Alpha-Melanocyte Stimulating Hormone (α-MSH) Is a Post-Caspase Suppressor of Apoptosis in RAW 264.7 Macrophages

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Taylor, Andrew W ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; CASPASE 3; CASPASE 8; CASPASE 9; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; MACROPHAGE; MACROPHAGE ACTIVATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NICK END LABELING; PROTEIN BINDING; PROTEIN EXPRESSION; RETINA CELL; RETINAL PIGMENT EPITHELIAL CELL;

ALPHA-MSH; ANIMALS; ANNEXIN A5; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELL CULTURE TECHNIQUES; CELL LINE; ENZYME ACTIVATION; IN SITU NICK-END LABELING; MACROPHAGES; MICE; MITOCHONDRIA; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 84883238786     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074488     Document Type: Article

References (32)

1. Chakraborty AK, Funasaka Y, Slominski A, Ermak G, Hwang J, et al. (1996) Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B. Biochim Biophys Acta 1313: 130-138. doi:10.1016/0167-4889(96)00063-8. PubMed: 8781560.
2. D'Agostino G, Diano S, (2010) Alpha-melanocyte stimulating hormone: production and degradation. J Mol Med 88: 1195-1201. doi:10.1007/s00109-010-0651-0. PubMed: 20617297.
3. Rajora N, Ceriani G, Catania A, Star RA, Murphy MT, et al. (1996) alpha-MSH production, receptors, and influence on neopterin in a human monocyte/macrophage cell line. J Leukoc Biol 59: 248-253. PubMed: 8603997.
4. Lau CH, Taylor AW, (2009) The immune privileged retina mediates an alternative activation of J774A.1 cells. Ocul Immunol Inflamm 17: 380-389. doi:10.3109/09273940903118642. PubMed: 20001256.
5. Tung YC, Piper SJ, Yeung D, O'Rahilly S, Coll AP, (2006) A comparative study of the central effects of specific POMC-derived melanocortin peptides on food intake and body weight in Pomc null mice. Endocrinology.
6. Li D, Taylor AW, (2008) Diminishment of alpha-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264.7 macrophages. J Leukoc Biol 84: 191-198. doi:10.1189/jlb.0707463. PubMed: 18388300.
7. Yoon SW, Goh SH, Chun JS, Cho EW, Lee MK, et al. (2003) alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor kappa B signaling pathways. J Biol Chem 278: 32914-32920. doi:10.1074/jbc.M302444200. PubMed: 12816950.
8. Lam CW, Perretti M, Getting SJ, (2006) Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides 27: 404-412. doi:10.1016/j.peptides.2005.01.031. PubMed: 16293345.
9. Luger TA, Kalden D, Scholzen TE, Brzoska T, (1999) alpha-melanocyte-stimulating hormone as a mediator of tolerance induction. Pathobiology 67: 318-321. doi:10.1159/000028089. PubMed: 10725812.
10. Taylor AW, Streilein JW, Cousins SW, (1994) Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. Neuroimmunomodulation 1: 188-194. doi:10.1159/000097167. PubMed: 7489333.
11. Lee DJ, Taylor AW, (2011) Following EAU-recovery there is an associated MC5r-dependent APC induction of regulatory immunity in the spleen. Invest Ophthalmol Vis Sci.
12. Grabbe S, Bhardwaj RS, Mahnke K, Simon MM, Schwarz T, et al. (1996) alpha-Melanocyte-stimulating hormone induces hapten-specific tolerance in mice. J Immunol 156: 473-478. PubMed: 8543796.
13. Taylor AW, (2007) Ocular immunosuppressive microenvironment. Chem Immunol Allergy 92: 71-85. PubMed: 17264484.
14. Taylor AW, Streilein JW, Cousins SW, (1992) Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor. Curr Eye Res 11: 1199-1206. doi:10.3109/02713689208999545. PubMed: 1490338.
