메뉴 건너뛰기




Volumn 6, Issue , 2013, Pages 1111-1118

Potential of ponatinib to treat chronic myeloid leukemia and acute lymphoblastic leukemia

Author keywords

BCR ABL; Philadelphia chromosome; T315I; TKI; Tyrosine kinase inhibitor

Indexed keywords

BOSUTINIB; DASATINIB; IMATINIB; NILOTINIB; PONATINIB;

EID: 84883265392     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S36980     Document Type: Review
Times cited : (30)

References (23)
  • 1
    • 84877736487 scopus 로고    scopus 로고
    • Trends in Chronic myeloid leukemia incidence and survival in the United States from 1975-2009
    • Chen Y, Wang H, Hagpo K, Cortes J. Trends in Chronic myeloid leukemia incidence and survival in the United States from 1975-2009. Leuk Lymphoma. 2013;54(7):1411-1417.
    • (2013) Leuk Lymphoma. , vol.54 , Issue.7 , pp. 1411-1417
    • Chen, Y.1    Wang, H.2    Hagpo, K.3    Cortes, J.4
  • 2
    • 84883307407 scopus 로고    scopus 로고
    • East Hanover, NJ: Novartis Pharmaceuticals Corporation
    • Gleevec [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2012.
    • (2012) Gleevec [package insert]
  • 3
    • 84883267965 scopus 로고    scopus 로고
    • Princenton, NJ: Bristol-Myers Squibb
    • Sprycel [package insert]. Princenton, NJ: Bristol-Myers Squibb; 2012.
    • (2012) Sprycel [package insert]
  • 4
    • 84883245633 scopus 로고    scopus 로고
    • East Hanover, NJ: Novartis Pharmaceuticals Corporation
    • Tasigna [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2012.
    • (2012) Tasigna [package insert]
  • 5
    • 84867906812 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: 2012 update on diagnosis, monitoring, and management
    • Jabbour E, Kantarjian H. Chronic myeloid leukemia: 2012 update on diagnosis, monitoring, and management. Am J Hematol. 2012; 87(11):1037-1045.
    • (2012) Am J Hematol. , vol.87 , Issue.11 , pp. 1037-1045
    • Jabbour, E.1    Kantarjian, H.2
  • 6
    • 84883277440 scopus 로고    scopus 로고
    • National Cancer Institute [homepage on the Internet], Available from:, Accessed July 23, 2013
    • National Cancer Institute [homepage on the Internet]. Chronic Myelogenous Leukemia Treatment. Available from: http://www.cancer.gov. Accessed July 23, 2013.
    • Chronic Myelogenous Leukemia Treatment
  • 7
    • 84883277816 scopus 로고    scopus 로고
    • New York, NY: Pfizer Labs
    • Bosulif [package insert]. New York, NY: Pfizer Labs; 2012.
    • (2012) Bosulif [package insert]
  • 8
    • 84883281056 scopus 로고    scopus 로고
    • Cambridge, MA: Ariad Pharmaceuticals
    • Iclusig [package insert]. Cambridge, MA: Ariad Pharmaceuticals; 2012.
    • (2012) Iclusig [package insert]
  • 9
    • 84883288489 scopus 로고    scopus 로고
    • National Cancer Institute [homepage on the Internet], Available from:, Accessed July 23, 2013
    • National Cancer Institute [homepage on the Internet]. Childhood Acute Lymphoblastic Leukemia Treatment. Available from: http://www.cancer.gov. Accessed July 23, 2013.
    • Childhood Acute Lymphoblastic Leukemia Treatment
  • 10
    • 84883288489 scopus 로고    scopus 로고
    • National Cancer Institute [homepage on the Internet], Available from:, Accessed July 23, 2013
    • National Cancer Institute [homepage on the Internet]. Adult Acute Lymphoblastic Leukemia Treatment. Available from: http://www.cancer.gov. Accessed July 23, 2013.
    • Adult Acute Lymphoblastic Leukemia Treatment
  • 11
    • 0023874066 scopus 로고
    • Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults
    • Hoelzer D, Thiel E, Löffler H, et al. Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults. Blood. 1988;71(1):123-131.
    • (1988) Blood. , vol.71 , Issue.1 , pp. 123-131
    • Hoelzer, D.1    Thiel, E.2    Löffler, H.3
  • 12
    • 0023937477 scopus 로고
    • A cause-specific hazard rate analysis of prognostic factors among 199 adults with acute lymphoblastic leukemia: The Memorial Hospital experience since 1969
