메뉴 건너뛰기




Volumn 29, Issue 35, 2013, Pages 11102-11108

Oligonucleotide Adsorption Affects Phase Transition but Not Interdigitation of diC14-Amidine Bilayers

Author keywords

[No Author keywords available]

Indexed keywords

DIFFERENTIAL SCANNING CALORIMETRY; DYNAMIC LIGHT SCATTERING; LIPOSOMES; MAGNETIC MOMENTS; OLIGONUCLEOTIDES; RIGIDITY;

EID: 84883478506     PISSN: 07437463     EISSN: 15205827     Source Type: Journal    
DOI: 10.1021/la4016004     Document Type: Article
Times cited : (9)

References (60)
  • 2
    • 0035709416 scopus 로고    scopus 로고
    • Functional genomics and target validation approaches using antisense oligonucleotide technology
    • Dean, N. M. Functional genomics and target validation approaches using antisense oligonucleotide technology Curr. Opin. Biotechnol. 2001, 12, 622-625
    • (2001) Curr. Opin. Biotechnol. , vol.12 , pp. 622-625
    • Dean, N.M.1
  • 3
    • 19544379190 scopus 로고    scopus 로고
    • CpG motif act as a danger signal and provides a T helper type 1-biased microenvironment for DNA vaccination
    • Liu, L.; Zhou, X.; Liu, H.; Xiang, L.; Yuan, Z. CpG motif act as a danger signal and provides a T helper type 1-biased microenvironment for DNA vaccination Immunology 2005, 115, 223-230
    • (2005) Immunology , vol.115 , pp. 223-230
    • Liu, L.1    Zhou, X.2    Liu, H.3    Xiang, L.4    Yuan, Z.5
  • 4
    • 61749093073 scopus 로고    scopus 로고
    • Use of CpG oligonucelotides in treatment of asthma and allergic disease
    • Fonseca, D. E.; Kline, J. N. Use of CpG oligonucelotides in treatment of asthma and allergic disease Adv. Drug Delivery Rev. 2009, 61, 256-262
    • (2009) Adv. Drug Delivery Rev. , vol.61 , pp. 256-262
    • Fonseca, D.E.1    Kline, J.N.2
  • 5
    • 33749566621 scopus 로고    scopus 로고
    • Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/ cationic liposome complex
    • Kuramoto, Y.; Nishikawa, M.; Hyoudou, K.; Yamashita, F.; Hashida, M. Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/ cationic liposome complex J. Controlled Release 2006, 115, 226-233
    • (2006) J. Controlled Release , vol.115 , pp. 226-233
    • Kuramoto, Y.1    Nishikawa, M.2    Hyoudou, K.3    Yamashita, F.4    Hashida, M.5
  • 6
    • 0034757838 scopus 로고    scopus 로고
    • Antisense therapeutics: Lessons from early clinical trials
    • Flaherty, K. T.; Stevenson, J. P.; O'Dwyer, P. J. Antisense therapeutics: lessons from early clinical trials Curr. Opin. Oncol. 2001, 13, 499-505
    • (2001) Curr. Opin. Oncol. , vol.13 , pp. 499-505
    • Flaherty, K.T.1    Stevenson, J.P.2    O'Dwyer, P.J.3
  • 7
    • 0032500293 scopus 로고    scopus 로고
    • First "antisense" drug will treat CMV retinitis
    • Marwick, C. First "antisense" drug will treat CMV retinitis J. Am. Med. Assoc. 1998, 280, 871
    • (1998) J. Am. Med. Assoc. , vol.280 , pp. 871
    • Marwick, C.1
  • 8
    • 2942585676 scopus 로고    scopus 로고
    • Effective intracellular delivery of oligonucleotides in order to make sense of antisense
    • Shi, F.; Hoekstra, D. Effective intracellular delivery of oligonucleotides in order to make sense of antisense J, Controlled Release 2004, 97, 189-209
    • (2004) J, Controlled Release , vol.97 , pp. 189-209
    • Shi, F.1    Hoekstra, D.2
  • 9
    • 47249138782 scopus 로고    scopus 로고
    • Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
