FcγR-driven release of IL-6 by macrophages requires NOX2-dependent production of reactive oxygen species

Journal of Biological Chemistry

Volumn 288, Issue 35, 2013, Pages 25098-25108

  Franchini, Anthony M ^a   Hunt, Danielle ^a   Melendez, J Andres ^b   Drake, James R ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT ACTIVATION; IMMUNE COMPLEX; REACTIVE OXYGEN SPECIES; SECOND MESSENGER;

ACTIVATION ANALYSIS;

SIGNAL TRANSDUCTION;

CATALASE; FC RECEPTOR; HYDROGEN PEROXIDE; INTERLEUKIN 6; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; FRANCISELLA TULARENSIS; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DEPLETION; SIGNAL TRANSDUCTION;

AKT; FC RECEPTORS; FRANCISELLA TULARENSIS; MACROPHAGES; NADPH OXIDASE; REACTIVE OXYGEN SPECIES (ROS);

ANIMALS; BACTERIAL PROTEINS; BONE MARROW CELLS; CATALASE; FRANCISELLA TULARENSIS; HYDROGEN PEROXIDE; IMMUNITY, INNATE; INTERLEUKIN-6; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; NADPH OXIDASE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, IGG; SIGNAL TRANSDUCTION;

EID: 84883370179     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.474106     Document Type: Article

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