Changing the fate of cancer, one splice at a time

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 36, 2013, Pages 14510-14511

  Schonberg, David L ^a   Venere, Monica ^a   Rich, Jeremy N ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RETINOIC ACID;

BRAIN TUMOR; CANCER STEM CELL; CARCINOGENESIS; CELL DIFFERENTIATION; EXON; GLIOBLASTOMA; NEOPLASM; NERVE CELL DIFFERENTIATION; NONHUMAN; NOTE; PRIORITY JOURNAL; RNA SPLICING; ANIMAL; FEMALE; GENETICS; HUMAN;

ANIMALS; BRAIN NEOPLASMS; CARCINOGENESIS; CELL DIFFERENTIATION; FEMALE; GLIOBLASTOMA; HUMANS;

EID: 84883415418     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1313419110     Document Type: Note

References (17)

1. Venere M, Fine HA, Dirks PB, Rich JN (2011) Cancer stem cells in gliomas: Identifying and understanding the apex cell in cancer's hierarchy. Glia 59(8):1148-1154.
2. Schonberg DL, Lubelski D, Miller TE, Rich JN (2013) Brain tumor stem cells: Molecular characteristics and their impact on therapy. Mol Aspects Med, 10.1016/j.mam.2013.06.004.
3. van Es JH, et al. (2012) Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol 14(10):1099-1104, 10.1038/ncb2581.
4. Friedmann-Morvinski D, et al. (2012) Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science 338(6110):1080-1084.
5. Bachoo RM, et al. (2002) Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 1(3):269-277. (Pubitemid 41039151)
6. Wang R, et al. (2010) Glioblastoma stem-like cells give rise to tumour endothelium. Nature 468(7325):829-833.
7. Cheng L, et al. (2013) Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell 153(1):139-152.
8. Hu J, et al. (2013) Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci USA 110:14520-14527.
9. Levin VA, et al. (2006) Combination chemotherapy with 13-cisretinoic acid and celecoxib in the treatment of glioblastoma multiforme. J Neurooncol 78(1):85-90. (Pubitemid 43786665)
10. Piccirillo SG, et al. (2006) Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444(7120):761-765. (Pubitemid 44949605)
11. Svechnikova I, Almqvist PM, Ekström TJ (2008) HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin. Int J Oncol 32(4):821-827. (Pubitemid 351780592)
12. Sun P, et al. (2009) DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells 27(7):1473-1486.
13. Fogel BL, et al. (2012) RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. Hum Mol Genet 21(19):4171-4186.
14. Yeo GW, et al. (2009) An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol 16(2):130-137.
15. Gehman LT, et al. (2011) The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet 43(7):706-711.
16. Muth-Köhne E, Pachernegg S, Karus M, Faissner A, Hollmann M (2010) Expression of NMDA receptors and Ca2+-impermeable AMPA receptors requires neuronal differentiation and allows discrimination between two different types of neural stem cells. Cell Physiol Biochem 26(6):935-946.
17. Markert JM, et al. (2001) Differential gene expression profiling in human brain tumors. Physiol Genomics 5(1):21-33. (Pubitemid 33675199)