    • Juliano, R.; Alam, M. R.; Dixit, V.; Kang, H. Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides Nucleic Acids Res. 2008, 36, 4158-4171
    • (2008) Nucleic Acids Res. , vol.36 , pp. 4158-4171
    • Juliano, R.1    Alam, M.R.2    Dixit, V.3    Kang, H.4
  • 10
    • 0030041509 scopus 로고    scopus 로고
    • Double long-chain amidine liposome-mediated self replicating RNA transfection
    • El Ouahabi, A.; Pector, V.; Fuks, R.; Vandenbranden, M.; Ruysschaert, J. M. Double long-chain amidine liposome-mediated self replicating RNA transfection FEBS Lett. 1996, 380, 108-112
    • (1996) FEBS Lett. , vol.380 , pp. 108-112
    • El Ouahabi, A.1    Pector, V.2    Fuks, R.3    Vandenbranden, M.4    Ruysschaert, J.M.5
  • 12
    • 66149148678 scopus 로고    scopus 로고
    • Characterization of the cationic DiC(14)-amidine bilayer by mixed DMPC/ DiC(14)-amidine molecular dynamics simulations shows an interdigitated nonlamellar bilayer phase
    • Lensink, M. F.; Lonez, C.; Ruysschaert, J. M.; Vanderbranden, M. Characterization of the cationic DiC(14)-amidine bilayer by mixed DMPC/ DiC(14)-amidine molecular dynamics simulations shows an interdigitated nonlamellar bilayer phase Langmuir 2009, 25, 5230-5238
    • (2009) Langmuir , vol.25 , pp. 5230-5238
    • Lensink, M.F.1    Lonez, C.2    Ruysschaert, J.M.3    Vanderbranden, M.4
  • 13
    • 84858257958 scopus 로고    scopus 로고
    • Temperature-dependence of cationic lipid bilayer intermixing: Possible role of interdigitation
    • Oliveira, T. R.; Duarte, E. L.; Lamy, M. T.; Vandenbranden, M.; Ruysschaert, J. M.; Lonez, C. Temperature-dependence of cationic lipid bilayer intermixing: possible role of interdigitation Langmuir 2012, 28, 4640-4647
    • (2012) Langmuir , vol.28 , pp. 4640-4647
    • Oliveira, T.R.1    Duarte, E.L.2    Lamy, M.T.3    Vandenbranden, M.4    Ruysschaert, J.M.5    Lonez, C.6
  • 14
    • 77957325229 scopus 로고    scopus 로고
    • Acetonitrile induces nonsynchronous interdigitation and dehydration of dipalmitoylphosphatidylcholine bilayers
    • Wu, F. G.; Wang, N. N.; Tao, L. F.; Yu, Z. W. Acetonitrile induces nonsynchronous interdigitation and dehydration of dipalmitoylphosphatidylcholine bilayers J. Phys. Chem. B 2010, 114, 12685-12691
    • (2010) J. Phys. Chem. B , vol.114 , pp. 12685-12691
    • Wu, F.G.1    Wang, N.N.2    Tao, L.F.3    Yu, Z.W.4
  • 16
    • 0021676607 scopus 로고
    • Acyl chain interdigitation in saturated mixed-chain phosphatidylcholine bilayer dispersions
    • Hui, S. W.; Mason, J. T.; Huang, C. Acyl chain interdigitation in saturated mixed-chain phosphatidylcholine bilayer dispersions Biochemistry 1984, 23, 5570-5577
    • (1984) Biochemistry , vol.23 , pp. 5570-5577
    • Hui, S.W.1    Mason, J.T.2    Huang, C.3
  • 17
    • 0141754069 scopus 로고    scopus 로고
    • Mixtures of cationic lipid O-ethylphosphatidylcholine with membrane lipids and DNA: Phase diagrams
    • Koynova, R.; Macdonald, R. C. Mixtures of cationic lipid O-ethylphosphatidylcholine with membrane lipids and DNA: phase diagrams Biophys. J. 2003, 85, 2449-2465
    • (2003) Biophys. J. , vol.85 , pp. 2449-2465
    • Koynova, R.1    MacDonald, R.C.2
  • 18
    • 0034844825 scopus 로고    scopus 로고
    • Refined structure of 1,2-diacyl-P-O-ethylphosphatidylcholine bilayer membranes
    • Winter, I.; Pabst, G.; Rappolt, M.; Lohner, K. Refined structure of 1,2-diacyl-P-O-ethylphosphatidylcholine bilayer membranes Chem. Phys. Lipids 2001, 112, 137-150
