A novel approach localizes the association of vitamin D status with insulin resistance to one region of the 25-Hydroxyvitamin D continuum

Advances in Nutrition

Volumn 4, Issue 3, 2013, Pages 303-310

  Heaney, Robert P ^a   French, Christine B ^b   Nguyen, Stacie ^b   Ferreira, Mia ^b   Baggerly, Leo L ^b   Brunel, Ludovic ^c   Veugelers, Paul ^d  

^a CREIGHTON UNIVERSITY   (United States)

^b GrassrootsHealth   (United States)

^c Pure North s'Energy Foundation   (Canada)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

25-HYDROXYVITAMIN D; INSULIN; VITAMIN D; 25 HYDROXYVITAMIN D; DRUG DERIVATIVE;

ADOLESCENT; ADULT; AGE; AGED; ANALOGS AND DERIVATIVES; BLOOD; BLOOD PRESSURE; BODY MASS; BODY WEIGHT; CANADA; FEMALE; HUMAN; INSULIN RESISTANCE; MALE; MIDDLE AGED; PHYSIOLOGY; REGRESSION ANALYSIS; RISK FACTOR; SEX DIFFERENCE; VERY ELDERLY; WAIST CIRCUMFERENCE; YOUNG ADULT; ARTICLE;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BLOOD PRESSURE; BODY MASS INDEX; BODY WEIGHT; CANADA; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; REGRESSION ANALYSIS; RISK FACTORS; SEX FACTORS; VITAMIN D; WAIST CIRCUMFERENCE; YOUNG ADULT;

EID: 84883285848     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.113.003731     Document Type: Article

References (44)

