메뉴 건너뛰기




Volumn 20, Issue 5, 2013, Pages 430-436

Treatment with novel oral anticoagulants: Indications, efficacy and risks

Author keywords

apixaban; dabigatran; novel oral anticoagulant; rivaroxaban

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; DABIGATRAN; DABIGATRAN ETEXILATE; EDOXABAN; ENOXAPARIN; PLACEBO; RIVAROXABAN; WARFARIN;

EID: 84883273141     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e328363c170     Document Type: Review
Times cited : (26)

References (54)
  • 1
    • 77952167209 scopus 로고    scopus 로고
    • Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
    • Stangier J, Clemens A. Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor. Clin Appl Thromb/Hemost 2009; 15:09S-16S.
    • (2009) Clin Appl Thromb/Hemost , vol.15
    • Stangier, J.1    Clemens, A.2
  • 2
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    • Blech S, Ebner T, Ludwig-Schwellinger E, et al. The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos 2008; 36:386-399.
    • (2008) Drug Metab Dispos , vol.36 , pp. 386-399
    • Blech, S.1    Ebner, T.2    Ludwig-Schwellinger, E.3
  • 3
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate: A novel, reversible, oral direct thrombin inhibitor - Interpretation of coagulation assays and reversal of anticoagulant activity
    • van Ryn J, Stangier J, Haertter S, et al. Dabigatran etexilate: a novel, reversible, oral direct thrombin inhibitor - interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010; 103:1116-1127.
    • (2010) Thromb Haemost , vol.103 , pp. 1116-1127
    • Van Ryn, J.1    Stangier, J.2    Haertter, S.3
  • 4
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly S, Ezekowitz M, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361:1139-1151.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.1    Ezekowitz, M.2    Yusuf, S.3
  • 6
    • 84866524336 scopus 로고    scopus 로고
    • Novel oral anticoagulants for stroke prevention in atrial fibrillation: Focus on apixaban
    • Potpara TS, Polovina MM, Licina MM, et al. Novel oral anticoagulants for stroke prevention in atrial fibrillation: focus on apixaban. Adv Ther 2012; 29:491-507.
    • (2012) Adv Ther , vol.29 , pp. 491-507
    • Potpara, T.S.1    Polovina, M.M.2    Licina, M.M.3
  • 7
    • 78650587760 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after hip replacement
    • Lassen M, Gallus A, Raskob G, et al. Apixaban versus enoxaparin for thromboprophylaxis after hip replacement. N Engl J Med 2010; 363: 2487-2498.
    • (2010) N Engl J Med , vol.363 , pp. 2487-2498
    • Lassen, M.1    Gallus, A.2    Raskob, G.3
  • 8
    • 66449099711 scopus 로고    scopus 로고
    • Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs and humans
    • Weinz C, Schwarz T, Kubitza D, et al. Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs and humans. Drug Metab Dispos 2009; 37:1056-1064.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1056-1064
    • Weinz, C.1    Schwarz, T.2    Kubitza, D.3
  • 9
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel MR, Mahaffey KW, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011; 365:883-891.
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 10
    • 84859385808 scopus 로고    scopus 로고
    • Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • Buller HR, Prins MH, Lensing A, et al. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 2012; 366:1287-1297.
    • (2012) N Engl J Med , vol.366 , pp. 1287-1297
    • Buller, H.R.1    Prins, M.H.2    Lensing, A.3
  • 11
    • 78650619315 scopus 로고    scopus 로고
    • Oral rivaroxaban for symptomatic venous thromboembolism
    • Bauersachs R, Berkowitz SD, Brenner B, et al. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010; 363:2499-2510.
    • (2010) N Engl J Med , vol.363 , pp. 2499-2510
    • Bauersachs, R.1    Berkowitz, S.D.2    Brenner, B.3
  • 12
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • Granger C, Alexander J, McMurray J, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011; 365:981-992.
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.1    Alexander, J.2    McMurray, J.3
  • 13
    • 79960272135 scopus 로고    scopus 로고
    • Edoxaban a new oral direct factor Xa inhibitor
    • Camm AJ, Bounameaux H. Edoxaban a new oral direct factor Xa inhibitor. Drugs 2011; 71:1503-1526.
