An empirical comparison of low-dose extrapolation from points of departure (PoD) compared to extrapolations based upon methods that account for model uncertainty

Regulatory Toxicology and Pharmacology

Volumn 67, Issue 1, 2013, Pages 75-82

  Wheeler, Matthew W ^a   Bailer, A John ^b  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b MIAMI UNIVERSITY   (United States)

Author keywords

Benchmark doses; Cancer risk estimation; Dose response data; Linear extrapolation; Model averaging; Semi parametric methods

Indexed keywords

DIBENZO[A,L]PYRENE; PHOSPHORIC ACID TRIS(2,3 DIBROMOPROPYL) ESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CANCER RISK; CONTROLLED STUDY; DISEASE MODEL; EXPERIMENTAL ANIMAL; EXTRAPOLATION METHOD; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MATHEMATICAL PARAMETERS; MOUSE; NONHUMAN; PAPILLOMA; PARAMETRIC TEST; POINT OF DEPARTURE; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SQUAMOUS CELL PAPILLOMA; STOMACH CANCER; TOXICITY TESTING;

ANIMALIA;

BENCHMARK DOSES; CANCER RISK ESTIMATION; DOSE-RESPONSE DATA; LINEAR EXTRAPOLATION; MODEL AVERAGING; SEMI PARAMETRIC METHODS;

ANIMALS; BENCHMARKING; DOSE-RESPONSE RELATIONSHIP, DRUG; MODELS, BIOLOGICAL; RISK ASSESSMENT; UNCERTAINTY;

EID: 84883458525     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2013.06.006     Document Type: Article

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