Biochemical Competition Makes Fatty-Acid β-Oxidation Vulnerable to Substrate Overload

PLoS Computational Biology

Volumn 9, Issue 8, 2013, Pages

  van Eunen, Karen ^a,b   Simons, Sereh M J ^a   Gerding, Albert ^a   Bleeker, Aycha ^a   den Besten, Gijs ^a,b   Touw, Catharina M L ^a   Houten, Sander M ^c   Groen, Bert K ^a,b   Krab, Klaas ^d   Reijngoud, Dirk Jan ^a,b   Bakker, Barbara M ^a,b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Netherlands Consortium for Systems Biology   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; FATTY ACIDS; INTEGRAL EQUATIONS; METABOLISM; MITOCHONDRIA; RATS;

CARNITINE; COMPUTATIONAL MODELLING; ENZYMES KINETICS; FATTY ACID METABOLISM; KINETIC EQUATIONS; METABOLIC DISEASE; NETWORK DYNAMICS; OVERLOAD CONDITION; RAT LIVER ENZYMES; RAT LIVER MITOCHONDRIA;

OXIDATION;

ACYL COENZYME A; ACYL COENZYME A DEHYDROGENASE; LIVER ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE; PALMITOYL COENZYME A HYDROLASE; PALMITOYLCARNITINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; BIOCHEMISTRY; CELL ISOLATION; ENZYME DEFICIENCY; ENZYME KINETICS; ENZYME SPECIFICITY; FATTY ACID OXIDATION; LIVER MITOCHONDRION; METABOLIC PARAMETERS; METABOLITE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PREDICTION; RAT; VALIDATION PROCESS;

RATTUS;

EID: 84883408636     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003186     Document Type: Article

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