    • (2011) Drugs , vol.71 , pp. 1503-1526
    • Camm, A.J.1    Bounameaux, H.2
  • 14
    • 77953787643 scopus 로고    scopus 로고
    • Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers
    • Ogata K, Mendell-Harary J, Tachibana M, et al. Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J Clin Pharmacol 2010; 50:743-753.
    • (2010) J Clin Pharmacol , vol.50 , pp. 743-753
    • Ogata, K.1    Mendell-Harary, J.2    Tachibana, M.3
  • 15
    • 36348978071 scopus 로고    scopus 로고
    • The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement
    • Lassen MR, Davidson BL, Gallus A, et al. The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. J Thromb Haemost 2007; 5:2368-2375.
    • (2007) J Thromb Haemost , vol.5 , pp. 2368-2375
    • Lassen, M.R.1    Davidson, B.L.2    Gallus, A.3
  • 16
    • 68249158084 scopus 로고    scopus 로고
    • Apixaban or enoxaparin for thromboprophylaxis after knee replacement
    • Lassen MR, Raskob GE, Gallus A, et al. Apixaban or enoxaparin for thromboprophylaxis after knee replacement. N Engl J Med 2009; 361:594-604.
    • (2009) N Engl J Med , vol.361 , pp. 594-604
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3
  • 17
    • 77649113258 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): A randomised double-blind trial
    • Lassen MR, Raskob GE, Gallus A, et al. Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial. Lancet 2010; 375:807-815.
    • (2010) Lancet , vol.375 , pp. 807-815
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3
  • 18
    • 35449007749 scopus 로고    scopus 로고
    • Oral dabigatran etexilate vs. Subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: The RE-MODEL randomized trial
    • Eriksson BI, Dahl OE, Rosencher N, et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost 2007; 5:2178-2185.
    • (2007) J Thromb Haemost , vol.5 , pp. 2178-2185
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 19
    • 57649123692 scopus 로고    scopus 로고
    • Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery
    • Ginsberg J, Davidson B, Comp P, et al. Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty 2009; 24:1-9.
    • (2009) J Arthroplasty , vol.24 , pp. 1-9
    • Ginsberg, J.1    Davidson, B.2    Comp, P.3
  • 20
    • 34548575058 scopus 로고    scopus 로고
    • Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: A randomised, double-blind, noninferiority trial
    • Eriksson BI, Dahl OE, Rosencher N, et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, noninferiority trial. Lancet 2007; 370:949-956.
    • (2007) Lancet , vol.370 , pp. 949-956
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 21
    • 79953836474 scopus 로고    scopus 로고
    • Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II)
    • Erikkson BI, Dahl OE, Huo MH, et al. Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II). Thromb Haemost 2011; 105:721-729.
    • (2011) Thromb Haemost , vol.105 , pp. 721-729
    • Erikkson, B.I.1    Dahl, O.E.2    Huo, M.H.3
  • 22
    • 45949103416 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    • Lassen MR, Ageno W, Borris LC, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008; 358:2776-2786.
    • (2008) N Engl J Med , vol.358 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 23
    • 45949099359 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    • Eriksson BI, Borris LC, Friedman RJ, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med 2008; 358:2765-2775.
    • (2008) N Engl J Med , vol.358 , pp. 2765-2775
    • Eriksson, B.I.1    Borris, L.C.2    Friedman, R.J.3
  • 24
    • 84863224773 scopus 로고    scopus 로고
    • Dabigatran, rivaroxaban, or apixaban versus enoxaparin for thromboprophylaxis after total hip or knee replacement: Systematic review, meta-analysis, and indirect treatment comparisons
    • Gómez-Outes A, Terleira-Fernández AI, Suárez-Gea ML, Vargas-Castrillón E. Dabigatran, rivaroxaban, or apixaban versus enoxaparin for thromboprophylaxis after total hip or knee replacement: systematic review, meta-analysis, and indirect treatment comparisons. BMJ 2012; 344:1-16.
    • (2012) BMJ , vol.344 , pp. 1-16
    • Gómez-Outes, A.1    Terleira-Fernández, A.I.2    Suárez-Gea, M.L.3    Vargas-Castrillón, E.4
  • 25
    • 84864410509 scopus 로고    scopus 로고
    • Dabigatran, rivaroxaban and apixaban versus enoxaparin for thomboprophylaxis after total knee or hip arthroplasty: Pool-analysis of phase III randomized clinical trials
    • Nieto JA, Espada NG, Merino RG, González TC. Dabigatran, rivaroxaban and apixaban versus enoxaparin for thomboprophylaxis after total knee or hip arthroplasty: pool-analysis of phase III randomized clinical trials. Thromb Res 2012; 130:183-191.
