Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 8, 2013, Pages 5824-5828

  Nongpiur, Monisha E ^a   Wei, Xin ^a,b   Xu, Liang ^c   Perera, Shamira A ^a   Wu, Ren Yi ^a   Zheng, Yingfeng ^a   Li, Yang ^c   Wang, Ya Xing ^c   Cheng, Ching Yu ^a,d,e   Jonas, Jost B ^f   Wong, Tien Yin ^a,d,e   Vithana, Eranga N ^a,d   Aung, Tin ^a,d   Khor, Chiea Chuen ^a,d,e,g  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b Singapore Graduate Medical School   (Singapore)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f Department of Ophthalmology ^*  (Germany)

^g GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

Anterior segment OCT; Association; Genetic; Glaucoma; Quantitative trait

Indexed keywords

ADULT; AGED; ANTERIOR EYE CHAMBER DEPTH; ARTICLE; BIOMETRY; CLOSED ANGLE GLAUCOMA; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; EYE AXIS LENGTH; FEMALE; GENE LOCUS; GENETIC SUSCEPTIBILITY; GENOTYPE; GENOTYPING TECHNIQUE; HUMAN; MALE; PRIORITY JOURNAL; REFLECTOMETRY; SINGLE NUCLEOTIDE POLYMORPHISM;

ANTERIOR SEGMENT OCT; ASSOCIATION; GENETIC; GLAUCOMA; QUANTITATIVE TRAIT;

ADULT; AGED; AGED, 80 AND OVER; ANTERIOR CHAMBER; ASIAN CONTINENTAL ANCESTRY GROUP; AXIAL LENGTH, EYE; CARRIER PROTEINS; CHINA; COHORT STUDIES; COLLAGEN TYPE XI; CROSS-SECTIONAL STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLAUCOMA, ANGLE-CLOSURE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SINGAPORE;

EID: 84883223877     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-11901     Document Type: Article

References (34)

