-
1
-
-
82255161944
-
Road to ruin: Targeting proteins for degradation in the endoplasmic reticulum
-
Smith, M. H., Ploegh, H. L., and Weissman, J. S. (2011) Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science 334, 1086-1090
-
(2011)
Science
, vol.334
, pp. 1086-1090
-
-
Smith, M.H.1
Ploegh, H.L.2
Weissman, J.S.3
-
2
-
-
75649114551
-
Mechanism and components of endoplasmic reticulum-associated degradation
-
Hoseki, J., Ushioda, R., and Nagata, K. (2010) Mechanism and components of endoplasmic reticulum-associated degradation. J. Biochem. 147, 19-25
-
(2010)
J. Biochem
, vol.147
, pp. 19-25
-
-
Hoseki, J.1
Ushioda, R.2
Nagata, K.3
-
3
-
-
78149482323
-
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p
-
Carvalho, P., Stanley, A. M., and Rapoport, T. A. (2010) Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell 143, 579-591
-
(2010)
Cell
, vol.143
, pp. 579-591
-
-
Carvalho, P.1
Stanley, A.M.2
Rapoport, T.A.3
-
4
-
-
3042677637
-
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
-
Ye, Y., Shibata, Y., Yun, C., Ron, D., and Rapoport, T. A. (2004) A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 429, 841-847
-
(2004)
Nature
, vol.429
, pp. 841-847
-
-
Ye, Y.1
Shibata, Y.2
Yun, C.3
Ron, D.4
Rapoport, T.A.5
-
5
-
-
3042616595
-
A membrane protein required for dislocation of misfolded proteins from the ER
-
Lilley, B. N., and Ploegh, H. L. (2004) A membrane protein required for dislocation of misfolded proteins from the ER. Nature 429, 834-840
-
(2004)
Nature
, vol.429
, pp. 834-840
-
-
Lilley, B.N.1
Ploegh, H.L.2
-
6
-
-
0141592584
-
Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD
-
Taxis, C., Hitt, R., Park, S. H., Deak, P. M., Kostova, Z., and Wolf, D. H. (2003) Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. J. Biol. Chem. 278, 35903-35913
-
(2003)
J. Biol. Chem
, vol.278
, pp. 35903-35913
-
-
Taxis, C.1
Hitt, R.2
Park, S.H.3
Deak, P.M.4
Kostova, Z.5
Wolf, D.H.6
-
7
-
-
77949312283
-
Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase
-
Carroll, S. M., and Hampton, R. Y. (2010) Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. J. Biol. Chem. 285, 5146-5156
-
(2010)
J. Biol. Chem
, vol.285
, pp. 5146-5156
-
-
Carroll, S.M.1
Hampton, R.Y.2
-
8
-
-
2442451126
-
Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control
-
Vashist, S., and Ng, D. T. (2004) Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control. J. Cell Biol. 165, 41-52
-
(2004)
J. Cell Biol
, vol.165
, pp. 41-52
-
-
Vashist, S.1
Ng, D.T.2
-
9
-
-
33751560802
-
Yeast derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis
-
Sato, B. K., and Hampton, R. Y. (2006) Yeast derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis. Yeast 23, 1053-1064
-
(2006)
Yeast
, vol.23
, pp. 1053-1064
-
-
Sato, B.K.1
Hampton, R.Y.2
-
10
-
-
33746228127
-
Distinct ubiquitinligase complexes define convergent pathways for the degradation of ER proteins
-
Carvalho, P., Goder, V., and Rapoport, T. A. (2006) Distinct ubiquitinligase complexes define convergent pathways for the degradation of ER proteins. Cell 126, 361-373
-
(2006)
Cell
, vol.126
, pp. 361-373
-
-
Carvalho, P.1
Goder, V.2
Rapoport, T.A.3
-
11
-
-
71149100878
-
