Amino acid substitutions in gyrA and parC are associated with fluoroquinolone resistance in mycoplasma bovis isolates from Japanese dairy calves

Journal of Veterinary Medical Science

Volumn 75, Issue 8, 2013, Pages 1063-1065

  Sato, Toyotaka ^a   Okubo, Torahiko ^a   Usui, Masaru ^a   Higuchi, Hidetoshi ^a   Tamura, Yutaka ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

Author keywords

Calves; Fuoroquinolone resistance; GyrA; Mycoplasma bovis; ParC

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; QUINOLONE DERIVATIVE;

AMINO ACID SUBSTITUTION; ANIMAL; ANIMAL DISEASE; ANTIFUNGAL RESISTANCE; ARTICLE; CATTLE; CATTLE DISEASE; DRUG EFFECT; GENETICS; JAPAN; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MYCOPLASMA BOVIS; MYCOPLASMOSIS;

AMINO ACID SUBSTITUTION; ANIMALS; CATTLE; CATTLE DISEASES; DNA GYRASE; DNA TOPOISOMERASE IV; DRUG RESISTANCE, FUNGAL; FLUOROQUINOLONES; JAPAN; MICROBIAL SENSITIVITY TESTS; MYCOPLASMA BOVIS; MYCOPLASMA INFECTIONS;

EID: 84883349055     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.12-0508     Document Type: Article

References (8)

1. Bébéar, C. M., Renaudin, H., Charron, A., Bové, J. M., Bébéar, C. and Renaudin, J. 1998. Alterations in topoisomerase IV and DNA gyrase in quinolone-resistant mutants of Mycoplasma hominis obtained in vitro. Antimicrob. Agents Chemother. 42: 2304-2311.
2. Clinical and Laboratory Standards Institute. 2008. Performance standards for antimicrobial disk and dilution antimicrobial susceptibility tests for bacteria isolated from animals. Approved standard, 3rd ed. In: CLSI document M31-A3, CLSI, Wayne.
3. Gagea, M. I., Bateman, K. G., van Dreumel, V., McEwen, B. J., Carman, S., Archambault, M., Shanahan, R. A. and Caswell, J. L. 2006. Diseases and pathogens associated with mortality in Ontario beef feedlots. J. Vet. Diagn. Invest. 18: 18-28.
4. Giraud, E., Cloeckaert, A., Baucheron, S., Mouline, C. and Chaslus-Dancla, E. 2003. Fitness cost of fuoroquinolone resistance in Salmonella enterica serovar Typhimurium. J. Med. Microbiol. 52: 697-703.
5. Hannan, P. C. T. 2000. Guidelines and recommendations for antimicrobial minimum inhibitory concentration (MIC) testing against veterinary Mycoplasma species. Vet. Res. 31: 373-395.
6. Lysnyansky, I., Mikula, I., Gerchman, I. and Levisohn, S. 2009. Rapid detection of a point mutation in the parC gene associated with decreased susceptibility to fuoroquinolones in Mycoplasma bovis. Antimicrob. Agents Chemother. 53: 4911-4914.
7. Reinhardt, A. K., Kempf, I., Kobisch, M. and Gautier-Boucha-rdon, A. V. 2002. Fluoroquinolone resistance in Mycoplasma gallisepticum: DNA gyrase as primary target of enrofoxacin and impact of mutations in topoisomerases on resistance level. J. Antimicrob. Chemother. 50: 589-592.
8. Uemura, R., Sueyoshi, M. and Nagatomo, H. 2010. Antimicrobial susceptibilities of four species of Mycoplasma isolated in 2008 and 2009 from cattle in Japan. J. Vet. Med. Sci. 72: 1661-1663.