    • (2012) Thromb Res , vol.130 , pp. 183-191
    • Nieto, J.A.1    Espada, N.G.2    Merino, R.G.3    González, T.C.4
  • 26
    • 78149236861 scopus 로고    scopus 로고
    • A dose-ranging study evaluating the oral factor Xa inhibitor edoxaban for the prevention of venous thromboembolism in patients undergoing total knee arthroplasty
    • Fuji T, Fujita S, Tachibana S, Kawai Y. A dose-ranging study evaluating the oral factor Xa inhibitor edoxaban for the prevention of venous thromboembolism in patients undergoing total knee arthroplasty. J Thromb Haemost 2010; 8:2458-2468.
    • (2010) J Thromb Haemost , vol.8 , pp. 2458-2468
    • Fuji, T.1    Fujita, S.2    Tachibana, S.3    Kawai, Y.4
  • 27
    • 77956628530 scopus 로고    scopus 로고
    • Oral direct factor Xa inhibition with edoxaban for thromboprophylaxis after elective total hip replacement: A randomised double-blind dose-response study
    • Raskob G, Cohen AT, Erikkson BI, et al. Oral direct factor Xa inhibition with edoxaban for thromboprophylaxis after elective total hip replacement: a randomised double-blind dose-response study. Thromb Haemost 2010; 104:642-649.
    • (2010) Thromb Haemost , vol.104 , pp. 642-649
    • Raskob, G.1    Cohen, A.T.2    Erikkson, B.I.3
  • 28
    • 47649098524 scopus 로고    scopus 로고
    • Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study
    • Buller H, Deitchman D, Prins M, Segers A. Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study. J Thromb Haemost 2008; 6:1313-1318.
    • (2008) J Thromb Haemost , vol.6 , pp. 1313-1318
    • Buller, H.1    Deitchman, D.2    Prins, M.3    Segers, A.4
  • 29
    • 84878713682 scopus 로고    scopus 로고
    • Apixaban for extended treatment of venous thromboembolism
    • published online December, 2012
    • Anelli G, Buller H, Cohen A, et al. Apixaban for extended treatment of venous thromboembolism. N Engl J Med 2012; published online December 8, 2012.
    • (2012) N Engl J Med , vol.8
    • Anelli, G.1    Buller, H.2    Cohen, A.3
  • 30
    • 84870517411 scopus 로고    scopus 로고
    • Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism a systematic review
    • Adam SS, McDuffie JR, Ortel TL, Williams JW. Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism a systematic review. Ann Intern Med 2012; 157:796-807.
    • (2012) Ann Intern Med , vol.157 , pp. 796-807
    • Adam, S.S.1    McDuffie, J.R.2    Ortel, T.L.3    Williams, J.W.4
  • 31
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • Schulman S, Kearon C, Kakkar A, et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009; 361:2342-2352.
    • (2009) N Engl J Med , vol.361 , pp. 2342-2352
    • Schulman, S.1    Kearon, C.2    Kakkar, A.3
  • 32
    • 84862530985 scopus 로고    scopus 로고
    • A randomized trial of dabigatran versus warfarin in the treatment of acute venous thromboembolism (RECOVER II)
    • Abstract 205, San Diego
    • Schulman S, Kakkar A, Schellong S, et al. A randomized trial of dabigatran versus warfarin in the treatment of acute venous thromboembolism (RECOVER II); Proceedings of American Society of Hematology Conference; 2011. Abstract 205, San Diego.
    • (2011) Proceedings of American Society of Hematology Conference
    • Schulman, S.1    Kakkar, A.2    Schellong, S.3
  • 33
    • 84874003257 scopus 로고    scopus 로고
    • Extended use of dabigatran, warfarin, or placebo in venous thromboembolism
    • Schulman S, Kearon C, Kakkar A, et al. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. N Engl J Med 2013; 368:709-718.
