Interleukin 13 and Serotonin: Linking the Immune and Endocrine Systems in Murine Models of Intestinal Inflammation

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Shajib, Md Sharif ^a,b   Wang, Huaqing ^a,b   Kim, Janice J ^a,b   Sunjic, Ivana ^a,b   Ghia, Jean Eric ^c   Denou, Emmanuel ^b   Collins, Matthew ^a,b   Denburg, Judah A ^b   Khan, Waliul I ^a,b,d  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

^d HAMILTON REGIONAL LABORATORY MEDICINE PROGRAM   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE DERIVATIVE; DEXTRAN SULFATE; DINITROBENZENESULFONIC ACID; INTERLEUKIN 13; RECOMBINANT INTERLEUKIN 13; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL INFILTRATION; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; DISEASE MODEL; DISEASE SEVERITY; DOWN REGULATION; ENDOCRINE SYSTEM; ENTEROCHROMAFFIN CELL; HISTOPATHOLOGY; IMMUNE SYSTEM; MACROPHAGE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; BENZENESULFONATES; COLITIS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; ENDOCRINE SYSTEM; INTERLEUKIN-13; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; SEROTONIN;

EID: 84883433291     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072774     Document Type: Article

References (34)

1. Khan WI, Motomura Y, Wang H, El-Sharkawy RT, Verdu EF, et al. (2006) Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 291: G803.
2. Bamias G, Kaltsa G, Ladas SD, (2011) Cytokines in the pathogenesis of ulcerative colitis. Discov Med 11: 459-467.
3. Strober W, Fuss IJ, (2011) Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140 1756-1767: e1.
4. Heller F, Florian P, Bojarski C, Richter J, Christ M, et al. (2005) Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 129: 550-564.
5. Fuss IJ, Heller F, Boirivant M, Leon F, Yoshida M, et al. (2004) Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 113: 1490-1497.
6. Mannon PJ, Hornung RL, Yang Z, Yi C, Groden C, et al. (2011) Suppression of inflammation in ulcerative colitis by interferon-β-1a is accompanied by inhibition of IL-13 production. Gut 60: 449.
7. Boirivant M, Fuss IJ, Chu A, Strober W, (1998) Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 188: 1929.
8. Heller F, Fuss IJ, Nieuwenhuis EE, Blumberg RS, Strober W, (2002) Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 17: 629-638.
9. Miller LJ (1999) Gastrointestinal hormones and receptors. In: Yamada T, Alpers DH, Laine L, Owyang C, Powell DW, editors. Textbook of Gastroentorology (3rd ed.) Philadelphia: Lippincott-Williams and Wilkins. 35-66.
10. Ghia JE, Li N, Wang H, Collins M, Deng Y, et al. (2009) Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology 137: 1649-1660 10.1053/j.gastro.2009.08.041.
11. Khan WI, Ghia JE, (2010) Gut hormones: Emerging role in immune activation and inflammation. Clinical & Experimental Immunology 161: 19-27.
12. Oshima S, Fujimura M, Fukimiya M, (1999) Changes in number of serotonin-containing cells and serotonin levels in the intestinal mucosa of rats with colitis induced by dextran sodium sulfate. Histochem Cell Biol 112: 257-263.
13. Linden DR, Chen JX, Gershon MD, Sharkey KA, Mawe GM, (2003) Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 285: G207.
14. Yang GB, Lackner AA, (2004) Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity. J Neuroimmunol 146: 46-49.
15. Motomura Y, Ghia JE, Wang H, Akiho H, El-Sharkawy RT, et al. (2008) Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments. Gut 57: 475.
16. Wang H, Steeds J, Motomura Y, Deng Y, Verma-Gandhu M, et al. (2007) CD4 T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection. Gut 56: 949.
17. Manocha MM, Shajib MS, Rahman MM, Wang H, Rengasamy P, et al. (2012) IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut. Mucosal Immunology 6: 146-55.
18. Kim JJ, Bridle BW, Ghia JE, Wang H, Syed SN, et al. (2013) Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. The Journal of Immunology 190: 4795-4804.
19. McKenzie GJ, Bancroft A, Grencis RK, McKenzie ANJ, (1998) A distinct role for interleukin-13 in Th2-cell-mediated immune responses. Current Biology 8: 339-342.
20. Cooper HS, Murthy SN, Shah RS, Sedergran DJ, (1993) Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69: 238-249.
21. Khan WI, Blennerhasset P, Varghese A, Chowdhury S, Omsted P, et al. (2002) Intestinal nematode infection ameliorates experimental colitis in mice. Infect Immun 70: 5931-5937.
22. Kim JJ, Shajib MS, Manocha MM, Khan WI, (2012) Investigating intestinal inflammation in DSS-induced model of IBD. Journal of Visualized Experiments 60: e3678.
23. Matos I, Bento AF, Marcon R, Claudino RF, Calixto JB, (2013) Preventive and therapeutic oral administration of the pentacyclic triterpene alpha,beta-amyrin ameliorates dextran sulfate sodium-induced colitis in mice: The relevance of cannabinoid system. Mol Immunol 54: 482-492.
24. Loftus EV, (2004) Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology 126: 1504-1517.
25. Thoreson R, Cullen JJ, (2007) Pathophysiology of inflammatory bowel disease: An overview. Surg Clin North Am 87: 575-585.
26. Wynn TA, (2003) IL-13 effector functions. Annu Rev Immunol 21: 425-456.
27. Mentink-Kane MM, Wynn TA, (2004) Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease. Immunol Rev 202: 191-202.
28. Kiser D, Steemer S B, Branchi I, Homberg JR, (2011) The reciprocal interaction between serotonin and social behaviour. Neuroscience & Biobehavioral Reviews 36: 786-98.
29. Nelson DL, Gehlert DR, (2006) Central nervous system biogenic amine targets for control of appetite and energy expenditure. Endocrine 29: 49-60.
30. Li N, Ghia JE, Wang H, McClemens J, Cote F, et al. (2011) Serotonin activates dendritic cell function in the context of gut inflammation. The American Journal of Pathology 178: 662-671.
31. Wirtz S, Neufert C, Weigmann B, Neurath MF, (2007) Chemically induced mouse models of intestinal inflammation. Nature Protocols 2: 541-546.
32. Qiu B, Vallance B, Blennerhassett P, Collins S, (1999) The role of CD4 lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis. Nat Med 5: 1178-1182.
33. Fuss I, Strober W, (2008) The role of IL-13 and NK T cells in experimental and human ulcerative colitis. Mucosal immunology 1: S31-S33.
34. Manocha MM, Khan WI, (2012) Serotonin and GI disorders: An update on clinical and experimental studies. Clinical and Translational Gastroenterology 3: e13.