    • (2001) Chem. Phys. Lipids , vol.112 , pp. 137-150
    • Winter, I.1    Pabst, G.2    Rappolt, M.3    Lohner, K.4
  • 20
    • 0023043180 scopus 로고
    • Hydrostatic pressure induces hydrocarbon chain interdigitation in single-component phospholipid bilayers
    • Braganza, L. F.; Worcester, D. L. Hydrostatic pressure induces hydrocarbon chain interdigitation in single-component phospholipid bilayers Biochemistry 1986, 25, 2591-2596
    • (1986) Biochemistry , vol.25 , pp. 2591-2596
    • Braganza, L.F.1    Worcester, D.L.2
  • 21
    • 45849112513 scopus 로고    scopus 로고
    • Pressure induces interdigitation differently in DPPC and DPPG
    • Singh, H.; Emberley, J.; Morrow, M. R. Pressure induces interdigitation differently in DPPC and DPPG Eur. Biophys. J. 2008, 37, 783-792
    • (2008) Eur. Biophys. J. , vol.37 , pp. 783-792
    • Singh, H.1    Emberley, J.2    Morrow, M.R.3
  • 22
    • 0021905618 scopus 로고
    • Comparative effects of short chain alcohols on lipid phase transitions
    • Rowe, E. S. Comparative effects of short chain alcohols on lipid phase transitions Alcohol 1985, 2, 173-176
    • (1985) Alcohol , vol.2 , pp. 173-176
    • Rowe, E.S.1
  • 23
    • 0021761592 scopus 로고
    • Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions
    • Simon, S. A.; McIntosh, T. J. Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions Biochim. Biophys. Acta 1984, 773, 169-172
    • (1984) Biochim. Biophys. Acta , vol.773 , pp. 169-172
    • Simon, S.A.1    McIntosh, T.J.2
  • 25
    • 0022433314 scopus 로고
    • Phase transitions and fatty acid spin label behavior in interdigitated lipid phases induced by glycerol and polymyxin
    • Boggs, J. M.; Rangaraj, G. Phase transitions and fatty acid spin label behavior in interdigitated lipid phases induced by glycerol and polymyxin Biochim. Biophys. Acta 1985, 816, 221-233
    • (1985) Biochim. Biophys. Acta , vol.816 , pp. 221-233
    • Boggs, J.M.1    Rangaraj, G.2
  • 26
    • 0024313791 scopus 로고
    • Thermodynamic properties of acyl chain and mesophase transitions for phospholipids in KSCN
    • Cunningham, B. A.; Tamura-Lis, W.; Lis, L. J.; Collins, J. M. Thermodynamic properties of acyl chain and mesophase transitions for phospholipids in KSCN Biochim. Biophys. Acta 1989, 984, 109-112
    • (1989) Biochim. Biophys. Acta , vol.984 , pp. 109-112
    • Cunningham, B.A.1    Tamura-Lis, W.2    Lis, L.J.3    Collins, J.M.4
  • 27
    • 0343119907 scopus 로고
    • Observation of an interdigitated gel phase in dipalmitoylphosphatidylglycerol bilayers treated ionene-6,6
    • Tirrell, D. A.; Turek, A. B.; Wilkinson, D. A.; McIntosh, T. J. Observation of an interdigitated gel phase in dipalmitoylphosphatidylglycerol bilayers treated ionene-6,6 Macromolecules 1985, 18, 1512-1513
    • (1985) Macromolecules , vol.18 , pp. 1512-1513
    • Tirrell, D.A.1    Turek, A.B.2    Wilkinson, D.A.3    McIntosh, T.J.4
  • 28
    • 0015241658 scopus 로고
    • Molecular motion in spin-labeled phospholipids and membranes
    • Hubbel, W. L.; McConnell, H. M. Molecular motion in spin-labeled phospholipids and membranes J. Am. Chem. Soc. 1971, 93, 314-326
    • (1971) J. Am. Chem. Soc. , vol.93 , pp. 314-326
    • Hubbel, W.L.1    McConnell, H.M.2
  • 29
    • 35148857675 scopus 로고    scopus 로고
    • Complexation of polycations to anionic liposomes: Composition and structure of the interfacial complexes
