Engineering strategies for enhancing the production of eicosapentaenoic acid (EPA) from an isolated microalga Nannochloropsis oceanica CY2

Bioresource Technology

Volumn 147, Issue , 2013, Pages 160-167

  Chen, Chun Yen ^a   Chen, Yu Chun ^a   Huang, Hsiao Chen ^a   Huang, Chieh Chen ^b   Lee, Wen Lung ^c   Chang, Jo Shu ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c DEPARTMENT OF ELECTRONIC ENGINEERING   (Taiwan)

Author keywords

Eicosapentaenoic acid (EPA); LED; Microalgae; Nannochloropsis oceanic; Photobioreactor

Indexed keywords

BATCH CELL CULTURE; CELL ENGINEERING; LIGHT EMITTING DIODES; MICROORGANISMS; UNSATURATED FATTY ACIDS;

BIOMASS CONCENTRATIONS; EICOSAPENTAENOIC ACID; HIGHLY UNSATURATED FATTY ACIDS; MICRO-ALGAE; MICROALGAL CULTURES; NANNOCHLOROPSIS OCEANIC; PHOTOBIORE-ACTOR; SEMI-BATCH CULTURES;

ALGAE;

FATTY ACID; ICOSAPENTAENOIC ACID; NITROGEN; PHOSPHATE; TRACE METAL;

BIOMASS; CONCENTRATION (COMPOSITION); FATTY ACID; GROWTH RATE; MICROALGA;

ABSORPTION SPECTROSCOPY; ARTICLE; BACTERIUM CULTURE; BIOENGINEERING; BIOMASS; BIOMASS PRODUCTION; BIOSYNTHESIS; CELL COMPOSITION; CELL GROWTH; CELL MEMBRANE; CHLOROPLAST; ELECTRON TRANSPORT; ENDOPLASMIC RETICULUM; ILLUMINATION; MICROALGA; NANNOCHLOROPSIS OCEANICA; NONHUMAN; PHOTOBIOREACTOR; PHOTOSYNTHESIS; PRIORITY JOURNAL;

NANNOCHLOROPSIS; NANNOCHLOROPSIS OCEANICA;

EICOSAPENTAENOIC ACID (EPA); LED; MICROALGAE; NANNOCHLOROPSIS OCEANIC; PHOTOBIOREACTOR;

BIOMASS; BIOREACTORS; EICOSAPENTAENOIC ACID; MICROALGAE;

EID: 84883388856     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2013.08.051     Document Type: Article

References (31)

