Implications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal ortholog

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 36, 2013, Pages 14652-14657

  Liszczak, Glen ^a,b   Marmorstein, Ronen ^a,b  

^a WISTAR INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Enzymology; Evolutionary biology; Structural biology; X ray crystallography

Indexed keywords

ACYLTRANSFERASE; BACTERIAL ENZYME; NATA PROTEIN; NATE PROTEIN; UNCLASSIFIED DRUG; ACETYL COENZYME A; ARCHAEAL PROTEIN; PEPTIDE ALPHA N ACETYLTRANSFERASE; PEPTIDE ALPHA N ACETYLTRANSFERASE A; PEPTIDE ALPHA N ACETYLTRANSFERASE E; PROTEIN BINDING;

ACETYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; SULFOLOBUS SOLFATARICUS; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; EUKARYOTIC CELL; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

ARCHAEA; EUKARYOTA; SULFOLOBUS SOLFATARICUS;

ACETYL COENZYME A; ACETYLATION; AMINO ACID SEQUENCE; ARCHAEAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; EUKARYOTIC CELLS; EVOLUTION, MOLECULAR; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; N-TERMINAL ACETYLTRANSFERASE A; N-TERMINAL ACETYLTRANSFERASE E; N-TERMINAL ACETYLTRANSFERASES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SULFOLOBUS SOLFATARICUS;

EID: 84883342432     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1310365110     Document Type: Article

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