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Volumn 25, Issue 5, 2013, Pages 588-592

Drug repurposing: a better approach for infectious disease drug discovery?

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIVIRUS AGENT; FIBROBLAST GROWTH FACTOR 2; MESSENGER RNA; QUERCETIN; RESVERATROL; STRESS ACTIVATED PROTEIN KINASE 1; TOPIRAMATE;

EID: 84883292239     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2013.08.004     Document Type: Review
Times cited : (66)

References (29)
  • 1
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: identifying and developing new uses for existing drugs
    • 1 Ashburn, T.T., Thor, K.B., Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 3 (2004), 673–683.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 2
    • 84861904508 scopus 로고    scopus 로고
    • Network pharmacology for cancer drug discovery: are we there yet?
    • 2 Azmi, A.S., Network pharmacology for cancer drug discovery: are we there yet?. Future Med Chem 4 (2012), 939–941.
    • (2012) Future Med Chem , vol.4 , pp. 939-941
    • Azmi, A.S.1
  • 3
    • 80052218993 scopus 로고    scopus 로고
    • Drug repositioning: re-investigating existing drugs for new therapeutic indications
    • 3 Padhy, B.M., Gupta, Y.K., Drug repositioning: re-investigating existing drugs for new therapeutic indications. JPGM 57 (2011), 153–160.
    • (2011) JPGM , vol.57 , pp. 153-160
    • Padhy, B.M.1    Gupta, Y.K.2
  • 4
    • 84877580262 scopus 로고    scopus 로고
    • Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
    • This paper proposes two strategies for using molecular network analysis for discovering novel drug targets, a central hit strategy and a network influence strategy.
    • 4• Csermely, P., Korcsmaros, T., Kiss, H.J., London, G., Nussinov, R., Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review. Pharmacol Ther 138 (2013), 333–408 This paper proposes two strategies for using molecular network analysis for discovering novel drug targets, a central hit strategy and a network influence strategy.
    • (2013) Pharmacol Ther , vol.138 , pp. 333-408
    • Csermely, P.1    Korcsmaros, T.2    Kiss, H.J.3    London, G.4    Nussinov, R.5
  • 5
    • 84862218504 scopus 로고    scopus 로고
    • Drug repurposing through nonhypothesis driven phenotypic screening
    • 5 Reaume, A.G., Drug repurposing through nonhypothesis driven phenotypic screening. Drug Discov Today: Therap Strat 8 (2011), 85–88.
    • (2011) Drug Discov Today: Therap Strat , vol.8 , pp. 85-88
    • Reaume, A.G.1
  • 6
    • 84867338005 scopus 로고    scopus 로고
    • The emergence of genome-based drug repositioning
    • 6 Lussier, Y.A., Chen, J.L., The emergence of genome-based drug repositioning. Sci Transl Med, 3, 2011, 96ps35.
    • (2011) Sci Transl Med , vol.3 , pp. 96ps35
    • Lussier, Y.A.1    Chen, J.L.2
  • 7
    • 33845876254 scopus 로고    scopus 로고
    • The Connectivity Map: a new tool for biomedical research
    • 7 Lamb, J., The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer 7 (2007), 54–60.
    • (2007) Nat Rev Cancer , vol.7 , pp. 54-60
    • Lamb, J.1
  • 11
    • 84879571351 scopus 로고    scopus 로고
    • Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus
    • This is the first use of the inverse genomic signature approach for an emerging infectious disease.
    • 11• Josset, L., Menachery, V.D., Gralinski, L.E., Agnihothram, S., Sova, P., Carter, V.S., Yount, B.L., Graham, R.L., Baric, R.S., Katze, M.G., Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. mBio, 2013, 4 This is the first use of the inverse genomic signature approach for an emerging infectious disease.
    • (2013) mBio , pp. 4
    • Josset, L.1    Menachery, V.D.2    Gralinski, L.E.3    Agnihothram, S.4    Sova, P.5    Carter, V.S.6    Yount, B.L.7    Graham, R.L.8    Baric, R.S.9    Katze, M.G.10
  • 12
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: understanding the cell's functional organization
    • 12 Barabasi, A.L., Oltvai, Z.N., Network biology: understanding the cell's functional organization. Nat Rev Genet 5 (2004), 101–113.
    • (2004) Nat Rev Genet , vol.5 , pp. 101-113
    • Barabasi, A.L.1    Oltvai, Z.N.2
  • 14
    • 84862646763 scopus 로고    scopus 로고
    • Topological analysis of protein co-abundance networks identifies novel host targets important for HCV infection and pathogenesis
    • 14 McDermott, J.E., Diamond, D.L., Corley, C., Rasmussen, A.L., Katze, M.G., Waters, K.M., Topological analysis of protein co-abundance networks identifies novel host targets important for HCV infection and pathogenesis. BMC Syst Biol, 6, 2012, 28.