1. Borges MC, Martini LA, Rogero MM. Current perspectives on vitamin D, immune system, and chronic diseases. Nutrition. 2011; 27: 399-404.
2. Kaviani M, Abdollahian M, Almasi V, Amini M, Yamini AA. Effects of vitamin D on insulin resistance in nursing home residents: an interventional study. Endocrynol Pol. 2012; 63: 191-5.
3. Miñambres I, Sánchez-Hernández J, Sánchez-Quesada JL, Rodríguez J, de Leiva A, Pérez A. The association of hypovitaminosis D with the metabolic syndrome is independent of the degree of obesity. ISRN Endocrinology 2012; 2012: 691803.
4. Khan H, Knuutsor S, Franco OH, Chowdhury R. Vitamin D, type 2 diabetes and other metabolic outcomes: a systematic review and metaanalysis of prospective studies. Proc Nutr Soc. 2013; 72: 89-97.
5. Jialal I. Vitamin D intake and status are associated with lower prevalence of metabolic syndrome in U.S. adults: National Health and Nutrition Examination Surveys 2003-2006. Metab Syndr Relat Disord. 2012; 10: 1-2.
6. Simha V, Mahmood M, Ansari M, Spellman CW, Shah P. Effect of vitamin D replacement on insulin sensitivity in subjects with vitamin D deficiency. J Investig Med. 2012; 60: 1214-8.
7. George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med. 2012; 29: e142-50.
8. Brouwer-Brolsma EM, Feskens EJM, Steegenga WT, de Groot LCPGM. Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study. Eur J Nutr. 2012 Epub 2012 Jun 23.
9. Holick MF. D-iabetes and D-eath D-efying vitamin D. Nat Rev Endocrinol. 2012; 8: 388-90.
10. Fung GJ, Steffen LM, Zhou X, Harnack L, Tang W, Lutsey PL, Loria CM, Reis JP, Van Horn LV. Vitamin D intake is inversely related to risk of developing metabolic syndrome in African American and white men and women over 20 y: the Coronary Artery Risk Development in Young Adults study. Am J Clin Nutr. 2012; 96: 24-9.
11. Deleskog A, Hilding A, Brismar K, Hamsten A, Efendic S, Östenson CG. Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia. 2012; 55: 1668-78.
12. Patra SK, Nasrat H, Goswami B, Jain A. Vitamin D as a predictor of insulin resistance in polycystic ovarian syndrome. Diabetes Metab Syndr. 2012; 6: 146-9.
13. Muscogiuri G, Sorice GP, Ajjan R, Mezza T, Pilz S, Prioletta A, Scragg R, Volpe SL, Witham MD, Giaccari A. Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives. Nutr Metab Cardiovasc Dis. 2012; 22: 81-7.
14. Hyppönen E, Power C. Vitamin D status and glucose homeostasis in the 1058 British Birth Cohort. Diabetes Care. 2006; 29: 2244-6.
15. Chiu KC, Chu A, Go LW, Saad MF. Hypovitaminosis D is associated with insulin resistance and b cell dysfunction. Am J Clin Nutr. 2004; 79: 820-5.
16. Tzotzas T, Papadopoulou FG, Tziomalos K, Karras S, Gastaris K, Perros P, Krassas GE. Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance. J Clin Endocrinol Metab. 2010; 95: 4251-7.
17. Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, Sikaris K, Ebeling PR, Daly RM. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab. 2012; 97: 1953-61.
18. Forouhi NG, Ye Z, Rickard AP, Shaw KT, Luben R, Langenberg C, Wareham NJ. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia. 2012; 55: 2173-82.
19. Kabadi SM, Lee BK, Liu L. Joint effects of obesity and vitamin D insufficiency on insulin resistance and type 2 diabetes: results from the NHANES 2001-2006. Diabetes Care. 2012; 35: 2048-54.
20. Hutchinson MS, Figenschau Y, Almås B, Njølstad I, Jorde R. Serum 25-hydroxyvitamin D levels in subjects with reduced glucose tolerance and type 2 diabetes-the Tromsø OGTT-study. Int J Vitam Nutr Res. 2011; 81: 317-27.
21. Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr. 2011; 65: 1005-15.
22. Pham NM, Akter S, Kurotani K, Nanri A, Sato M, Hayabuchi H, Yasuda K, Mizoue T. Serum 25-hydroxyvitamin D and markers of insulin resistance in a Japanese working population. Eur J Clin Nutr. 2012; 66: 1323-8.
23. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care. 2007; 30: 980-6.
24. von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient-a randomized placebo-controlled trial. Br J Nutr. 2010; 103: 549-55.
25. Belenchia AM, Tosh AK, Hillman LS, Peterson CA. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr. Epub 2013 Feb 13.
26. Pfeifer M, Begerow B, Minne HW, Nachtigall D, Hansen C. Effects of a short-term vitamin D3 and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab. 2001; 86: 1633-7.
27. Bischoff-Ferrari HA, Dawson-Hughes B, Stöcklin E, Sidelnikov E, Willett WC, Orav EJ, Stähelin HB, Wolfram S, Jetter A, Schwager J, et al. Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity. J Bone Miner Res. 2012; 27: 160-9.
28. Larsen T, Mose FH, Bech JN, Hansen AB, Pedersen EB. Effect of cholecalciferol supplementation during winter months in patients with hypertension: a randomized, placebo-controlled trial. Am J Hypertens. 2012; 25: 1215-22.
29. Zhou C, Lu F, Cao K, Xu D, Goltzman D, Miao D. Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1-alpha-hydroxylase knockout mice. Kidney Int. 2008; 74: 170-9.
30. Heaney RP, Vitamin D. Basal status and effective dose. N Engl J Med. 2012; 367: 77-8.
31. Biesalski HK, Aggett PJ, Anton R, Bernstein PS, Blumberg J, Heaney RP, Henry J, Nolan JM, Richardson DP, van Ommen B, et al. 26th Hohenheim Consensus Conference, September 11, 2010: Scientific substantiation of health claims: evidence-based nutrition. Nutrition. 2011; 27: S1-20.
32. Parker J, Hashmi O, Dutton D, Mavrodaris A, Stranges S, Kandala NB, Clarke A, Franco OH. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas. 2010; 65: 225-36.
33. Geleijnse JM. Vitamin D and the prevention of hypertension and cardiovascular diseases: a review of the current evidence. Am J Hypertens. 2011; 24: 253-62.
34. Pilz S, Tomaschitz A. Role of vitamin D in arterial hypertension. Expert Rev Cardiovasc Ther. 2010; 8: 1599-608.
35. Burgaz A, Orsini N, Larsson SC, Wolk A. Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis. J Hypertens. 2011; 29: 636-45.
36. Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, Curhan GC. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007; 49: 1063-9.
37. Ardabili HR, Gargari BP, Farzadi L. Vitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency. Nutr Res. 2012; 32: 195-201.
38. Lamendola CA, Ariel D, Feldman D, Reaven GM. Relations between obesity, insulin resistance, and 25-hydroxyvitamin D. Am J Clin Nutr. 2012; 95: 1055-9.
39. Del Gobbo LC, Song Y, Dannenbaum DA, Dewailly E, Egeland GM. Serum 25-hydroxyvitamin D is not associated with insulin resistance or beta cell function in Canadian Cree. J Nutr. 2011; 141: 290-5.
40. Bonora E, Saggiani F, Targher G, Zenere MB, Alberiche M, Monauni T, Bonadonna RC, Muggeo M. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity-studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 2000; 23: 57-63.
41. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000; 85: 2402-10.
42. Willett WC. Nutritional epidemiology. 2nd ed. New York, NY: Oxford University Press; 1998. p. 13.
43. IOM (Institute of Medicine). Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academies Press; 2011.
44. Cavalier E, Delanaye P, Souberbielle J-C, Radermecker R-P. Vitamin D and type 2 diabetes mellitus: where do we stand? Diabetes Metab. 2011; 37: 265-72.