    • Sybachin, A. V.; Efimova, A. A.; Litmanovich, E. A.; Menger, F. M.; Yaroslavov, A. A. Complexation of polycations to anionic liposomes: composition and structure of the interfacial complexes Langmuir 2007, 23, 10034-10039
    • (2007) Langmuir , vol.23 , pp. 10034-10039
    • Sybachin, A.V.1    Efimova, A.A.2    Litmanovich, E.A.3    Menger, F.M.4    Yaroslavov, A.A.5
  • 33
    • 0034601242 scopus 로고    scopus 로고
    • Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1
    • Kazzaz, J.; Neidleman, J.; Singh, M.; Ott, G.; O'Hagan, D. T. Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1 J. Controlled Release 2000, 67, 347-356
    • (2000) J. Controlled Release , vol.67 , pp. 347-356
    • Kazzaz, J.1    Neidleman, J.2    Singh, M.3    Ott, G.4    O'Hagan, D.T.5
  • 36
    • 84861687871 scopus 로고    scopus 로고
    • Stable assemblies of cationic bilayer fragments and CpG oligonucleotide with enhanced immunoadjuvant activity in vivo
    • Rozenfeld, J. H. K.; Silva, S. R.; Ranéia, P.; Faquim-Mauro, E.; Carmona-Ribeiro, A. M. Stable assemblies of cationic bilayer fragments and CpG oligonucleotide with enhanced immunoadjuvant activity in vivo J. Controlled Release 2012, 160, 367-373
    • (2012) J. Controlled Release , vol.160 , pp. 367-373
    • Rozenfeld, J.H.K.1    Silva, S.R.2    Ranéia, P.3    Faquim-Mauro, E.4    Carmona-Ribeiro, A.M.5
  • 37
    • 0034703011 scopus 로고    scopus 로고
    • Biophysical and structural properties of DNA. DiC(14)-Amidine complexes. Influence of the DNA/lipid ratio
    • Pector, V.; Backmann, J.; Maes, D.; Vandenbranden, M.; Ruysschaert, J. M. Biophysical and structural properties of DNA.diC(14)-amidine complexes. Influence of the DNA/lipid ratio J. Biol. Chem. 2000, 275, 29533-29538
    • (2000) J. Biol. Chem. , vol.275 , pp. 29533-29538
    • Pector, V.1    Backmann, J.2    Maes, D.3    Vandenbranden, M.4    Ruysschaert, J.M.5
  • 38
    • 0000288058 scopus 로고
    • Electrostatic effects on lipid phase transitions: Membrane structure and ionic environment
    • Träuble, H.; Eibl, H. Electrostatic effects on lipid phase transitions: membrane structure and ionic environment Proc. Natl. Acad. Sci. U.S.A. 1974, 71, 214-219
    • (1974) Proc. Natl. Acad. Sci. U.S.A. , vol.71 , pp. 214-219
    • Träuble, H.1    Eibl, H.2
  • 39
    • 0017388353 scopus 로고
    • Lipid phase transitions and phase diagrams: I. Lipid phase transitions
    • Lee, A. G. Lipid phase transitions and phase diagrams: I. Lipid phase transitions Biochim. Biophys. Acta 1977, 472, 237-281
    • (1977) Biochim. Biophys. Acta , vol.472 , pp. 237-281
    • Lee, A.G.1
  • 40
    • 5444231376 scopus 로고    scopus 로고
    • Modification of a supported lipid bilayer by polyelectrolyte adsorption
    • Feng, Z. V.; Granick, S.; Gewirth, A. A. Modification of a supported lipid bilayer by polyelectrolyte adsorption Langmuir 2004, 20, 8796-8804
    • (2004) Langmuir , vol.20 , pp. 8796-8804
    • Feng, Z.V.1    Granick, S.2    Gewirth, A.A.3
  • 42
    • 0034917572 scopus 로고    scopus 로고
    • Structural characterization of dioctadecyldimethylammonium bromide dispersions by spin labels
    • Benatti, C. R.; Feitosa, E.; Fernandez, R. M.; Lamy-Freund, M. T. Structural characterization of dioctadecyldimethylammonium bromide dispersions by spin labels Chem. Phys. Lipids 2001, 111, 93-104
    • (2001) Chem. Phys. Lipids , vol.111 , pp. 93-104
    • Benatti, C.R.1    Feitosa, E.2    Fernandez, R.M.3    Lamy-Freund, M.T.4
