Andrews, D. M. Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed Environ. Toxicol. Chem. 2010, 29, 79-89
31. Barber, L. B.; Keefe, S. H.; Brown, G. K.; Furlong, E. T.; Gray, J. L.; Kolpin, D. W.; Meyer, M. T.; Sandstrom, M. W.; Zaugg, S. D. Persistence and potential effects of complex organic contaminant mixtures in wastewater-impacted streams Environ. Sci. Technol. 2013, 47, 2177-2188
32. Nelson, E. D.; Do, H.; Lewis, R. S.; Carr, S. A. Diurnal variability of pharmaceutical, personal care product, estrogen and alkylphenol concentrations in effluent from a tertiary wastewater treatment facility Environ. Sci. Technol. 2011, 45, 1228-1234
33. Murphy, S. F.; Verplanck, P. L.; Barber, L. B. Comprehenisive Water Quality of the Boulder Creek Watershed, Colorado, During High-Flow and Low-Flow Conditions; Water-Resources Investigations Report 03-4045; U.S. Geological Survey Water-Resources Investigations Report 03-4045, 2003, 198 p.
34. Barber, L. B.; Murphy, S. F.; Verplanck, P. L.; Sandstrom, M. W.; Taylor, H. E.; Furlong, E. T. Chemical loading into surface water along a hydrological, biogeochemical, and land use gradient: a holistic watershed approach Environ. Sci. Technol. 2006, 40, 475-486
35. Barbour, M. T.; Gerritsen, J.; Snyder, B. D.; Stribling, J. B. Rapid Bioassessment Protocols for Use in Streams and Wadeable Rivers: Periphyton, Benthic Macroinvertebrates and Fish, 2 nd ed.; EPA 841-B-99-002; Office of Water, U.S. Environmental Protection Agency; Washington, DC, 1999.
36. Runkel, R. L. A new metric for determining the importance of transient storage J. N. Am. Benthol. Soc. 2002, 21, 529-543
37. Garbarino, J. R.; Taylor, H. E. Inductively Coupled Plasma-Mass Spectrometric Method for the Determination of Dissolved Trace Elements in Natural Water; Open-File Report 94-358; U.S. Geological Survey: Denver, CO, 1995.
38. Taylor, H. E. Inductively Coupled Plasma-Mass Spectrometry: Practices and Techniques; Academic Press: San Diego, 2001.
39. Ferrer, I.; Thurman, E. M. Analysis of 100 pharmaceuticals and their degradates in water samples by liquid chromatography/quadropole time of flight mass spectrometry J. Chromatogr., A 2012, 1259, 148-157
40. Writer, J. H.; Ferrer, I.; Barber, L. B.; Thurman, E. M. Widespread occurrence of neuro-active pharmaceuticals and metabolites in 24 Minnesota rivers and wastewaters Sci. Total Environ. 2013, 461-462, 519-527
41. Hiemke, C.; Härtter, S. Pharmacokinetics of selective serotonin reuptake inhibitors Pharmacol. Ther. 2000, 85, 11-28
42. Ort, C.; Lawrence, M. G.; Rieckermann, J.; Joss, A. Sampling for pharmaceuticals and personal care products (PPCPs) and illicit drugs in wastewater systems: Are your conclusions valid? A critical review Environ. Sci. Technol. 2010, 44, 6024-6035
43. Barber, L. B.; Vajda, A. M.; Douville, C.; Norris, D. O.; Writer, J. H. Fish endocrine disruption responses to wastewater treatment plant infrastructure modifications and long-term variability in contaminant sources Environ. Sci. Technol. 2012, 46, 2121-2131
44. USGS 06730200 Boulder Creek at North 75th St. Near Boulder, CO. http://waterdata.usgs.gov/usa/nwis/uv?06730200 (accessed September 2011).
45. Runkel, R. L. One-Dimensional Transport with Inflow and Storage (OTIS): A Solute Transport Model for Streams and Rivers; Water-Resources Investigation Report 98-4018; U.S. Geological Survey: Denver, CO, 1998.