Usa1 functions as a scaffold of the HRD-ubiquitin ligase
-
Horn, S. C., Hanna, J., Hirsch, C., Volkwein, C., Schütz, A., Heinemann, U., Sommer, T., and Jarosch, E. (2009) Usa1 functions as a scaffold of the HRD-ubiquitin ligase. Mol. Cell 36, 782-793
-
(2009)
Mol. Cell
, vol.36
, pp. 782-793
-
-
Horn, S.C.1
Hanna, J.2
Hirsch, C.3
Volkwein, C.4
Schütz, A.5
Heinemann, U.6
Sommer, T.7
Jarosch, E.8
-
12
-
-
79955611686
-
Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocross-linking
-
Stanley, A. M., Carvalho, P., and Rapoport, T. (2011) Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocross-linking. FEBS Lett. 585, 1281-1286
-
(2011)
FEBS Lett
, vol.585
, pp. 1281-1286
-
-
Stanley, A.M.1
Carvalho, P.2
Rapoport, T.3
-
13
-
-
1842850700
-
Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: Topology and Der1-like proteins
-
Hitt, R., and Wolf, D. H. (2004) Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins. FEMS Yeast Res. 4, 721-729
-
(2004)
FEMS Yeast Res
, vol.4
, pp. 721-729
-
-
Hitt, R.1
Wolf, D.H.2
-
14
-
-
75649144790
-
The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation
-
Bernardi, K. M., Williams, J. M., Kikkert, M., van Voorden, S., Wiertz, E. J., Ye, Y., and Tsai, B. (2010) The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation. Mol. Biol. Cell 21, 140-151
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 140-151
-
-
Bernardi, K.M.1
Williams, J.M.2
Kikkert, M.3
Van Voorden, S.4
Wiertz, E.J.5
Ye, Y.6
Tsai, B.7
-
15
-
-
31944450850
-
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation
-
Oda, Y., Okada, T., Yoshida, H., Kaufman, R. J., Nagata, K., and Mori, K. (2006) Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. J. Cell Biol. 172, 383-393
-
(2006)
J. Cell Biol
, vol.172
, pp. 383-393
-
-
Oda, Y.1
Okada, T.2
Yoshida, H.3
Kaufman, R.J.4
Nagata, K.5
Mori, K.6
-
16
-
-
26244431960
-
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane
-
Lilley, B. N., and Ploegh, H. L. (2005) Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proc. Natl. Acad. Sci. U.S.A. 102, 14296-14301
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 14296-14301
-
-
Lilley, B.N.1
Ploegh, H.L.2
-
17
-
-
26444621357
-
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane
-
Ye, Y., Shibata, Y., Kikkert, M., van Voorden, S., Wiertz, E., and Rapoport, T. A. (2005) Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc. Natl. Acad. Sci. U.S.A. 102, 14132-14138
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 14132-14138
-
-
Ye, Y.1
Shibata, Y.2
Kikkert, M.3
Van Voorden, S.4
Wiertz, E.5
Rapoport, T.A.6
-
18
-
-
84255169603
-
Defining human ERAD networks through an integrative mapping strategy
-
Christianson, J. C., Olzmann, J. A., Shaler, T. A., Sowa, M. E., Bennett, E. J., Richter, C. M., Tyler, R. E., Greenblatt, E. J., Harper, J. W., and Kopito, R. R. (2012) Defining human ERAD networks through an integrative mapping strategy. Nat. Cell Biol. 14, 93-105
-
(2012)
Nat. Cell Biol
, vol.14
, pp. 93-105
-
-
Christianson, J.C.1
Olzmann, J.A.2
Shaler, T.A.3
Sowa, M.E.4
Bennett, E.J.5
Richter, C.M.6
Tyler, R.E.7
Greenblatt, E.J.8
Harper, J.W.9
Kopito, R.R.10
-
19
-
-
79952433637
-