1. Foster PJ, Oen FT, Machin D, et al. The prevalence of glaucoma in Chinese residents of Singapore: a cross-sectional population survey of the Tanjong Pagar district. Arch Ophthalmol. 2000; 118:1105-1111.
2. Hu CN. An epidemiologic study of glaucoma in Shunyi County, Beijing [in Chinese]. Zhonghua Yan Ke Za Zhi. 1989;25:115-119.
3. Foster PJ, Johnson GJ. Glaucoma in China: how big is the problem? Br J Ophthalmol. 2001;85:1277-1282.
4. Foster PJ, Baasanhu J, Alsbirk PH, Munkhbayar D, Uranchimeg D, Johnson GJ. Glaucoma in Mongolia: a population-based survey in Hövsgöl Province, northern Mongolia. Arch Ophthalmol. 1996;114:1235-1241.
5. Dandona L, Dandona R, Mandal P, et al. Angle-closure glaucoma in an urban population in southern India. The Andhra Pradesh eye disease study. Ophthalmology. 2000;107: 1710-1716.
6. Vijaya L, George R, Arvind H, et al. Prevalence and causes of blindness in the rural population of the Chennai Glaucoma Study. Br J Ophthalmol. 2006;90:407-410.
7. Vithana EN, Khor CC, Qiao C, et al. Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2012;44:1142-1146.
8. Alsbirk PH. Primary angle-closure glaucoma. Oculometry, epidemiology, and genetics in a high risk population. Acta Ophthalmol Suppl. 1976;(127):5-31.
9. Lowe RF. Aetiology of the anatomical basis for primary angleclosure glaucoma. Biometrical comparisons between normal eyes and eyes with primary angle-closure glaucoma. Br J Ophthalmol. 1970;54:161-169.
10. Lavanya R, Wong TY, Friedman DS, et al. Determinants of angle closure in older Singaporeans. Arch Ophthalmol. 2008;126: 686-691.
11. Yip JL, Foster PJ. Ethnic differences in primary angle-closure glaucoma. Curr Opin Ophthalmol. 2006;17:175-180.
12. Sun X, Ji X, Zheng Y, Guo B. Primary chronic angle-closure glaucoma in Chinese-a clinical exploration of its pathogenesis and natural course. Yan Ke Xue Bao. 1994;10:176-185.
13. Lin YW, Wang TH, Hung PT. Biometric study of acute primary angle-closure glaucoma. J Formos Med Assoc. 1997;96:908-912.
14. Foong AW, Saw SM, Loo JL, et al. Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES). Ophthalmic Epidemiol. 2007;14:25-35.
15. Lavanya R, Jeganathan VS, Zheng Y, et al. Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians. Ophthalmic Epidemiol. 2009;16:325-336.
16. Xu L, Li Y, Zheng Y, Jonas JB. Associated factors for age related maculopathy in the adult population in China: the Beijing eye study. Br J Ophthalmol. 2006;90:1087-1090.
17. Yin G, Wang YX, Zheng ZY, Yang H, Xu L, Jonas JB; Beijing Eye Study Group. Ocular axial length and its associations in Chinese: the Beijing Eye Study. PLoS One. 2012;7:e43172.
18. Rohrer K, Frueh BE, Wälti R, Clemetson IA, Tappeiner C, Goldblum D. Comparison and evaluation of ocular biometry using a new noncontact optical low-coherence reflectometer. Ophthalmology. 2009;116:2087-2092.
19. Vithana EN, Aung T, Khor CC, et al. Collagen-related genes influence the glaucoma risk factor, central corneal thickness. Hum Mol Genet. 2011;20:649-658.
20. Cornes BK, Khor CC, Nongpiur ME, et al. Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations. Hum Mol Genet. 2012;21: 437-445.
21. Khor CC, Ramdas WD, Vithana EN, et al. Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. Hum Mol Genet. 2011;20: 1864-1872.
22. Lu Y, Vitart V, Burdon KP, et al. Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nat Genet. 2013;45:155-163.
23. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559-575.
24. Nongpiur ME, Ku JY, Aung T. Angle closure glaucoma: a mechanistic review. Curr Opin Ophthalmol. 2011;22:96-101.
25. Nongpiur ME, Sakata LM, Friedman DS, et al. Novel association of smaller anterior chamber width with angle closure in Singaporeans. Ophthalmology. 2010;117:1967-1973.
26. Wu RY, Nongpiur ME, He MG, et al. Association of narrow angles with anterior chamber area and volume measured with anterior-segment optical coherence tomography. Arch Ophthalmol. 2011;129:569-574.
27. Wang B, Sakata LM, Friedman DS, et al. Quantitative iris parameters and association with narrow angles. Ophthalmology. 2010;117:11-17.
28. Nongpiur ME, He M, Amerasinghe N, et al. Lens vault, thickness, and position in Chinese subjects with angle closure. Ophthalmology. 2011;118:474-479.
29. Quigley HA, Silver DM, Friedman DS, et al. Iris cross-sectional area decreases with pupil dilation and its dynamic behavior is a risk factor in angle closure. J Glaucoma. 2009;18:173-179.
30. Aptel F, Denis P. Optical coherence tomography quantitative analysis of iris volume changes after pharmacologic mydriasis. Ophthalmology. 2010;117:3-10.
31. Quigley HA, Friedman DS, Congdon NG. Possible mechanisms of primary angle-closure and malignant glaucoma. J Glaucoma. 2003;12:167-180.
32. Meng W, Mushika Y, Ichii T, Takeichi M. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell. 2008;135:948-959.
33. Pulimeno P, Bauer C, Stutz J, Citi S. PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin. PLoS One. 2010;5:e12207.
34. Sng CC, Foo LL, Cheng CY, et al. Determinants of anterior chamber depth: the Singapore Chinese Eye Study. Ophthalmology. 2012;119:1143-1450.