Topological plasticity of enzymes involved in disulfide bond formation allows catalysis in either the periplasm or the cytoplasm

Journal of Molecular Biology

Volumn 425, Issue 18, 2013, Pages 3268-3276

  Hatahet, Feras ^a,b   Ruddock, Lloyd W ^a  

^a UNIVERSITY OF OULU   (Finland)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

DsbB; Rational design; Topology inversion; Transmembrane proteins; VKOR

Indexed keywords

ALKALINE PHOSPHATASE; BETA GALACTOSIDASE; BETA LACTAMASE; DISULFIDE BOND FORMING ENZYME B; ENZYME; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; VITAMIN K EPOXIDE REDUCTASE;

AEROPYRUM PERNIX; ARTICLE; BIOLOGICAL ACTIVITY; CATALYSIS; CATALYST; CELL FRACTIONATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DISULFIDE BOND; ELECTRON TRANSPORT; ENZYME ENGINEERING; ENZYME LOCALIZATION; ENZYME METABOLISM; ENZYME SPECIFICITY; ESCHERICHIA COLI; INTRACELLULAR SPACE; MEMBRANE STRUCTURE; NONHUMAN; PLASTICITY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FOLDING; PYROBACULUM AEROPHILUM; WILD TYPE;

AEROPYRUM PERNIX; ESCHERICHIA COLI; PROKARYOTA;

EID: 84883292418     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.04.034     Document Type: Article

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