  • 45
    • 0035118798 scopus 로고    scopus 로고
    • Studies of the structure and organization of cationic lipid bilayer membranes: Calorimetric, spectroscopic, and x-ray diffraction studies of linear saturated P-O-ethyl phosphatidylcholines
    • Lewis, R. N.; Winter, I.; Kriechbaum, M.; Lohner, K.; McElhaney, R. N. Studies of the structure and organization of cationic lipid bilayer membranes: calorimetric, spectroscopic, and x-ray diffraction studies of linear saturated P-O-ethyl phosphatidylcholines Biophys. J. 2001, 80, 1329-1342
    • (2001) Biophys. J. , vol.80 , pp. 1329-1342
    • Lewis, R.N.1    Winter, I.2    Kriechbaum, M.3    Lohner, K.4    McElhaney, R.N.5
  • 46
  • 47
    • 21644450877 scopus 로고    scopus 로고
    • Increasing surface charge density induces interdigitation in vesicles of cationic amphiphile and phosphatidylcholine
    • Ryhanen, S. J.; Alakoskela, J. M.; Kinnunen, P. K. Increasing surface charge density induces interdigitation in vesicles of cationic amphiphile and phosphatidylcholine Langmuir 2005, 21, 5707-5715
    • (2005) Langmuir , vol.21 , pp. 5707-5715
    • Ryhanen, S.J.1    Alakoskela, J.M.2    Kinnunen, P.K.3
  • 48
    • 34447342290 scopus 로고    scopus 로고
    • On the propensity of phosphatidylglycerols to form interdigitated phases
    • Pabst, G.; Danner, S.; Karmakar, S.; Deutsch, G.; Raghunathan, V. A. On the propensity of phosphatidylglycerols to form interdigitated phases Biophys. J. 2007, 93, 513-525
    • (2007) Biophys. J. , vol.93 , pp. 513-525
    • Pabst, G.1    Danner, S.2    Karmakar, S.3    Deutsch, G.4    Raghunathan, V.A.5
  • 49
    • 0034735701 scopus 로고    scopus 로고
    • Correlation between the effects of a cationic peptide on the hydration and fluidity of anionic lipid bilayers: A comparative study with sodium ions and cholesterol
    • Fernandez, R. M.; Lamy-Freund, M. T. Correlation between the effects of a cationic peptide on the hydration and fluidity of anionic lipid bilayers: a comparative study with sodium ions and cholesterol Biophys. Chem. 2000, 87, 87-102
    • (2000) Biophys. Chem. , vol.87 , pp. 87-102
    • Fernandez, R.M.1    Lamy-Freund, M.T.2
  • 50
    • 0035915492 scopus 로고    scopus 로고
    • Oligonucleotide lipoplexes: The influence of oligonucleotide composition on complexation
    • Meidan, V. M.; Glezer, J.; Amariglio, N.; Cohen, J. S.; Barenholz, Y. Oligonucleotide lipoplexes: the influence of oligonucleotide composition on complexation Biochim. Biophys. Acta 2001, 1568, 177-182
    • (2001) Biochim. Biophys. Acta , vol.1568 , pp. 177-182
    • Meidan, V.M.1    Glezer, J.2    Amariglio, N.3    Cohen, J.S.4    Barenholz, Y.5
  • 51
    • 3042545970 scopus 로고    scopus 로고
    • DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery: Zeta-potential measurements and electron spin resonance spectra
    • Ciani, L.; Ristori, S.; Salvati, A.; Calamai, L.; Martini, G. DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery: zeta-potential measurements and electron spin resonance spectra Biochim. Biophys. Acta 2004, 1664, 70-79
    • (2004) Biochim. Biophys. Acta , vol.1664 , pp. 70-79
    • Ciani, L.1    Ristori, S.2    Salvati, A.3    Calamai, L.4    Martini, G.5
  • 52
    • 35748933840 scopus 로고    scopus 로고
    • Effect of the preparation on the structural properties of oligonucleotide/cationic liposome complexes (lipoplexes) studied by electron spin resonance and zeta potential