46. Riml, J.; Wörman, A.; Kunkel, U.; Radke, M. Evaluating the fate of six common pharmaceuticals using a reactive transport model: Insights from a stream tracer test Sci. Total Environ. 2013, 458, 344-354
47. Lajeunesse, A.; Smyth, S. A.; Barclay, K.; Sauvé, S.; Gagnon, C. Distribution of antidepressant residues in wastewater and biosolids following different treatment processes by municipal wastewater treatment plants in Canada Water Res. 2012, 46, 5600-5612
48. Lai, K. M.; Johnson, K. L.; Scrimshaw, M. D.; Lester, J. N. Binding of waterborne steroid estrogens to solid phases in river and estuarine systems Environ. Sci. Technol. 2000, 34, 3890-3894
49. Lewis, K. M.; Archer, R. D. pKa Values of estrone, 17β-estradiol and 2-methoxyestrone Steroids 1979, 34, 485-499
50. Ahel, M.; Giger, W. Aqueous solubility of alkylphenols and alkylphenol polyethoxylates Chemosphere 1993, 26, 1461-1470
51. Düring, R.; Krahe, S.; Garth, S. Sorption behavior of nonylphenol in terrestrial soils Environ. Sci. Technol. 2002, 36, 4052-4057
52. Writer, J. H.; Ryan, J. N.; Barber, L. B. Fate of 4-nonylphenol and 17β-estradiol in the Redwood River of Minnesota Environ. Sci. Technol. 2012, 46, 860-868
53. Wunder, D. B.; Bosscher, V. A.; Cok, R. C.; Hozalski, R. M. Sorption of antibiotics to biofilm Water Res. 2011, 45, 2270-80
54. Product Monograph "Prozac" fluoxetine hydrochloride, Eli Lily Canada, date revised July 25, 2012.
55. Product Monograph Celexa® citalopram hydrobromide, Lunbeck Canada, date revised November 17, 2006.
56. Product Monograph Effexor® venlafaxine hydrochloride, Pfizer Canada, date revised July 18, 2012.
57. Product Monograph Pristiq® desvenlafaxine succinate, Wyeth Canada, date revised January 28, 2009.
58. Bryant, S. G.; Guernsey, B. G.; Ingrim, N. B. Review of Bupropion Clin. Pharm. 1983, 2, 525-537
59. Product Monograph Lamictal® lamotrigine, GlaxoSmithKline, date revised July 3, 2009.
60. VCCLAB, Virtual Computational Chemistry Laboratory, 2005. http://www.vcclab.org (accessed July 2, 2012).
61. Ramil, M.; El Aref, T.; Fink, G.; Scheurer, M.; Ternes, T. A. Fate of beta blockers in aquatic-sediment systems: Sorption and biotransformation Environ. Sci. Technol. 2010, 44, 962-970
62. Droge, S. T. J.; Goss, K.-U. Effect of sodium and calcium cations on the ion-exchange affinity of organic cations for soil organic matter Environ. Sci. Technol. 2012, 46 (11) 5894-5901
63. Jouyban, A.; Khoubnasabjafari, M.; Chan, H. K.; Altria, K. D.; Clark, B. J. Predicting electrophoretic mobility of beta-blockers in a water-methanol based electrolyte system Chromatographia 2003, 57, 191-195
64. Rutherford, J. C. 1994 River Mixing; John Wiley and Sons, Ltd.: West Sussex, England.
65. Zaramella, M.; Marion, A.; Packman, A. I. Applicability of the transient storage model to the hyporheic exchange of metals J. Contam. Hydrol. 2006, 84, 21-35
66. Writer, J. H.; Ryan, J. N.; Barber, L. B.; Bradley, P. M. Biodegradation and attenuation of steroidal hormones and alkylphenols by stream biofilms and sediments Environ. Sci. Technol. 2011, 45, 4370-4376
67. Strzepek, K.; Yohe, G.; Neumann, J.; Boehlert, B. Characterizing changes in drought risk for the United States from climate change Environ. Res. Lett. 2010, 5, 1-9