    • (2013) N Engl J Med , vol.368 , pp. 709-718
    • Schulman, S.1    Kearon, C.2    Kakkar, A.3
  • 34
    • 84863981277 scopus 로고    scopus 로고
    • Meta-analysis of efficacy and safety of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus warfarin in patients with atrial fibrillation
    • Miller CS, Grandi SM, Shimony A, et al. Meta-analysis of efficacy and safety of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus warfarin in patients with atrial fibrillation. Am J Cardiol 2012; 110:453-460.
    • (2012) Am J Cardiol , vol.110 , pp. 453-460
    • Miller, C.S.1    Grandi, S.M.2    Shimony, A.3
  • 35
    • 84864387139 scopus 로고    scopus 로고
    • Randomized, multicenter, warfarincontrolled phase II study of edoxaban in japanese patients with non-valvular atrial fibrillation
    • Yamashita T, Koretsune Y, YasakaM, et al. Randomized, multicenter, warfarincontrolled phase II study of edoxaban in japanese patients with non-valvular atrial fibrillation. Circ J 2012; 76:1840-1847.
    • (2012) Circ J , vol.76 , pp. 1840-1847
    • Yamashita, T.1    Yasakam, K.Y.2
  • 36
    • 77954361232 scopus 로고    scopus 로고
    • Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation
    • Weitz JI, Connolly SJ, Patel I, et al. Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation. Thromb Haemost 2010; 104:633-641.
    • (2010) Thromb Haemost , vol.104 , pp. 633-641
    • Weitz, J.I.1    Connolly, S.J.2    Patel, I.3
  • 37
    • 79952513881 scopus 로고    scopus 로고
    • Safety of edoxaban, an oral factor Xa inhibitor, in Asian patients with nonvalvular atrial fibrillation
    • Chung N, Jeon HK, Lien LM, et al. Safety of edoxaban, an oral factor Xa inhibitor, in Asian patients with nonvalvular atrial fibrillation. Thromb Haemost 2010; 105:535-545.
    • (2010) Thromb Haemost , vol.105 , pp. 535-545
    • Chung, N.1    Jeon, H.K.2    Lien, L.M.3
  • 38
    • 77957932391 scopus 로고    scopus 로고
    • Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: Design and rationale for the effective anticoagulation with factor xA next generation in atrial fibrillation-thrombolysis in myocardial infarction study 48 (ENGAGE AF-TIMI 48)
    • Ruff CT, Giugliano RP, Antman EM, et al. Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the effective anticoagulation with factor xA next generation in atrial fibrillation-thrombolysis in myocardial infarction study 48 (ENGAGE AF-TIMI 48). Am Heart J 2010; 160:635-641.
    • (2010) Am Heart J , vol.160 , pp. 635-641
    • Ruff, C.T.1    Giugliano, R.P.2    Antman, E.M.3
  • 39
    • 79958126202 scopus 로고    scopus 로고
    • Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial
    • Eikelboom J, Wallentin L, Connolly S, et al. Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial. Circulation 2011; 123:2363-2372.
    • (2011) Circulation , vol.123 , pp. 2363-2372
    • Eikelboom, J.1    Wallentin, L.2    Connolly, S.3
  • 40
    • 79952301326 scopus 로고    scopus 로고
    • Apixaban in patients with atrial fibrillation
    • Connolly SJ, Eikelboom J, Joyner C, et al. Apixaban in patients with atrial fibrillation. N Engl J Med 2011; 364:806-817.
    • (2011) N Engl J Med , vol.364 , pp. 806-817
    • Connolly, S.J.1    Eikelboom, J.2    Joyner, C.3
  • 41
    • 84864138390 scopus 로고    scopus 로고
    • Stroke risk and efficacy of apixaban in atrial fibrillation patients with moderate chronic kidney disease
    • Eikelboom JE, Connolly SJ, Gao P, et al. Stroke risk and efficacy of apixaban in atrial fibrillation patients with moderate chronic kidney disease. J Stroke Cerebrovasc Dis 2012; 21:429-435.
    • (2012) J Stroke Cerebrovasc Dis , vol.21 , pp. 429-435
    • Eikelboom, J.E.1    Connolly, S.J.2    Gao, P.3
  • 42
    • 67649563209 scopus 로고    scopus 로고
    • Apixaban an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: Results of the apixaban for prevention of acute ischemic and safety events (APPRAISE) trial
    • APPRAISE Steering Committee and Investigators
    • APPRAISE Steering Committee and Investigators. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the apixaban for prevention of acute ischemic and safety events (APPRAISE) trial. Circulation 2009; 119:2877-2885.