15. Nishida T, Taylor AW, (1999) Specific aqueous humor factors induce activation of regulatory T cells. Invest Ophthalmol Vis Sci 40: 2268-2274. PubMed: 10476792.
16. Kawanaka N, Taylor AW, (2010) Localized retinal neuropeptide regulation of macrophage and microglial cell functionality. J Neuroimmunol, 232: 17-25. PubMed: 20965575.
17. Böhm M, Wolff I, Scholzen TE, Robinson SJ, Healy E, et al. (2004) Alpha-melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage. J Biol Chem, 280: 5795-802. PubMed: 15569680.
18. Lee SY, Jo SK, Cho WY, Kim HK, Won NH, (2004) The effect of alpha-melanocyte-stimulating hormone on renal tubular cell apoptosis and tubulointerstitial fibrosis in cyclosporine A nephrotoxicity. Transplantation 78: 1756-1764. doi:10.1097/01.TP.0000144332.44435.AB. PubMed: 15614148.
19. Chai B, Li JY, Zhang W, Newman E, Ammori J, et al. (2006) Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Peptides 27: 2846-2857. doi:10.1016/j.peptides.2006.05.005. PubMed: 16806584.
20. Caruso C, Durand D, Schiöth HB, Rey R, Seilicovich A, et al. (2007) Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytes. Endocrinology 148: 4918-4926. doi:10.1210/en.2007-0366. PubMed: 17595227.
21. Chin BY, (1999) Transforming Growth Factor beta 1 Rescues Serum Deprivation-induced Apoptosis via the Mitogen-activated Protein Kinase (MAPK) Pathway in Macrophages. J Biol Chem 274: 11362-11368. doi:10.1074/jbc.274.16.11362. PubMed: 10196228.
22. Iida KT, (2002) Insulin Inhibits Apoptosis of Macrophage Cell Line, THP-1 Cells, via Phosphatidylinositol-3-Kinase-Dependent Pathway. Arterioscler Thromb Vasc Biol 22: 380-386. doi:10.1161/hq0302.105272. PubMed: 11884278.
23. Wei J, Sun Z, Chen Q, Gu J, (2006) Serum deprivation induced apoptosis in macrophage is mediated by autocrine secretion of type I IFNs. Apoptosis Int J Programmed Cell Death 11: 545-554. doi:10.1007/s10495-006-5146-7. PubMed: 16532277.
24. Lopez S, Jaramillo S, Varela LM, Ortega A, Bermudez B, et al. (2013) p38 MAPK Protects Human Monocytes from Postprandial Triglyceride-Rich Lipoprotein-Induced Toxicity. J Nutr, 143: 620-6. PubMed: 23486980.
25. Juo P, Kuo CJ, Reynolds SE, Konz RF, Raingeaud J, et al. (1997) Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Mol Cell Biol 17: 24-35. PubMed: 8972182.
26. Huang S, Jiang Y, Li Z, Nishida E, Mathias P, et al. (1997) Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity 6: 739-749. doi:10.1016/S1074-7613(00)80449-5. PubMed: 9208846.
27. Gumireddy K, Reddy CD, Swamy N, (2003) Mitogen-activated protein kinase pathway mediates DBP-maf-induced apoptosis in RAW 264.7 macrophages. J Cell Biochem 90: 87-96.
28. Taylor AW, (2005) The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages. J Neuroimmunol 162: 43-50. doi:10.1016/j.jneuroim.2005.01.008. PubMed: 15833358.
29. Lamkanfi M, Festjens N, Declercq W, Vanden Berghe T, Vandenabeele P, (2007) Caspases in cell survival, proliferation and differentiation. Cell Death Differ 14: 44-55. doi:10.1038/sj.cdd.4402047. PubMed: 17053807.
30. Su H, Bidère N, Zheng L, Cubre A, Sakai K, et al. (2005) Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science 307: 1465-1468. doi:10.1126/science.1104765. PubMed: 15746428.
31. Santambrogio L, Potolicchio I, Fessler SP, Wong SH, Raposo G, et al. (2005) Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cells. Nat Immunol 6: 1020-1028. doi:10.1038/ni1250. PubMed: 16170319.
32. Taylor AW, Lee DJ, (2011) The alpha-melanocyte stimulating hormone induces conversion of effector T cells into treg cells. J of Transplantation(2011): pp. 246856. PubMed: 21941624.