Creatine supplementation in fibromyalgia: A randomized, double-blind, placebo-controlled trial

Arthritis Care and Research

Volumn 65, Issue 9, 2013, Pages 1449-1459

  Alves, Christiano R R ^a   Santiago, Bianca M ^a   Lima, Fernanda R ^a   Otaduy, Maria C G ^a   Calich, Ana Luisa ^a   Tritto, Aline C C ^a   De Sá Pinto, Ana Lúcia ^a   Roschel, Hamilton ^a   Leite, Cláudia C ^a   Benatti, Fabiana B ^a   Bonfá, Eloisa ^a   Gualano, Bruno ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE; PLACEBO;

ABSENCE OF SIDE EFFECTS; ADULT; AEROBIC EXERCISE; ARTICLE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FIBROMYALGIA; FOOD INTAKE; HUMAN; ISOMETRIC EXERCISE; KIDNEY FUNCTION; MUSCLE FUNCTION; MUSCLE STRENGTH; PAIN ASSESSMENT; PATIENT COMPLIANCE; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SLEEP QUALITY; TREATMENT OUTCOME;

ADULT; CREATINE; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FIBROMYALGIA; HUMANS; MIDDLE AGED; PHOSPHOCREATINE;

EID: 84883314419     PISSN: 2151464X     EISSN: 21514658     Source Type: Journal    
DOI: 10.1002/acr.22020     Document Type: Article

References (48)

