Assessing the effect of immunosuppression on engraftment of pancreatic islets

Transplantation

Volumn 96, Issue 4, 2013, Pages 372-378

  Vallabhajosyula, Prashanth ^a,b   Hirakata, Atsushi ^a   Shimizu, Akira ^a   Okumi, Masayoshi ^a   Tchipashvili, Vaja ^c   Hong, Hanzhou ^a   Yamada, Kazuhiko ^a   Sachs, David H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c JOSLIN DIABETES CENTER   (United States)

Author keywords

Immunosuppression; Islet kidney; Pig; Transplant

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; GLUCOSE; PREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOTRANSPLANTATION; CONTROLLED STUDY; DIABETES MELLITUS; GLOMERULONEPHRITIS; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; GRAFT RECIPIENT; GRAFT REJECTION; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; INTRAVENOUS GLUCOSE TOLERANCE TEST; KIDNEY CAPSULE; KIDNEY FAILURE; MINOR HISTOCOMPATIBILITY COMPLEX; NEPHRECTOMY; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PANCREAS RESECTION; PRIORITY JOURNAL; TRANSPLANTATION TOLERANCE;

ANIMALS; AZATHIOPRINE; BLOOD GLUCOSE; CYCLOSPORINE; DIABETES MELLITUS, TYPE 1; DRUG THERAPY, COMBINATION; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS TRANSPLANTATION; MODELS, ANIMAL; PREDNISONE; SWINE; SWINE, MINIATURE; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 84883458767     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31829f7515     Document Type: Article

References (29)

1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230.
2. Ryan EA, Lakey JR, Rajotte RV, et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001; 50: 710.
3. Matsumoto S, Okitsu T, Iwanaga Y, et al. Follow-up study of the first successful living donor islet transplantation. Transplantation 2006; 82: 1629.
4. Farney AC, Najarian JS, Nakhleh RE, et al. Autotransplantation of dispersed pancreatic islet tissue combined with total or near-total pancreatectomy for treatment of chronic pancreatitis. Surgery 1991; 110: 427.
5. Farney AC, Najarian JS, Nakhleh R, et al. Long-term function of islet autotransplants. Transplant Proc 1992; 24: 969.
6. Gruessner RW, Sutherland DE, Dunn DL, et al. Transplant options for patients undergoing total pancreatectomy for chronic pancreatitis. J Am Coll Surg 2004; 198: 559.
7. Robertson RP, Lanz KJ, Sutherland DE, et al. Prevention of diabetes for up to 13 years by autoislet transplantation after pancreatectomy for chronic pancreatitis. Diabetes 2001; 50: 47.
8. Farney AC, Hering BJ, Nelson L, et al. No late failures of intraportal human islet autografts beyond 2 years. Transplant Proc 1998; 30: 420.
9. Teuscher AU, Kendall DM, Smets YF, et al. Successful islet autotransplantation in humans: Functional insulin secretory reserve as an estimate of surviving islet cell mass. Diabetes 1998; 47: 324.
10. Basadonna G, Kakizaki K, Merrell RC. Effect of cyclosporine on established islet autografts. J Surg Res 1986; 40: 450.
11. Fabian MC, Lakey JR, Rajotte RV, et al. The efficacy and toxicity of rapamycin in murine islet transplantation. In vitro and in vivo studies. Transplantation 1993; 56: 1137.
12. Ishizuka J, Gugliuzza KK, Wassmuth Z, et al. Effects of FK506 and cyclosporine on dynamic insulin secretion from isolated dog pancreatic islets. Transplantation 1993; 56: 1486.
13. Desai NM, Goss JA, Deng S, et al. Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: Local immunosuppression or islet toxicity? Transplantation 2003; 76: 1623.
14. Hirshberg B, Rother KI, Digon BJ 3rd, et al. Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: The National Institutes of Health experience. Diabetes Care 2003; 26: 3288.
15. Nanji SA, Shapiro AM. Islet transplantation in patients with diabetes mellitus: Choice of immunosuppression. BioDrugs 2004; 18: 315.
16. Hafiz MM, Faradji RN, Froud T, et al. Immunosuppression and procedure-related complications in 26 patients with type 1 diabetes mellitus receiving allogeneic islet cell transplantation. Transplantation 2005; 80: 1718.
17. Shapiro AM, Hao E, Lakey JR, et al. Diabetogenic synergism in canine islet autografts from cyclosporine and steroids in combination. Transplant Proc 1998; 30: 527.
18. Rilo HL, Carroll PB, Shapiro R, et al. Human islet transplantation: Results of the first 37 patients. Transplant Proc 1995; 27: 3162.
19. Ricordi C, Tzakis AG, Carroll PB, et al. Human islet isolation and allotransplantation in 22 consecutive cases. Transplantation 1992; 53: 407.
20. Menger MD, Wolf B, Jager S, et al. The influence of prednisolone on revascularization of pancreatic islet grafts. Transplant Proc 1990; 22: 2042.
21. Scharp DW, Lacy PE, Santiago JV, et al. Results of our first nine intraportal islet al.lografts in type 1, insulin-dependent diabetic patients. Transplantation 1991; 51: 76.
22. Socci C, Falqui L, Davalli AM, et al. Fresh human islet transplantation to replace pancreatic endocrine function in type 1 diabetic patients. Report of six cases. Acta Diabetol 1991; 28: 151.
23. Rosengard BR, Ojikutu CA, Guzzetta PC, et al. Induction of specific tolerance to class I-disparate renal allografts in miniature swine with cyclosporine. Transplantation 1992; 54: 490.
24. Kumagai N, O'Neil JJ, Barth RN, et al. Vascularized islet-cell transplantation in miniature swine. I. Preparation of vascularized islet kidneys. Transplantation 2002; 74: 1223.
25. Kumagai N, LaMattina JC, Kamano C, et al. Vascularized islet cell transplantation in miniature swine: Islet-kidney allografts correct the diabetic hyperglycemia induced by total pancreatectomy. Diabetes 2002; 51: 3220.
26. Vallabhajosyula P, Griesemer A, Yamada K, et al. Vascularized composite islet-kidney transplantation in a miniature swine model. Cell Biochem Biophys 2007; 48: 201.
27. Sachs DH, Leight G, Cone J, et al. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation 1976; 22: 559.
28. Mezrich JD, Haller GW, Arn JS, et al. Histocompatible miniature swine: An inbred large-animal model. Transplantation 2003; 75: 904.
29. O'Neil JJ, Stegemann JP, Nicholson DT, et al. The isolation and function of porcine islets from market weight pigs. Cell Transplant 2001; 10: 235.