    • (2012) BMC Syst Biol , vol.6 , pp. 28
    • McDermott, J.E.1    Diamond, D.L.2    Corley, C.3    Rasmussen, A.L.4    Katze, M.G.5    Waters, K.M.6
  • 15
    • 84879414041 scopus 로고    scopus 로고
    • Systems virology: host-directed approaches to viral pathogenesis and drug targeting
    • 15 Law, G.L., Korth, M.J., Benecke, A.G., Katze, M.G., Systems virology: host-directed approaches to viral pathogenesis and drug targeting. Nat Rev Microbiol 11 (2013), 455–466.
    • (2013) Nat Rev Microbiol , vol.11 , pp. 455-466
    • Law, G.L.1    Korth, M.J.2    Benecke, A.G.3    Katze, M.G.4
  • 16
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: a network-based approach to human disease
    • 16 Barabasi, A.L., Gulbahce, N., Loscalzo, J., Network medicine: a network-based approach to human disease. Nat Rev Genet 12 (2011), 56–68.
    • (2011) Nat Rev Genet , vol.12 , pp. 56-68
    • Barabasi, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 17
    • 84877743291 scopus 로고    scopus 로고
    • Network-based drug repositioning
    • 17 Wu, Z., Wang, Y., Chen, L., Network-based drug repositioning. Mol Biosyst 9 (2013), 1268–1281.
    • (2013) Mol Biosyst , vol.9 , pp. 1268-1281
    • Wu, Z.1    Wang, Y.2    Chen, L.3
  • 21
    • 84868098780 scopus 로고    scopus 로고
    • Opportunities in systems biology to discover mechanisms and repurpose drugs for CNS diseases
    • 21 Mei, H., Xia, T., Feng, G., Zhu, J., Lin, S.M., Qiu, Y., Opportunities in systems biology to discover mechanisms and repurpose drugs for CNS diseases. Drug Discov Today 17 (2012), 1208–1216.
    • (2012) Drug Discov Today , vol.17 , pp. 1208-1216
    • Mei, H.1    Xia, T.2    Feng, G.3    Zhu, J.4    Lin, S.M.5    Qiu, Y.6
  • 22
    • 84863691513 scopus 로고    scopus 로고
    • Drug repositioning through incomplete bi-cliques in an integrated drug–target–disease network
    • The novel computational approach described in this paper is an excellent example of integrating two data types into a single topological network.
    • 22• Daminelli, S., Haupt, V.J., Reimann, M., Schroeder, M., Drug repositioning through incomplete bi-cliques in an integrated drug–target–disease network. Integr Biol 4 (2012), 778–788 The novel computational approach described in this paper is an excellent example of integrating two data types into a single topological network.
    • (2012) Integr Biol , vol.4 , pp. 778-788
    • Daminelli, S.1    Haupt, V.J.2    Reimann, M.3    Schroeder, M.4
  • 23
    • 44949251035 scopus 로고    scopus 로고
    • Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet
    • 23 Stewart, L.K., Soileau, J.L., Ribnicky, D., Wang, Z.Q., Raskin, I., Poulev, A., Majewski, M., Cefalu, W.T., Gettys, T.W., Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism 57:Suppl 1 (2008), S39–S46.
    • (2008) Metabolism , vol.57 , pp. S39-S46
    • Stewart, L.K.1    Soileau, J.L.2    Ribnicky, D.3    Wang, Z.Q.4    Raskin, I.5    Poulev, A.6    Majewski, M.7    Cefalu, W.T.8    Gettys, T.W.9
  • 24
    • 0346059361 scopus 로고    scopus 로고
    • The French paradox: lessons for other countries
    • 24 Ferrières, J., The French paradox: lessons for other countries. Heart 90 (2004), 107–111.
    • (2004) Heart , vol.90 , pp. 107-111
    • Ferrières, J.1
  • 25
    • 78649927272 scopus 로고    scopus 로고
    • Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4 hydrolase
    • 25 Oi, N., Jeong, C.-H., Nadas, J., Cho, Y.-Y., Pugliese, A., Bode, A.M., Dong, Z., Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A4 hydrolase. Cancer Res 70 (2010), 9755–9764.
    • (2010) Cancer Res , vol.70 , pp. 9755-9764
    • Oi, N.1    Jeong, C.-H.2    Nadas, J.3    Cho, Y.-Y.4    Pugliese, A.5    Bode, A.M.6    Dong, Z.7
  • 26
    • 78650774201 scopus 로고    scopus 로고
    • Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells
    • 26 Chen, Q., Ganapathy, S., Singh, K.P., Shankar, S., Srivastava, R.K., Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS ONE, 5, 2010, e15288.
    • (2010) PLoS ONE , vol.5 , pp. e15288
    • Chen, Q.1    Ganapathy, S.2    Singh, K.P.3    Shankar, S.4    Srivastava, R.K.5
  • 27
    • 78651428992 scopus 로고    scopus 로고
    • Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling
    • 27 He, X., Wang, Y., Zhu, J., Orloff, M., Eng, C., Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer Lett 301 (2011), 168–176.
    • (2011) Cancer Lett , vol.301 , pp. 168-176
    • He, X.1    Wang, Y.2    Zhu, J.3    Orloff, M.4    Eng, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.