1. Wyss M, Kaddurah-Daouk R,. Creatine and creatinine metabolism. Physiol Rev 2000; 80: 1107-213.
2. Tarnopolsky M, Martin J,. Creatine monohydrate increases strength in patients with neuromuscular disease. Neurology 1999; 52: 854-7.
3. Antolic A, Roy BD, Tarnopolsky MA, Zernicke RF, Wohl GR, Shaughnessy SG, et al. Creatine monohydrate increases bone mineral density in young Sprague-Dawley rats. Med Sci Sports Exerc 2007; 39: 816-20.
4. Neves M Jr, Gualano B, Roschel H, Fuller R, Benatti FB, Pinto AL, et al. Beneficial effect of creatine supplementation in knee osteoarthritis. Med Sci Sports Exerc 2011; 43: 1538-43.
5. NINDS NET-PD Investigators. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology 2006; 66: 664-71.
6. Gualano B, Novaes RB, Artioli GG, Freire TO, Coelho DF, Scagliusi FB, et al. Effects of creatine supplementation on glucose tolerance and insulin sensitivity in sedentary healthy males undergoing aerobic training. Amino Acids 2008; 34: 245-50.
7. Gualano B, DE Salles Painneli V, Roschel H, Artioli GG, Neves M Jr, De Sa Pinto AL, et al. Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Med Sci Sports Exerc 2011; 43: 770-8.
8. Leader A, Amital D, Rubinow A, Amital H,. An open-label study adding creatine monohydrate to ongoing medical regimens in patients with the fibromyalgia syndrome. Ann N Y Acad Sci 2009; 1173: 829-36.
9. Wolfe F, Potter J,. Fibromyalgia and work disability: is fibromyalgia a disabling disorder? Rheum Dis Clin North Am 1996; 22: 369-91.
10. Mease PJ, Choy EH,. Pharmacotherapy of fibromyalgia. Rheum Dis Clin North Am 2009; 35: 359-72.
11. Mease P, Arnold LM, Bennett R, Boonen A, Buskila D, Carville S, et al. Fibromyalgia syndrome. J Rheumatol 2007; 34: 1415-25.
12. Hauser W, Thieme K, Turk DC,. Guidelines on the management of fibromyalgia syndrome: a systematic review. Eur J Pain 2010; 14: 5-10.
13. Bennett R,. The contribution of muscle to the generation of fibromyalgia symptomatology. J Musculoskelet Pain 1996; 4: 35-59.
14. Park JH, Phothimat P, Oates CT, Hernanz-Schulman M, Olsen NJ,. Use of P-31 magnetic resonance spectroscopy to detect metabolic abnormalities in muscles of patients with fibromyalgia. Arthritis Rheum 1998; 41: 406-13.
15. Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L,. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 1995; 38: 19-28.
16. Andres RH, Ducray AD, Schlattner U, Wallimann T, Widmer HR,. Functions and effects of creatine in the central nervous system. Brain Res Bull 2008; 76: 329-43.
17. Coplan JD, Mathew SJ, Mao X, Smith EL, Hof PR, Coplan PM, et al. Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma. Psychiatry Res 2006; 147: 27-39.
18. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the Multicenter Criteria Committee. Arthritis Rheum 1990; 33: 160-72.
19. Roschel H, Neves-Junior M, Gualano B, Barroso R, Robles C, de Sa Pinto AL, et al. Familiarisation with lower limb strength testing in middle-aged women with osteoarthritis of the knee. Physiotherapy 2011; 97: 350-3.
20. Brown L, Weir J,. ASEP procedures recommendation I: accurate assessment of muscular strength and power. J Exerc Physiol Online 2001; 4: 21.
21. Burckhardt CS, Clark SR, Bennett RM,. The Fibromyalgia Impact Questionnaire: development and validation. J Rheumatol 1991; 18: 728-33.
22. Melzack R,. The short-form McGill Pain Questionnaire. Pain 1987; 30: 191-7.
23. Webb WB, Bonnet M, De Jong GD,. A post-sleep inventory. Percept Mot Skills 1976; 43: 987-93.
24. McHorney CA, Ware JE Jr, Raczek AE,. The MOS 36-item Short-Form Health Survey (SF-36). II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care 1993; 31: 247-63.
25. Folstein MF, Folstein SE, McHugh PR,. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-98.
26. Slick DJ, Hopp G, Strauss E, Spellacy FJ,. Victoria Symptom Validity Test: efficiency for detecting feigned memory impairment and relationship to neuropsychological tests and MMPI-2 validity scales. J Clin Exp Neuropsychol 1996; 18: 911-22.
27. Arbuthnott K, Frank J,. Trail making test, part B as a measure of executive control: validation using a set-switching paradigm. J Clin Exp Neuropsychol 2000; 22: 518-28.
28. Cronholm B, Viding G,. Digit span as a test of immediate memory. Nord Med 1956; 56: 1612-4. In Swedish.
29. Nitrini R, Caramelli P, Herrera Junior E, Porto CS, Charchat-Fichman H, Carthery MT, et al. Performance of illiterate and literate nondemented elderly subjects in two tests of long-term memory. J Int Neuropsychol Soc 2004; 10: 634-8.
30. Gotshalk LA, Kraemer WJ, Mendonca MA, Vingren JL, Kenny AM, Spiering BA, et al. Creatine supplementation improves muscular performance in older women. Eur J Appl Physiol 2008; 102: 223-31.
31. Cohen J,. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale (NJ): Lawrence Erlbaum Associates; 1988.
32. Park DC, Glass JM, Minear M, Crofford LJ,. Cognitive function in fibromyalgia patients. Arthritis Rheum 2001; 44: 2125-33.
33. Stockler S, Hanefeld F, Frahm J,. Creatine replacement therapy in guanidinoacetate methyltransferase deficiency, a novel inborn error of metabolism. Lancet 1996; 348: 789-90.
34. Dechent P, Pouwels PJ, Wilken B, Hanefeld F, Frahm J,. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am J Physiol 1999; 277: R698-704.
35. Dechent P, Pouwels PJ, Frahm J,. Neither short-term nor long-term administration of oral choline alters metabolite concentrations in human brain. Biol Psychiatry 1999; 46: 406-11.
36. Rawson ES, Lieberman HR, Walsh TM, Zuber SM, Harhart JM, Matthews TC,. Creatine supplementation does not improve cognitive function in young adults. Physiol Behav 2008; 95: 130-4.
37. Rae C, Digney AL, McEwan SR, Bates TC,. Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. Proc Biol Sci 2003; 270: 2147-50.
38. McMorris T, Mielcarz G, Harris RC, Swain JP, Howard A,. Creatine supplementation and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2007; 14: 517-28.
39. Watanabe A, Kato N, Kato T,. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neurosci Res 2002; 42: 279-85.
40. McMorris T, Harris RC, Howard AN, Langridge G, Hall B, Corbett J, et al. Creatine supplementation, sleep deprivation, cortisol, melatonin and behavior. Physiol Behav 2007; 90: 21-8.
41. Amital D, Fostick L, Polliack ML, Segev S, Zohar J, Rubinow A, et al. Posttraumatic stress disorder, tenderness, and fibromyalgia syndrome: are they different entities? J Psychosom Res 2006; 61: 663-9.
42. Rawson ES, Venezia AC,. Use of creatine in the elderly and evidence for effects on cognitive function in young and old. Amino Acids 2011; 40: 1349-62.
43. Poortmans JR, Francaux M,. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999; 31: 1108-10.
44. Poortmans JR, Kumps A, Duez P, Fofonka A, Carpentier A, Francaux M,. Effect of oral creatine supplementation on urinary methylamine, formaldehyde, and formate. Med Sci Sports Exerc 2005; 37: 1717-20.
45. Gualano B, de Salles Painelli V, Roschel H, Lugaresi R, Dorea E, Artioli GG, et al. Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial. Eur J Appl Physiol 2011; 111: 749-56.
46. Neves M Jr, Gualano B, Roschel H, Lima FR, Lucia de Sa-Pinto A, Seguro AC, et al. Effect of creatine supplementation on measured glomerular filtration rate in postmenopausal women. Appl Physiol Nutr Metab 2011; 36: 419-22.
47. Gualano B, Ugrinowitsch C, Novaes RB, Artioli GG, Shimizu MH, Seguro AC, et al. Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial. Eur J Appl Physiol 2008; 103: 33-40.
48. Gualano B, Roschel H, Lancha-Jr AH, Brightbill CE, Rawson ES,. In sickness and in health: the widespread application of creatine supplementation. Amino Acids 2011; 43: 519-29.