Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: A double-blind, placebo-controlled study

Skin Pharmacology and Physiology

Volumn 27, Issue 1, 2013, Pages 47-55

  Proksch, E ^a   Segger, D ^b   Degwert, J ^b   Schunck, M ^a   Zague, V ^c   Oesser, S ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b Skin Investigation and Technology   (Germany)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Collagen hydrolysate; Collagen peptides; Elasticity; Hydration; Roughness; Skin

Indexed keywords

COLLAGEN; COLLAGEN HYDROLYSATE; PLACEBO; UNCLASSIFIED DRUG; COLLAGEN DERIVATIVE;

ADULT; AGING; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ELASTICITY; FEMALE; FOLLOW UP; HUMAN; HYDRATION; MAJOR CLINICAL STUDY; MOISTURE; PRIORITY JOURNAL; SKIN CARE; SKIN WATER LOSS; SUPPLEMENTATION; TREATMENT DURATION; ABSENCE OF SIDE EFFECTS; COMPARATIVE STUDY; CUTANEOUS PARAMETERS; DRUG EFFICACY; EVAPORATION; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; RANDOMIZED CONTROLLED TRIAL; SKIN ELASTICITY; SKIN HYDRATION; SKIN MOISTURE; SKIN ROUGHNESS;

ADMINISTRATION, ORAL; ADULT; COLLAGEN; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ELASTICITY; FEMALE; HUMANS; MIDDLE AGED; PEPTIDES; SKIN; SKIN AGING; SURFACE PROPERTIES; WATER;

EID: 84883310857     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000351376     Document Type: Article

References (47)