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
-
Chen, X., Tukachinsky, H., Huang, C. H., Jao, C., Chu, Y. R., Tang, H. Y., Mueller, B., Schulman, S., Rapoport, T. A., and Salic, A. (2011) Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J. Cell Biol. 192, 825-838
-
(2011)
J. Cell Biol
, vol.192
, pp. 825-838
-
-
Chen, X.1
Tukachinsky, H.2
Huang, C.H.3
Jao, C.4
Chu, Y.R.5
Tang, H.Y.6
Mueller, B.7
Schulman, S.8
Rapoport, T.A.9
Salic, A.10
-
20
-
-
40249088336
-
OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD
-
Christianson, J. C., Shaler, T. A., Tyler, R. E., and Kopito, R. R. (2008) OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat. Cell Biol. 10, 272-282
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 272-282
-
-
Christianson, J.C.1
Shaler, T.A.2
Tyler, R.E.3
Kopito, R.R.4
-
21
-
-
66449136067
-
EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex
-
Cormier, J. H., Tamura, T., Sunryd, J. C., and Hebert, D. N. (2009) EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. Mol. Cell 34, 627-633
-
(2009)
Mol. Cell
, vol.34
, pp. 627-633
-
-
Cormier, J.H.1
Tamura, T.2
Sunryd, J.C.3
Hebert, D.N.4
-
22
-
-
50449107542
-
SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins
-
Mueller, B., Klemm, E. J., Spooner, E., Claessen, J. H., and Ploegh, H. L. (2008) SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc. Natl. Acad. Sci. U.S.A. 105, 12325-12330
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 12325-12330
-
-
Mueller, B.1
Klemm, E.J.2
Spooner, E.3
Claessen, J.H.4
Ploegh, H.L.5
-
23
-
-
51049121849
-
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP
-
Hosokawa, N., Wada, I., Nagasawa, K., Moriyama, T., Okawa, K., and Nagata, K. (2008) Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. J. Biol. Chem. 283, 20914-20924
-
(2008)
J. Biol. Chem
, vol.283
, pp. 20914-20924
-
-
Hosokawa, N.1
Wada, I.2
Nagasawa, K.3
Moriyama, T.4
Okawa, K.5
Nagata, K.6
-
24
-
-
80455164551
-
Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α1-antitrypsin from the endoplasmic reticulum
-
Greenblatt, E. J., Olzmann, J. A., and Kopito, R. R. (2011) Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α1-antitrypsin from the endoplasmic reticulum. Nat. Struct. Mol. Biol. 18, 1147-1152
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 1147-1152
-
-
Greenblatt, E.J.1
Olzmann, J.A.2
Kopito, R.R.3
-
25
-
-
79955758729
-
SEL1L protein critically determines the stability of the HRD1- SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates
-
Iida, Y., Fujimori, T., Okawa, K., Nagata, K., Wada, I., and Hosokawa, N. (2011) SEL1L protein critically determines the stability of the HRD1- SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates. J. Biol. Chem. 286, 16929-16939
-
(2011)
J. Biol. Chem
, vol.286
, pp. 16929-16939
-
-
Iida, Y.1
Fujimori, T.2
Okawa, K.3
Nagata, K.4
Wada, I.5
Hosokawa, N.6
-
26
-
-
0034597161
-
Endoplasmic reticulum degradation requires lumen to cytosol signaling: Transmembrane control of Hrd1p by Hrd3p
-
Gardner, R. G., Swarbrick, G. M., Bays, N. W., Cronin, S. R., Wilhovsky, S., Seelig, L., Kim, C., and Hampton, R. Y. (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling: transmembrane control of Hrd1p by Hrd3p. J. Cell Biol. 151, 69-82