    • Ciani, L.; Ristori, S.; Bonechi, C.; Rossi, C.; Martini, G. Effect of the preparation on the structural properties of oligonucleotide/cationic liposome complexes (lipoplexes) studied by electron spin resonance and zeta potential Biophys. Chem. 2007, 131, 80-87
    • (2007) Biophys. Chem. , vol.131 , pp. 80-87
    • Ciani, L.1    Ristori, S.2    Bonechi, C.3    Rossi, C.4    Martini, G.5
  • 53
    • 0034607265 scopus 로고    scopus 로고
    • Interaction of oligonucleotides with cationic lipids: The relationship between electrostatics, hydration and state of aggregation
    • Meidan, V. M.; Cohen, J. S.; Amariglio, N.; Hirsch-Lerner, D.; Barenholz, Y. Interaction of oligonucleotides with cationic lipids: the relationship between electrostatics, hydration and state of aggregation Biochim. Biophys. Acta 2000, 1464, 251-261
    • (2000) Biochim. Biophys. Acta , vol.1464 , pp. 251-261
    • Meidan, V.M.1    Cohen, J.S.2    Amariglio, N.3    Hirsch-Lerner, D.4    Barenholz, Y.5
  • 54
    • 33745457606 scopus 로고
    • EPR spectra of spin labels in lipid bilayers
    • Schindler, H.; Seelig, J. EPR spectra of spin labels in lipid bilayers J. Chem. Phys. 1973, 59, 1841-1850
    • (1973) J. Chem. Phys. , vol.59 , pp. 1841-1850
    • Schindler, H.1    Seelig, J.2
  • 55
    • 0000256168 scopus 로고
    • Berliner, L. J. Reuben, J. Plenum Press: New York
    • Marsh, D. (1989) in Spin labeling: Theory and Applications; Berliner, L. J.; Reuben, J., Eds.; Plenum Press: New York; Vol. 8, pp 255-303.
    • (1989) Spin Labeling: Theory and Applications , vol.8 , pp. 255-303
    • Marsh, D.1
  • 56
    • 65549127629 scopus 로고    scopus 로고
    • DNA alters the bilayer structure of cationic lipid diC14-amidine: A spin label study
    • Benatti, C. R.; Barroso, R. P.; Lonez, C.; Ruysschaert, J. M.; Lamy, M. T. DNA alters the bilayer structure of cationic lipid diC14-amidine: a spin label study Biochim. Biophys. Acta 2009, 1788, 1304-1309
    • (2009) Biochim. Biophys. Acta , vol.1788 , pp. 1304-1309
    • Benatti, C.R.1    Barroso, R.P.2    Lonez, C.3    Ruysschaert, J.M.4    Lamy, M.T.5
  • 58
    • 33745270715 scopus 로고    scopus 로고
    • Free diC14-amidine liposomes inhibit the TNF-alpha secretion induced by CpG sequences and lipopolysaccharides: Role of lipoproteins
    • Lonez, C.; Vandenbranden, M.; Ouali, M.; Legat, A.; Ruysschaert, J. M.; Elouahabi, A. Free diC14-amidine liposomes inhibit the TNF-alpha secretion induced by CpG sequences and lipopolysaccharides: role of lipoproteins Mol. Membr. Biol. 2006, 23, 227-234
    • (2006) Mol. Membr. Biol. , vol.23 , pp. 227-234
    • Lonez, C.1    Vandenbranden, M.2    Ouali, M.3    Legat, A.4    Ruysschaert, J.M.5    Elouahabi, A.6
  • 59
  • 60
    • 84355162032 scopus 로고    scopus 로고
    • The cationic lipid, diC14-amidine, extends the adjuvant properties of aluminum salts through a TLR-4 and caspase-1 independent mechanism
    • Wilmar, A.; Lonez, C.; Andrianne, M.; Ruysschaert, J. M.; Vandenbranden, M.; Leo, O.; Temmerman, S. The cationic lipid, diC14-amidine, extends the adjuvant properties of aluminum salts through a TLR-4 and caspase-1 independent mechanism Vaccine 2012, 30, 414-424
    • (2012) Vaccine , vol.30 , pp. 414
    • Wilmar, A.1    Lonez, C.2    Andrianne, M.3    Ruysschaert, J.M.4    Vandenbranden, M.5    Leo, O.6    Temmerman, S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.