Structural peculiarities of the (MHF1-MHF2)4 octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: A solution SAXS study

FEBS Letters

Volumn 587, Issue 18, 2013, Pages 2912-2917

  Wang, Wenjia ^a   Guo, Qiong ^b,c   Shtykova, Eleonora V ^d   Liu, Guangfeng ^a   Xu, Jianhua ^a   Teng, Maikun ^b,c   Liu, Peng ^a   Dong, Yuhui ^a  

^a INSTITUTE OF HIGH ENERGY PHYSICS   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d SHUBNIKOV INSTITUTE OF CRYSTALLOGRAPHY   (Russian Federation)

Author keywords

DNA binding patch; FANCM; Fanconi anaemia; MHF complex; SAXS

Indexed keywords

4 (MHF1 MHF2) PROTEIN; DOUBLE STRANDED DNA; FANCONI ANEMIA PROTEIN; MHF1 MHF2 FANCM FRAGMENT PROTEIN; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMATIN STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; DNA DAMAGE; DNA REPAIR; MOLECULAR MODEL; MOLECULAR WEIGHT; NANOANALYSIS; PARTICLE SIZE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

DNA BINDING PATCH; DOUBLE STRAND DNA; DSDNA; FA; FANCM; FANCONI ANAEMIA; FANCONI ANEMIA; ICLS; INTERSTRAND CROSSLINKS; MHF; MHF COMPLEX; MHF IN COMPLEX WITH A FRAGMENT OF FANCM; MHF-FANCM-F; MHF1-MHF2; MM; MOLECULAR MASS; SAXS; SEC; SIZE-EXCLUSION CHROMATOGRAPHY;

APOPTOSIS REGULATORY PROTEINS; BINDING SITES; CHROMATIN; DNA; DNA HELICASES; DNA-BINDING PROTEINS; GENE EXPRESSION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SCATTERING, SMALL ANGLE; SOLUTIONS; STATIC ELECTRICITY; TUMOR SUPPRESSOR PROTEINS; X-RAY DIFFRACTION;

EID: 84883488596     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.07.022     Document Type: Article

References (27)

1. A.D. D'Andrea, and M. Grompe The Fanconi anaemia/BRCA pathway Nat. Rev. Cancer 3 2003 23 34
2. J.P. de Winter, and H. Joenje The genetic and molecular basis of Fanconi anemia Mutat. Res. 668 2009 11 19
3. W. Wang Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins Nat. Rev. Genet. 8 2007 735 748
4. Y. Kee, and A.D. D'Andrea Expanded roles of the Fanconi anemia pathway in preserving genomic stability Genes Dev. 24 2010 1680 1694
5. F. Vaz Mutation of the RAD51C gene in a Fanconi anemia-like disorder Nat. Genet. 42 2010 406 409
6. Y. Kim Mutations of the SLX4 gene in Fanconi anemia Nat. Genet. 43 2011 142 146
7. C. Stoepker SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype Nat. Genet. 43 2011 138 141
8. L.H. Thompson, and J.M. Hinz Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights Mutat. Res. 668 2009 54 72
9. A.R. Meetei A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M Nat. Genet. 37 2005 958 963
10. K. Gari, C. Decaillet, A.Z. Stasiak, A. Stasiak, and A. Constantinou The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks Mol. Cell 29 2008 141 148
11. K. Gari, C. Decaillet, M. Delannoy, L. Wu, and A. Constantinou Remodeling of DNA replication structures by the branch point translocase FANCM Proc. Natl. Acad. Sci. 105 2008 16107 16112
12. T.R. Singh MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM Mol. Cell 37 2010 879 886
13. Z. Yan A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability Mol. Cell 37 2010 865 878
14. Yuyong. Tao Et al. The structure of the FANCM-MHF complex reveals physical features for functional assembly Nat. Commun. 3 2012 782
15. H.D. Mertens, and D.I. Svergun Structural characterization of proteins and complexes using small-angle X-ray solution scattering J. Struct. Biol. 172 1 2010 128 141
16. D.I. Svergun Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing Biophys. J. 76 1999 2879 2886
17. M.V. Petoukhov, and D.I. Svergun Global rigid body modelling of macromolecular complexes against small-angle scattering data Biophys. J. 89 2005 1237 1250
18. P.V. Konarev, M.V. Petoukhov, V.V. Volkov, and D.I. Svergun ATSAS 2.1, a program package for small-angle scattering data analysis J. Appl. Crystallogr. 39 2006 277 286
19. P.V. Konarev, V.V. Volkov, A.V. Sokolova, M.H.J. Koch, and D.I. Svergun PRIMUS: a Windows PC-based system for small-angle scattering data analysis J. Appl. Crystallogr. 36 2003 1277 1282
20. D.I. Svergun, C. Barberato, and M.H.J. Koch CRYSOL - a program to evaluate X-ray solution scattering of biological macromolecules from atomic coordinates J. Appl. Crystallogr. 28 1995 768 773
21. D.I. Svergun Determination of the regularization parameter in indirect-transform methods using perceptual criteria J. Appl. Crystallogr. 25 1992 495 503
22. V.V. Volkov, and D.I. Svergun Uniqueness of ab initio shape determination in small angle scattering J. Appl. Crystallogr. 36 2003 860 864
23. M.V. Petoukhov, and D.I. Svergun Global rigid body modelling of macromolecular complexes against small-angle scattering data Biophys. J. 89 2005 1237 1250
24. M.B. Kozin, and D.I. Svergun Automated matching of highand low-resolution structural models J. Appl. Crystallogr. 34 2001 33 41
25. E. Krissinel, and K. Henrick Inference of macromolecular assemblies from crystalline state J. Mol. Biol. 372 2007 774 797
26. Delano, W.L. (2002) PyMOL Molecular Viewer. < http://www.pymol.org/ >.
27. J.M. Kim, Y. Kee, A. Gurtan, and A.D. D'Andrea Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24 Blood 111 2008 5215 5222