Recombinant human histidine triad nucleotide-binding protein 1 attenuates liver fibrosis induced by carbon tetrachloride in rats

Molecular Medicine Reports

Volumn 8, Issue 4, 2013, Pages 1023-1028

  Wu, Fei ^a   Huang, Shaofang ^a   Zhu, Nanlan ^a   Liu, Wei ^a   Zhang, Yanan ^a   He, Yongwen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Histidine triad nucleotide binding protein 1; Liver fibrosis; Recombinant protein; Transforming growing factor ; catenin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; BETA CATENIN; CARBON TETRACHLORIDE; CYCLIN D1; FRAGILE HISTIDINE TRIAD PROTEIN; HISTIDINE TRIAD NUCLEOTIDE BINDING PROTEIN 1; HYDROXYPROLINE; NUCLEOTIDE BINDING PROTEIN; RECOMBINANT PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; HINT1 PROTEIN, HUMAN; MADH3 PROTEIN, RAT; NERVE PROTEIN; SMAD7 PROTEIN, RAT; TGFB1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG PURIFICATION; GENE EXPRESSION; GENE TECHNOLOGY; GENETIC ENGINEERING; HISTOPATHOLOGY; LIVER; LIVER FIBROSIS; MALE; NONHUMAN; PROTEIN ENGINEERING; PROTEIN PURIFICATION; RAT; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; HUMAN; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; STELLATE CELL;

RATTUS;

ANIMALS; CARBON TETRACHLORIDE; HEPATIC STELLATE CELLS; HUMANS; HYDROXYPROLINE; LIVER; LIVER CIRRHOSIS; MALE; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84883336097     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1618     Document Type: Article

References (33)

1. Albanis E and Friedman SL: Hepatic fibrosis: Pathogenesis and principles of therapy. Clin Liver Dis 5: 315-334, 2001.
2. Gutierrez-Reyes G, Gutierrez-Ruiz MC and Kershenobich D: Liver fibrosis and chronic viral hepatitis. Arch Med Res 38: 644-651, 2007.
3. Friedman SL: Liver fibrosis - from bench to bedside. J Hepatol 38: S38-S53, 2003.
4. Parsons CJ, Takashima M and Rippe RA: Molecular mechanisms of hepatic fibrogenesis. J Gastroenterol Hepatol 22: S79-S84, 2007.
5. Gressner AM and Weiskirchen R: Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med 10: 76-99, 2006.
6. Inagaki Y and Okazaki I: Emerging insights into transforming growth factor beta Smad signal in hepatic fibrogenesis. Gut 56: 284-292, 2007.
7. Bataller R and Brenner DA: Liver fibrosis. J Clin Invest 115: 209-218, 2005.
8. Sohrabpour AA, Mohamadnejad M and Malekzadeh R: Review article: the reversibility of cirrhosis. Aliment Pharmacol Ther 36: 824-832, 2012.
9. Varga J and Pasche B: Antitransforming growth factor-beta therapy in fibrosis: recent progress and implications for systemic sclerosis. Curr Opin Rheumatol 20: 720-728, 2008.
10. de Gouville AC, Boullay V, Krysa G, et al: Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis. Br J Pharmacol 145: 166-177, 2005.
11. Clevers H: Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480, 2006.
12. Cheng JH, She HY, Han YP, et al: Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol 294: G39-G49, 2008.
13. Li W, Zhu C, Chen X, Li Y, Gao R and Wu Q: Pokeweed antiviral protein down-regulates Wnt/beta-catenin signalling to attenuate liver fibrogenesis in vitro and in vivo. Dig Liver Dis 43: 559-566, 2011.
14. Thompson MD and Monga SP: WNT/beta-catenin signaling in liver health and disease. Hepatology 45: 1298-1305, 2007.
15. Li WT, He YW, Xiao ZH and Ma YB: Effect of beta-catenin on the activation of hepatic stellate cells induced by transforming growth factor-beta1. Zhonghua Gan Zang Bing Za Zhi 17: 188-192, 2009 (In Chinese).
16. Baarsma HA, Spanjer AI, Haitsma G, et al: Activation of WNT/beta-catenin signaling in pulmonary fibroblasts by TGF-beta1 is increased in chronic obstructive pulmonary disease. PLoS ONE 6: e25450, 2011.
17. Tian X, Zhang J, Tan TK, et al: Association of beta-catenin with P-Smad3 but not LEF-1 differentiates in vitro profibrotic and anti-inflammatory effects of TGF-beta1. J Cell Sci 2012.
18. Li H, Zhang Y, Su T, Santella RM and Weinstein IB: Hint1 is a haplo-insufficient tumor suppressor in mice. Oncogene 25: 713-721, 2006.
19. Weiske J and Huber O: The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity. J Biol Chem 281: 27356-27366, 2006.
20. Huber O and Weiske J: Beta-catenin takes a HIT. Cell Cycle 7: 1326-1331, 2008.
21. Weiske J and Huber O: The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. J Cell Sci 118: 3117-3129, 2005.
22. Genovese G, Ghosh P, Li H, et al: The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells. Cell Cycle 11: 2206-2215, 2012.
23. Wang L, Li H, Zhang Y, Santella RM and Weinstein IB: HINT1 inhibits beta-catenin/TCF4, USF2 and NF?B activity in human hepatoma cells. Int J Cancer 124: 1526-1534, 2009.
24. Yao H, Pan J, Qian Y, et al: Enhanced effect of soluble transforming growth factor-beta receptor II and IFN-gamma fusion protein in reversing hepatic fibrosis. Eur J Med Res 15: 152-161, 2010.
25. Liu T and He YW: Protective effect of recombinant HMGB1 A box protein in mouse with acute hepatic failure. Zhonghua Gan Zang Bing Za Zhi 18: 222-226, 2010 (In Chinese).
26. Schuppan D and Afdhal NH: Liver cirrhosis. Lancet 371: 838-851, 2008
27. Carpino G, Morini S, Ginanni Corradini S, et al: Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation. Dig Liver Dis 37: 349-356, 2005.
28. Safadi R and Friedman SL: Hepatic fibrosis-role of hepatic stellate cell activation. MedGenMed 4: 27, 2002.
29. Shek FW and Benyon RC: How can transforming growth factor beta be targeted usefully to combat liver fibrosis? Eur J Gastroenterol Hepatol 16: 123-126, 2004.
30. Cheon SS, Wei Q, Gurung A, et al: Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J 20: 692-701, 2006.
31. Medici D, Hay ED and Olsen BR: Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. Mol Biol Cell 19: 4875-4887, 2008.
32. Shtutman M, Zhurinsky J, Simcha I, et al: The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Nat Acad Sci USA 96: 5522-5527, 1999.
33. Razin E, Zhang ZC, Nechushtan H, et al: Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells. J Biol Chem 274: 34272-34276, 1999.