-
(2000)
J. Cell Biol
, vol.151
, pp. 69-82
-
-
Gardner, R.G.1
Swarbrick, G.M.2
Bays, N.W.3
Cronin, S.R.4
Wilhovsky, S.5
Seelig, L.6
Kim, C.7
Hampton, R.Y.8
-
27
-
-
0033492290
-
Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation
-
Plemper, R. K., Bordallo, J., Deak, P. M., Taxis, C., Hitt, R., and Wolf, D. H. (1999) Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation. J. Cell Sci. 112, 4123-4134
-
(1999)
J. Cell Sci
, vol.112
, pp. 4123-4134
-
-
Plemper, R.K.1
Bordallo, J.2
Deak, P.M.3
Taxis, C.4
Hitt, R.5
Wolf, D.H.6
-
28
-
-
79959347089
-
A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation
-
Wang, Q., Liu, Y., Soetandyo, N., Baek, K., Hegde, R., and Ye, Y. (2011) A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Mol. Cell 42, 758-770
-
(2011)
Mol. Cell
, vol.42
, pp. 758-770
-
-
Wang, Q.1
Liu, Y.2
Soetandyo, N.3
Baek, K.4
Hegde, R.5
Ye, Y.6
-
29
-
-
79953152999
-
Herp regulates Hrd1-mediated ubiquitylation in a ubiquitinlike domain-dependent manner
-
Kny, M., Standera, S., Hartmann-Petersen, R., Kloetzel, P. M., and Seeger, M. (2011) Herp regulates Hrd1-mediated ubiquitylation in a ubiquitinlike domain-dependent manner. J. Biol. Chem. 286, 5151-5156
-
(2011)
J. Biol. Chem
, vol.286
, pp. 5151-5156
-
-
Kny, M.1
Standera, S.2
Hartmann-Petersen, R.3
Kloetzel, P.M.4
Seeger, M.5
-
30
-
-
84859031557
-
Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice
-
Eura, Y., Yanamoto, H., Arai, Y., Okuda, T., Miyata, T., and Kokame, K. (2012) Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. PLoS One 7, e34298
-
(2012)
PLoS One
, vol.7
-
-
Eura, Y.1
Yanamoto, H.2
Arai, Y.3
Okuda, T.4
Miyata, T.5
Kokame, K.6
-
31
-
-
79952273668
-
Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes
-
Dougan, S. K., Hu, C. C., Paquet, M. E., Greenblatt, M. B., Kim, J., Lilley, B. N., Watson, N., and Ploegh, H. L. (2011) Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol. Cell. Biol. 31, 1145-1159
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 1145-1159
-
-
Dougan, S.K.1
Hu, C.C.2
Paquet, M.E.3
Greenblatt, M.B.4
Kim, J.5
Lilley, B.N.6
Watson, N.7
Ploegh, H.L.8
-
32
-
-
69949171887
-
The TRC8 E3 ligase ubiquitinates MHC class i molecules before dislocation from the ER
-
Stagg, H. R., Thomas, M., van den Boomen, D., Wiertz, E. J., Drabkin, H. A., Gemmill, R. M., and Lehner, P. J. (2009) The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER. J. Cell Biol. 186, 685-692
-
(2009)
J. Cell Biol
, vol.186
, pp. 685-692
-
-
Stagg, H.R.1
Thomas, M.2
Van Den Boomen, D.3
Wiertz, E.J.4
Drabkin, H.A.5
Gemmill, R.M.6
Lehner, P.J.7
-
33
-
-
28144436887
-
The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum-associated degradation pathway
-
Schulze, A., Standera, S., Buerger, E., Kikkert, M., van Voorden, S., Wiertz, E., Koning, F., Kloetzel, P. M., and Seeger, M. (2005) The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum-associated degradation pathway. J. Mol. Biol. 354, 1021-1027
-
(2005)
J. Mol. Biol
, vol.354
, pp. 1021-1027
-
-
Schulze, A.1
Standera, S.2
Buerger, E.3
Kikkert, M.4
Van Voorden, S.5
Wiertz, E.6
Koning, F.7
Kloetzel, P.M.8
Seeger, M.9
|