    • Gaynor J, Chapman D, Little C, et al. A cause-specific hazard rate analysis of prognostic factors among 199 adults with acute lymphoblastic leukemia: the Memorial Hospital experience since 1969. J Clin Oncol. 1988;6(6):1014-1030.
    • (1988) J Clin Oncol. , vol.6 , Issue.6 , pp. 1014-1030
    • Gaynor, J.1    Chapman, D.2    Little, C.3
  • 13
    • 79958058440 scopus 로고    scopus 로고
    • Philadelphia chromosome-positive acute lymphoblastic leukemia in childhood
    • Koo HH. Philadelphia chromosome-positive acute lymphoblastic leukemia in childhood. Korean J Pediatr. 2011;54(3):106-110.
    • (2011) Korean J Pediatr. , vol.54 , Issue.3 , pp. 106-110
    • Koo, H.H.1
  • 14
    • 77950573400 scopus 로고    scopus 로고
    • Through the "gatekeeper door": Exploiting the active kinase conformation
    • Zuccotto F, Ardini E, Casale E, Angiolini M. Through the "gatekeeper door": exploiting the active kinase conformation. J Med Chem. 2010;53(7):2681-2694.
    • (2010) J Med Chem. , vol.53 , Issue.7 , pp. 2681-2694
    • Zuccotto, F.1    Ardini, E.2    Casale, E.3    Angiolini, M.4
  • 15
    • 78650159009 scopus 로고    scopus 로고
    • Structural Mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): Lessons for overcoming kinase inhibitor resistance
    • Zhou T, Commodore L, Huang WS, et al. Structural Mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance. Chem Biol Drug Des. 2011;77(1):1-11.
    • (2011) Chem Biol Drug Des. , vol.77 , Issue.1 , pp. 1-11
    • Zhou, T.1    Commodore, L.2    Huang, W.S.3
  • 16
    • 70350507997 scopus 로고    scopus 로고
    • AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
    • O'Hare T, Shakespeare WC, Zhu XT, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009;16:5 (401-412).
    • (2009) Cancer Cell. , vol.16 , Issue.5 , pp. 401-412
    • O'Hare, T.1    Shakespeare, W.C.2    Zhu, X.T.3
  • 17
    • 84870012939 scopus 로고    scopus 로고
    • Ponatinib in refractory Philadelphia chromosome-positive leukemias
    • Cortes JE, Kantarjian H, Shah NP, et al. Ponatinib in refractory Philadelphia chromosome-positive leukemias. N Engl J Med. 2012; 367(22):2075-2088.
    • (2012) N Engl J Med. , vol.367 , Issue.22 , pp. 2075-2088
    • Cortes, J.E.1    Kantarjian, H.2    Shah, N.P.3
  • 18
    • 84883271810 scopus 로고    scopus 로고
    • US Food and Drug Administration, Available December 21, 2012. Silver Spring, MD. Available from:, Accessed January 16, 2013
    • US Food and Drug Administration, Center for Drug Evaluation and Research Medical Review Iclusig® NDA 203469 Application. Available December 21, 2012. Silver Spring, MD. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203469Orig1s000MedR.pdf. Accessed January 16, 2013.
    • Center for Drug Evaluation and Research Medical Review Iclusig® NDA 203469 Application
  • 20
    • 33646783722 scopus 로고    scopus 로고
    • National Cancer Institute, Bethesda, MD: National Cancer Institute, Available from:, Accessed April 9, 2013
    • National Cancer Institute. Common Terminology Criteria for Adverse Events v3.0. Bethesda, MD: National Cancer Institute; 2006. Available from: http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcaev3.pdf. Accessed April 9, 2013.
    • (2006) Common Terminology Criteria for Adverse Events v3.0
  • 22
    • 84883281144 scopus 로고    scopus 로고
    • Ariad Pharmacetuicals
    • Available from:, Accessed April 24, 2013
    • Ariad Pharmacetuicals. Ariad Pipeline. Available from: http://www.ariad.com/pipeline. Accessed April 24, 2013.
    • Ariad Pipeline
  • 23
    • 84873570654 scopus 로고    scopus 로고
    • Ponatinib suppresses the development of myeloid and lymphoid malignanies associated with FGFR1 abnormalities
    • Ren M, Qin H, Ren R, Cowell JK. Ponatinib suppresses the development of myeloid and lymphoid malignanies associated with FGFR1 abnormalities. Leukemia. 2013;27(1):32-40.
    • (2013) Leukemia. , vol.27 , Issue.1 , pp. 32-40
    • Ren, M.1    Qin, H.2    Ren, R.3    Cowell, J.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.