Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer

Photodiagnosis and Photodynamic Therapy

Volumn 10, Issue 3, 2013, Pages 288-295

  Hagiya, Yuichiro ^a   Fukuhara, Hideo ^b   Matsumoto, Kentaro ^a   Endo, Yoshio ^c   Nakajima, Motowo ^d   Tanaka, Tohru ^d   Okura, Ichiro ^a   Kurabayashi, Atsushi ^b   Furihata, Mutsuo ^b   Inoue, Keiji ^b   Shuin, Taro ^b   Ogura, Shun ichiro ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

^d SBI Pharmaceuticals Co   (Japan)

Author keywords

5 Aminolevulinic acid; ABCG2; Bladder cancer; PEPT1; Photodynamic diagnosis; Protoporphyrin IX

Indexed keywords

AMINOLEVULINIC ACID; BREAST CANCER RESISTANCE PROTEIN; HEME OXYGENASE 1; MESSENGER RNA; PEPTIDE TRANSPORTER 1; PEPTIDE TRANSPORTER 2; PROTOPORPHYRIN;

ARTICLE; BLADDER CANCER; GENE EXPRESSION; GENE REPRESSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM;

5-AMINOLEVULINIC ACID; ABCG2; BLADDER CANCER; PEPT1; PHOTODYNAMIC DIAGNOSIS; PROTOPORPHYRIN IX;

AMINOLEVULINIC ACID; ATP-BINDING CASSETTE TRANSPORTERS; DRUG THERAPY, COMBINATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; METABOLIC CLEARANCE RATE; NEOPLASM PROTEINS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROTOPORPHYRINS; SIGNAL TRANSDUCTION; SYMPORTERS; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 84883449205     PISSN: 15721000     EISSN: 18731597     Source Type: Journal    
DOI: 10.1016/j.pdpdt.2013.02.001     Document Type: Article

References (23)

1. Krammer B., Plaetzer K. ALA and its clinical impact, from bench to bedside. Photochemical & Photobiological Sciences 2008, 7:283-289.
2. Kennedy J.C., Pottier R.H. Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology 1992, 14:275-292.
3. Tabata K., Ogura S., Okura I. Photodynamic efficiency of protoporphyrin IX: comparison of endogenous protoporphyrin IX induced by 5-aminolevulinic acid and exogenous porphyrin IX. Photochemistry and Photobiology 1997, 66:842-846.
4. Stummer W., Pichlmeier U., Meinel T., Wiestler O.D., Zanella F., Reulen H.J. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncology 2006, 7:392-401.
5. Inoue K., Fukuhara H., Shimamoto T., Kamada M., Iiyama T., Miyamura M., et al. Comparison between intravesical and oral administration of 5-aminolevulinic acid in the clinical benefit of photodynamic diagnosis for non-muscle invasive bladder cancer. Cancer 2012, 118:1062-1074.
6. Fukuhara H., Inoue K., Kuno T., Kamei M., Shimamoto T., Fukata S., et al. Preliminary experience of photodynamic diagnosis of positive margin during radical prostatectomy by oral 5-aminolevulnic acid. International Journal of Urology 2011, 18:585-591.
7. Matsuda T., Marugame T., Kamo K., Katanoda K., Ajiki W., Sobue T., et al. Cancer incidence and incidence rates in Japan in 2005: based on data from 12 population-based cancer registries in the Monitoring of Cancer Incidence in Japan (MCIJ) project. Japanese Journal of Clinical Oncology 2011, 41:139-147.
8. Wilby D., Thomas K., Ray E., Chappell B., O'Brien T. Bladder cancer: new TUR techniques. World Journal of Urology 2009, 27:309-312.
9. Cookson M.S., Herr H.W., Zhang Z.F., Soloway S., Sogani P.C., Fair W.R. The treated natural history of high risk superficial bladder cancer: 15-year outcome. Journal of Urology 1997, 158:62-67.
10. Lee R., Droller M.J. The natural history of bladder cancer. Implications for therapy. Urologic Clinics of North America 2000, 27:1-13.
11. Schulze M., Stotz N., Rassweiler J. Retrospective analysis of transurethral resection, second-look resection, and long-term chemo-metaphylaxis for superficial bladder cancer: indications and efficacy of a differentiated approach. Journal of Endourology 2007, 21:1533-1541.
12. Filbeck T., Pichlmeier U., Knuechel R., Wieland W.F., Rossler W. Clinically relevant reduction of recurrence of superficial bladder tumor with 5-aminolevulinic acid-induced fluorescence diagnosis. Results of a 5-year study. Urologe A 2003, 42:1366-1373.
13. Denzinger S., Burger M., Walter B., Knuechel R., Roessler W., Wieland W.F., et al. Clinically relevant reduction in risk of recurrence of superficial bladder cancer using 5-aminolevulinic acid-induced fluorescence diagnosis: 8-year results of prospective randomized study. Urology 2007, 69:675-679.
14. Ishikawa T., Nakagawa H., Hagiya Y., Nonoguchi N., Miyatake S., Kuroiwa T. Key role of human ABC transporter ABCG2 in photodynamic therapy and photodynamic diagnosis. Advances in Pharmacological Sciences 2010, 2010:587306.
15. Hagiya Y., Endo Y., Yonemura Y., Takahashi K., Ishizuka M., Abe F., et al. Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro. Photodiagnosis and Photodynamic Therapy 2012, 9:204-214.
16. Common Terminology Criteria for Adverse Events version 4.0.
17. Hagiya Y., Adachi T., Ogura S., An R., Tamura A., Nakagawa H., et al. Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy. Journal of Experimental Therapeutics and Oncology 2008, 7:153-167.
18. Ishizuka M., Hagiya Y., Mizokami Y., Honda K., Tabata K., Kamachi T., et al. Porphyrins in urine after administration of 5-aminolevulinic acid as a potential tumor marker. Photodiagnosis and Photodynamic Therapy 2011, 8:328-331.
19. Claydon P.E., Ackroyd R. 5-Aminolaevulinic acid-induced photodynamic therapy and photodetection in Barrett's esophagus. Diseases of the Esophagus 2004, 17:205-212.
20. Collinet P., Estevez J.P., Ascencio M., Farine M.O., Vinatier D., Cosson M., et al. Fluorescence diagnosis of cervical squamous intraepithelial lesions: a clinical feasability study. Photodiagnosis and Photodynamic Therapy 2007, 4:112-116.
21. Braathen L.R., Szeimies R.M., Basset-Seguin N., Bissonnette R., Foley P., Pariser D., et al. Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005. Journal of the American Academy of Dermatology 2007, 56:125-143.
22. Peng Q., Warloe T., Berg K., Moan J., Kongshaug M., Giercksky K.E., et al. 5-Aminolevulinic acid-based photodynamic therapy - clinical research and future challenges. Cancer 1997, 79:2282-2308.
23. +-coupled nutrient carriers coexpressed in the small intestine. Journal of Pharmacology and Experimental Therapeutics 2010, 332:220-228.