1. Smalls LK, Randall WR, Visscher MO: Effect of dermal thickness, tissue composition, and body site on skin biomechanical properties. Skin Res Technol 2006; 12: 43-49.
2. Calleja-Agius J, Muscat-Baron Y, Brincat MP: Skin ageing. Menopause Int 2007; 13: 60-64.
3. Draelos ZD: Nutrition and enhancing youthful-appearing skin. Clin Dermatol 2010; 28: 400-408.
4. Zague V: A new view concerning the effects of collagen hydrolysate intake on skin properties. Arch Dermatol Res 2008; 300: 479-483.
5. Ohara H, Matsumoto H, Ito K, Iwai K, Sato K: Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. J Agric Food Chem 2007; 55: 1532-1535.
6. Iwai K, Hasegawa T, Taguchi Y, Morimatsu F, Sato K, Nakamura Y, Higashi A, Kido Y, Nakabo Y, Ohtsuki K: Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem 2005; 53: 6531-6536.
7. Oesser S, Adam M, Babel W, Seifert J: Oral administration of 14 C-labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). J Nutr 1999; 129: 1891-1895.
8. Kim SK, Kim YT, Byun HG, Park PJ, Ito H: Purification and characterization of antioxidative peptides from bovine skin. J Biochem Mol Biol 2001; 34: 219-224.
9. Mendis E, Rajapakse N, Kim SK: Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate. J Agric Food Chem 2005; 53: 581-587.
10. Mendis E, Rajapakse N, Byun HG, Kim SK: Investigation of jumbo squid ( Dosidicus gigas ) skin gelatin peptides for their in vitro antioxidant effects. Life Sci 2005; 77: 2166-2178.
11. Li B, Chen F, Wang X, Ji B, Wu Y: Isolation and identification of antioxidative peptides from porcine collagen hydrolysate by consecutive chromatography and electrospray ionization mass spectrometry. Food Chem 2007; 102: 1135-1143.
12. Postlethwaite AE, Seyer JM, Kang AH: Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci USA 1978; 75: 871-875.
13. Shigemura Y, Iwai K, Morimatsu F, Iwamoto T, Mori T, Oda C, Taira T, Park EY, Nakamura Y, Sato K: Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J Agric Food Chem 2009; 57: 444-449.
14. Matsuda N, Koyama Y, Hosaka Y, Ueda H, Watanabe T, Araya T, Irie S, Takehana K: Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo) 2006; 52: 211-215.
15. Tanaka M, Koyama Y-I, Nomura Y: Effects of collagen peptide ingestion on UVB-induced skin damage. Biosci Biotechnol Biochem 2009; 73: 930-932.
16. Zague V, de F, V, da Costa RM, de Castro GA, Jaeger RG, hado-Santelli GM: Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. J Med Food 2011; 14: 618-624.
17. Segger D, Matthies A, Saldeen T: Supplementation with Eskimo Skin Care improves skin elasticity in women. A pilot study. J Dermatolog Treat 2008; 19: 279-283.
18. Segger D, Schonlau F: Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. J Dermatolog Treat 2004; 15: 222-226.
19. Krueger N, Luebberding S, Oltmer M, Streker M, Kerscher M: Age-related changes in skin mechanical properties: a quantitative evaluation of 120 female subjects. Skin Res Technol 2011; 17: 141-148.
20. Ryu HS, Joo YH, Kim SO, Park KC, Youn SW: Influence of age and regional differences on skin elasticity as measured by the Cutometer. Skin Res Technol 2008; 14: 354-358.
21. Batisse D, Bazin R, Baldeweck T, Querleux B, Leveque JL: Influence of age on the wrinkling capacities of skin. Skin Res Technol 2002; 8: 148-154.
22. Frei V, Perrier E, Orly I, Huc A, Augustin C, Damour O: Activation of fibroblast metabolism in a dermal and skin equivalent model: a screening test for activity of peptides. Int J Cosmet Sci 1998; 20: 159-173.
23. Liang J, Pei X, Zhang Z, Wang N, Wang J, Li Y: The protective effects of long-term oral administration of marine collagen hydrolysate from Chum Salmon on collagen matrix homeostasis in the chronological aged skin of Sprague-Dawley male rats. J Food Sci 2010; 75:H230-H238.
24. Paul C, Maumus-Robert S, Mazereeuw-Hautier J, Guyen CN, Saudez X, Schmitt AM: Prevalence and risk factors for xerosis in the elderly: a cross-sectional epidemiological study in primary care. Dermatology 2011; 223: 260-265.
25. Nishimori Y, Edwars C, Pearse A, Matsumoto K, Kawai M, Marks R. Degenerative alterations of dermal collagen fiber bundles in photodamaged human skin and UV-irradiated hairless mouse skin: possible effect on decreasing skin mechanical properties and appearance of wrinkles. J Invest Dermatol 2001; 117: 1458-1463.
26. Sumino H, Ichikawa S, Abe M, Endo Y, Ishikawa O, Kurabayashi M: Effects of aging, menopause, and hormone replacement therapy on forearm skin elasticity in women. J Am Geriatr Soc 2004; 52: 945-949.
27. Vuillermoz B, Wegrowski Y, Contet-Audonneau JL, Danoux L, Pauly G, Maquart FX: Influence of aging on glycosaminoglycans and small leucine-rich proteoglycans production by skin fibroblasts. Mol Cell Biochem 2005; 277: 63-72.
28. Chung JH, Seo JY, Choi HR, Lee MK, Youn CS, Rhie G, Cho KH, Kim KH, Park KC, Eun HC: Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol 2001; 117: 1218-1224.
29. Tokudome Y, Nakamura K, Kage M, Todo H, Sugibayashi K, Hashimoto F: Effects of soybean peptide and collagen peptide on collagen synthesis in normal human dermal fibroblasts. Int J Food Sci Nutr 2012; 63: 689-695.
30. Castro GA, Maria DA, Bouhallab S, Sgarbieri VC: In vitro impact of a whey protein isolate (WPI) and collagen hydrolysates (CHs) on B16F10 melanoma cell proliferation. J Dermatol Sci 2009; 56: 51-57.
31. Lee J-H, Seo J-H, Park Y-H, Lim K-M, Lee S-J: The effect of hydroxyproline and Pro-Hyp dipeptide on UV-damaged skin of hairless mice. Korean J Food Sci Technol 2008; 40: 436-442.
32. Li GY, Fukunaga S, Takenouchi K, Nakamura F: Comparative study of the physiological properties of collagen, gelatin and collagen hydrolysate as cosmetic materials. Int J Cosmet Sci 2005; 27: 101-106.
33. Pei XR, Yang RY, Zhang ZF, Xu YJ, Han XL, Wang JB, Li Y: Effects of marine collagen peptide on delaying the skin aging. Zhonghua Yu Fang Yi Xue Za Zhi 2008; 42: 235-238.
34. Zhuang Y, Hou H, Zhao X, Zhang Z, Li B: Effects of collagen and collagen hydrolysate from jellyfish ( Rhopilema esculentum ) on mice skin photoaging induced by UV irradiation. J Food Sci 2009; 74:H183-H188.
35. Bauza E, Oberto G, Berghi A, Dal CF, Domloge N: Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. Int J Tissue React 2004; 26: 105-111.
36. Haftek M, Mac-Mary S, Le Bitoux MA, Creidi P, Seite S, Rougier A, Humbert P: Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin. Exp Dermatol 2008; 17: 946-952.
37. Loden M: Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream. Contact Dermatitis 1997; 36: 256-260.
38. Draelos ZD: Active agents in common skin care products. Plast Reconstr Surg 2010; 125: 719-724.
39. Xhauflaire-Uhoda E, Fontaine K, Pierard GE: Kinetics of moisturizing and firming effects of cosmetic formulations. Int J Cosmet Sci 2008; 30: 131-138.
40. Buraczewska I, Berne B, Lindberg M, Torma H, Loden M: Changes in skin barrier function following long-term treatment with moisturizers: a randomized controlled trial. Br J Dermatol 2007; 156: 492-498.
41. Varani J, Warner RL, Gharaee-Kermani M, Phan SH, Kang S, Chung JH, Wang ZQ, Datta SC, Fisher GJ, Voorhees JJ: Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 2000; 114: 480-486.
42. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ: Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med 1997; 337: 1419-1428.
43. Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schonlau F, Krutmann J: Pycnogenol ® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. Skin Pharmacol Physiol 2012; 25: 86-92.
44. Siddappa K: Dry skin conditions, eczema and emollients in their management. Indian J Dermatol Venereol Leprol 2003; 69: 69-75.
45. Baek JH, Lee MY, Koh JS: Relationship between clinical features of facial dry skin and biophysical parameters in Asians. Int J Cosmet Sci 2011; 33: 222-227.
46. Seyfarth F, Schliemann S, Antonov D, Elsner P: Dry skin, barrier function, and irritant contact dermatitis in the elderly. Clin Dermatol 2011; 29: 31-36.
47. Sato J, Yanai M, Hirao T, Denda M: Water content and thickness of the stratum corneum contribute to skin surface morphology. Arch Dermatol Res 2000; 292: 412-417.