1. Carvalho A.P., Pontes I., Gaspar H., Malcata F.X. Metabolic relationships between macro- and micronutrients, and the eicosapentaenoic acid and docosahexaenoic acid contents of Pavlova lutheri. Enzyme Microb. Technol. 2006, 38(3-4):358-366.
2. Carvalho A.P., Silva S.O., Baptista J.M., Malcata F.X. Light requirements in microalgal photobioreactors: an overview of biophotonic aspects. Appl. Microbiol. Biotechnol. 2011, 89(5):1275-1288.
3. Chen C.Y., Yeh K.L., Su H.M., Lo Y.C., Chen W.M., Chang J.S. Strategies to enhance cell growth and achieve high-level oil production of aChlorella vulgaris isolate. Biotechnol. Prog. 2010, 26(3):679-686.
4. Chen C.-Y., Liu C.-H., Lo Y.-C., Chang J.-S. Perspectives on cultivation strategies and photobioreactor designs for photo-fermentative hydrogen production. Bioresour. Technol. 2011, 102(18):8484-8492.
5. Chiu S.-Y., Kao C.-Y., Tsai M.-T., Ong S.-C., Chen C.-H., Lin C.-S. Lipid accumulation and CO(2) utilization of Nannochloropsis oculata in response to CO(2) aeration. Bioresour. Technol. 2009, 100(2):833-838.
6. Das P., Lei W., Aziz S.S., Obbard J.P. Enhanced algae growth in both phototrophic and mixotrophic culture under blue light. Bioresour. Technol. 2011, 102(4):3883-3887.
7. Fang X., Wei C., Cai Z.L., Fan O. Effects of organic carbon sources on cell growth and eicosapentaenoic acid content of Nannochloropsis sp. J. Appl. Phycol. 2004, 16(6):499-503.
8. Fu W.Q., Guomundsson O., Paglia G., Herjolfsson G., Andresson O.S., Palsson B.O., Brynjolfsson S. Enhancement of carotenoid biosynthesis in the green microalgaDunaliella salina with light-emitting diodes and adaptive laboratory evolution. Appl. Microbiol. Biotechnol. 2013, 97(6):2395-2403.
9. Hansen P.J. Effect of high pH on the growth and survival of marine phytoplankton: implications for species succession. Aquat. Microb. Ecol. 2002, 28(3):279-288.
10. 2-emission mitigation systems-a review. Biotechnol. Adv. 2011, 29(2):189-198.
11. Hoffmann M., Marxen K., Schulz R., Vanselow K.H. TFA and EPA productivities of Nannochloropsis salina influenced by temperature and nitrate stimuli in turbidostatic controlled experiments. Mar. Drugs 2010, 8(9):2526-2545.
12. 2 concentrations. J. Appl. Phycol. 2005, 17(1):29-34.
13. 2 concentration. Biotechnol. Lett. 2006, 28(13):987-992.
14. Hu Q., Sommerfeld M., Jarvis E., Ghirardi M., Posewitz M., Seibert M., Darzins A. Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances. Plant J. 2008, 54(4):621-639.
15. Korbee N., Figueroa F.L., Aguilera J. Effect of light quality on the accumulation of photosynthetic pigments, proteins and mycosporine-like amino acids in the red alga Porphyra leucosticta (Bangiales, Rhodophyta). J. Photochem. Photobiol. B 2005, 80(2):71-78.
16. Kromkamp J.C., Beardall J., Sukenik A., Kopecky J., Masojidek J., van Bergeijk S., Gabai S., Shaham E., Yamshon A. Short-term variations in photosynthetic parameters of Nannochloropsis cultures grown in two types of outdoor mass cultivation systems. Aquat. Microb. Ecol. 2009, 56(2-3):309-322.
17. Lee C.G., Palsson B.O. Light-emitting diode-based algal photobioreactor with external gas-exchange. J. Ferment. Bioeng. 1995, 79(3):257-263.
18. Li Y.Q., Horsman M., Wang B., Wu N., Lan C.Q. Effects of nitrogen sources on cell growth and lipid accumulation of green alga Neochloris oleoabundans. Appl. Microbiol. Biotechnol. 2008, 81(4):629-636.
19. Packer M. Algal capture of carbon dioxide; biomass generation as a tool for greenhouse gas mitigation with reference to New Zealand energy strategy and policy. Energ Policy 2009, 37(9):3428-3437.
20. Pal D., Khozin-Goldberg I., Cohen Z., Boussiba S. The effect of light, salinity, and nitrogen availability on lipid production byNannochloropsis sp. Appl. Microbiol. Biotechnol. 2011, 90(4):1429-1441.
21. Radakovits R., Jinkerson R.E., Darzins A., Posewitz M.C. Genetic engineering of algae for enhanced biofuel production. Eukaryot. Cell 2010, 9(4):486-501.
22. Ruxton C.H.S., Calder P.C., Reed S.C., Simpson M.J.A. The impact of long-chain n-3 polyunsaturated fatty acids on human health. Nutr. Res. Rev. 2005, 18(1):113-129.
23. Shu C.H., Tsai C.C., Liao W.H., Chen K.Y., Huang H.C. Effects of light quality on the accumulation of oil in a mixed culture of Chlorella sp. andSaccharomyces cerevisiae. J. Chem. Technol. Biotechnol. 2012, 87(5):601-607.
24. Skerratt J.H., Davidson A.D., Nichols P.D., McMeekin T.A. Effect of UV-B on lipid content of three Antarctic marine phytoplankton. Phytochemistry 1998, 49(4):999-1007.
25. Su C.H., Giridhar R., Chen C.W., Wu W.T. A novel approach for medium formulation for growth of a microalga using motile intensity. Bioresour. Technol. 2007, 98(16):3012-3016.
26. Sukenik A. Ecophysiological considerations in the optimization of eicosapentaenoic acid production by Nannochloropsis-sp. (Eustigmatophyceae). Bioresour. Technol. 1991, 35(3):263-269.
27. Sukenik A., Carmeli Y. Lipid-synthesis and fatty-acid composition in Nannochloropsis sp. (Eustigmatophyceae) grown in a light-dark cycle. J. Phycol. 1990, 26(3):463-469.
28. Sukenik A., Takahashi H., Mokady S. Dietary lipids from marine unicellular algae enhance the amount of liver and blood omega-3-fatty-acids in rats. Ann. Nutr. Metab. 1994, 38(2):85-96.
29. Sukenik A., Beardall J., Kromkamp J.C., Kopecky J., Masojidek J., van Bergeijk S., Gabai S., Shaham E., Yamshon A. Photosynthetic performance of outdoorNannochloropsis mass cultures under a wide range of environmental conditions. Aquat. Microb. Ecol. 2009, 56(2-3):297-308.
30. Xu F., Cai Z.L., Cong W., Fan O.Y. Growth and fatty acid composition of Nannochloropsis sp. grown mixotrophically in fed-batch culture. Biotechnol. Lett. 2004, 26(17):1319-1322.
31. Yeh K.L., Chang J.S. Effects of cultivation conditions and media composition on cell growth and lipid productivity of indigenous microalgaChlorella vulgaris ESP-31. Bioresour. Technol. 2012, 105:120-127.