    • (2009) Circulation , vol.119 , pp. 2877-2885
  • 43
    • 80052162121 scopus 로고    scopus 로고
    • Apixaban with antiplatelet therapy after acute coronary syndrome
    • Alexander J, Lopes R, James S, et al. Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med 2011; 365:699-708.
    • (2011) N Engl J Med , vol.365 , pp. 699-708
    • Alexander, J.1    Lopes, R.2    James, S.3
  • 44
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • Mega JL, Braunwald E, Wiviott SD, et al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med 2012; 366:9-19.
    • (2012) N Engl J Med , vol.366 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 45
    • 84857021520 scopus 로고    scopus 로고
    • Dabigatran association with higher risk of acute coronary events meta-analysis of noninferiority randomized controlled trials
    • Uchino K, Hernandez AV. Dabigatran association with higher risk of acute coronary events meta-analysis of noninferiority randomized controlled trials. Arch Intern Med 2012; 172:397-402.
    • (2012) Arch Intern Med , vol.172 , pp. 397-402
    • Uchino, K.1    Hernandez, A.V.2
  • 46
    • 83155193223 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients
    • Goldhaber S, Leizorovicz A, Kakkar A, et al. Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients. N Engl J Med 2011; 365:2167-2177.
    • (2011) N Engl J Med , vol.365 , pp. 2167-2177
    • Goldhaber, S.1    Leizorovicz, A.2    Kakkar, A.3
  • 47
    • 84873514413 scopus 로고    scopus 로고
    • Rivaroxaban for thromboprophylaxis in acutely ill medical patients
    • Cohen AT, Spiro TE, Buller HR, et al. Rivaroxaban for thromboprophylaxis in acutely ill medical patients. N Engl J Med 2013; 368:513-523.
    • (2013) N Engl J Med , vol.368 , pp. 513-523
    • Cohen, A.T.1    Spiro, T.E.2    Buller, H.R.3
  • 48
    • 84878460192 scopus 로고    scopus 로고
    • A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa
    • Lu G, DeGuzman FR, Hollenbach SJ, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med 2013; 19:446-451.
    • (2013) Nat Med , vol.19 , pp. 446-451
    • Lu, G.1    Deguzman, F.R.2    Hollenbach, S.J.3
  • 49
    • 80052408267 scopus 로고    scopus 로고
    • Dabigatran anticoagulant activity is neutralized by an antibody selective to dabigatran in in vitro and in vivo models
    • van Ryn J, Litzenburger T, Waterman A, et al. Dabigatran anticoagulant activity is neutralized by an antibody selective to dabigatran in in vitro and in vivo models. JACC 2011; 57:E1130.
    • (2011) JACC , vol.57
    • Van Ryn, J.1    Litzenburger, T.2    Waterman, A.3
  • 51
    • 84864370719 scopus 로고    scopus 로고
    • Effect of nonspecific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers
    • Marlu R, Hodaj E, Paris A, et al. Effect of nonspecific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers. Thromb Haemost 2012; 108:217-224.
    • (2012) Thromb Haemost , vol.108 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3
  • 52
    • 84865773023 scopus 로고    scopus 로고
    • Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model
    • Pragst I, Zeitler SH, Doerr B, et al. Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model. J Thromb Haemost 2012; 10:1841-1848.
    • (2012) J Thromb Haemost , vol.10 , pp. 1841-1848
    • Pragst, I.1    Zeitler, S.H.2    Doerr, B.3
  • 53
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebocontrolled, crossover study in healthy subjects
    • Eerenberg ES, Kamphuisen PW, Sijpkens MK, et al. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebocontrolled, crossover study in healthy subjects. Circulation 2011; 124:1573-1579.
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3
  • 54
    • 60849097858 scopus 로고    scopus 로고
    • A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT)
    • Turpie AGG, Bauer KA, Davidson BL, et al. A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT). Thromb Haemost 2009; 101:68-76.
    • (2009) Thromb Haemost , vol.101 , pp. 68-76
    • Agg, T.1    Bauer, K.A.2    Davidson, B.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.