Transcriptional regulation of the alpha-1 type II collagen gene by nuclear factor κb/p65 and Sox9 in the chondrocytic phenotype of uterine carcinosarcomas

Human Pathology

Volumn 44, Issue 9, 2013, Pages 1780-1788

  Yoshida, Tsutomu ^a   Hashimura, Miki ^a   Kuwata, Takeshi ^b   Matsumoto, Toshihide ^a   Suzuki, Erina ^a   Tazo, Yuki ^a   Nakajima, Hiroyasu ^a   Inukai, Madoka ^a   Saegusa, Makoto ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

Author keywords

Clo2A1; NF B; Sox9; Uterine carcinosarcoma

Indexed keywords

COL2A1 PROTEIN; COLLAGEN TYPE 2; I KAPPA B; MESSENGER RNA; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARCINOSARCOMA; CHONDROGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; GENE REPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTRON; MALE; NEGATIVE FEEDBACK; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; TRANSCRIPTION REGULATION; TRANSIENT TRANSFECTION; UTERUS SARCOMA;

CLO2A1; NF-ΚB; SOX9; UTERINE CARCINOSARCOMA;

AGED; AGED, 80 AND OVER; CARCINOSARCOMA; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COLLAGEN TYPE II; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION; MIDDLE AGED; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOX9 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA; UTERINE NEOPLASMS;

EID: 84883445171     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2012.12.019     Document Type: Article

References (26)

1. W.G. McCluggage Malignant biphasic uterine tumors: carcinosarcomas or metaplastic carcinomas? J Clin Pathol 55 2002 321 325
2. H. Wada, T. Enomoto, and M. Fujita Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors Cancer Res 57 1997 5379 5385
3. L. Thompson, B. Chang, and S.H. Barsky Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis Am J Surg Pathol 20 1996 277 285
4. H.J. Norris, E. Roth, and H.B. Taylor Mesenchymal tumors of the uterus II. A clinical and pathologic study of 31 mixed mesodermal tumors Obstet Gynecol 28 1966 57 63
5. H.J. Norris, and H.B. Taylor Mesenchymal tumors of the uterus III. A clinical and pathologic study of 31 carcinosarcomas Cancer 19 1966 1459 1465
6. S.E. Ferguson, C. Tornos, A. Hummer, R.R. Barakat, and R.A. Soslow Prognostic features of surgical stage I uterine carcinosarcoma Am J Surg Pathol 31 2007 1653 1661
7. M.A. Macasaet, M. Waxman, and R.G. Fruchter Prognostic factors in malignant mesodermal (Müllerian) mixed tumors of the uterus Gynecol Oncol 20 1985 32 42
8. E. George, J.C. Manivel, L.P. Dehner, and M.R. Wick Malignant mixed Müllerian tumors: an immunohistochemical study of 47 cases, with histogenetic considerations and clinical correlation Hum Pathol 22 1991 215 223
9. Y. Iwasa, H. Haga, and I. Konishi Prognostic factors in uterine carcinosarcoma: a clinicopathologic study of 25 patients Cancer 82 1998 512 519
10. B. de Crombrugghe, V. Lefebvre, R.R. Behringer, W. Bi, S. Murakami, and W. Huang Transcriptional mechanisms of chondrocyte differentiation Matrix Biol 19 2000 389 394
11. R.A. Kosher, W.M. Kulyk, and S.W. Gay Collagen gene expression during limb bud differentiation J Cell Biol 102 1986 1151 1156
12. K.S. Cheah, E.T. Lau, P.K. Au, and P.P. Tam Expression of the mouse alpha 1 (II) collagen gene is not restricted to cartilage during development Development 111 1991 945 953
13. L.J. Ng, P.P.L. Tam, and K.S.E. Cheah Preferential expression of alternatively spliced mRNAs encoding type II procollagen with a cysteine-rich amino-propeptide in differentiating cartilage and nonchondrogenic tissues during early mouse development Dev Biol 159 1993 403 417
14. V.C.H. Lui, L.J. Ng, J. Nicholls, P.P.L. Tam, and K.S.E. Cheah Tissue-specific and differential expression of alternatively spliced α1 (II) collagen mRNAs in early human embryos Dev Dyn 203 1995 198 211
15. T. Aigner, S. Dertinger, J. Belke, and T. Kirchner Chondrocytic differentiation in clear cell chondrosarcoma Hum Pathol 27 1996 1301 1305
16. T. Aigner, S. Dertinger, S.I. Voronezh, J. Duchies, K. von der Mark, and T. Kirchner Phenotypic diversity of neoplastic chondrocytes and extracellular matrix gene expression in cartilaginous neoplasms Am J Pathol 150 1997 2133 2141
17. D.M. Bell, K.K.H. Leung, and S.C. Wheatley Sox9 directly regulates the type-II collagen gene Nat Genet 16 1997 174 178
18. V. Lefebvre, P. Li, and B. de Crombrugghe A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are expressed in chondrogenesis and cooperatively activate the type II collagen gene EMBO J 17 1998 5718 5733
19. M. Suita, T. Saito, and T. Ikeda Transcriptional induction of Sox9 by NF-κB family member Relax in chondrogenic cells Osteoarthritis Cartilage 17 2009 1065 1075
20. D. Ikegami, H. Akiyama, and A. Suzuki Sox9 sustains chondrocyte survival and hypertrophy in part through PIK3CA-Akt pathways Development 138 2011 1507 1519
21. WAF1 pathway Am J Pathol 181 2012 684 692
22. S.G. Silverberg, G.L. Mutter, R.J. Kurman, R.A. Kubik-Huch, F. Nogates, and F.A. Tavassoli Tumours of the uterine corpus. Epithelial tumours and related lesions F.A. Tavassoli, World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs 2003 IARC Press Lyon, France 221 232
23. M. Saegusa, M. Hashimura, and T. Kuwata Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas Lab Invest 92 2012 511 521
24. M. Saegusa, M. Hashimura, T. Kuwata, M. Hamano, Y. Wani, and I. Okayasu A functional role of Cdx2 in β-catenin signaling during transdifferentiation in endometrial carcinomas Carcinogenesis 28 2007 1885 1892
25. K.K.H. Leung, L.J. Ng, K.K.Y. Ho, P.P.L. Tam, and K.S.E. Cheah Different cis-regulatory DNA elements mediate developmental stage- and tissue-specific expression of the human COL2A1 gene in transgenic mice J Cell Biol 141 1998 1291 1300
26. V. Lefebvre, W. Huang, V.R. Harley, P.N. Goodfellow, and B. de Crombrugghe Sox9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene Mol Cell Biol 17 1997 2336 2346