Dihydrotanshinone induces p53-independent but ROS-dependent apoptosis in colon cancer cells

Life Sciences

Volumn 93, Issue 8, 2013, Pages 344-351

  Wang, L ^a   Yeung, J H K ^a   Hu, T ^a   Lee, W Y ^a   Lu, L ^a   Zhang, L ^a   Shen, J ^a   Chan, R L Y ^a   Wu, W K K ^b   Cho, C H ^a  

^a Prince of Wales Hospital   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Colon cancer; Dihydrotanshinone; p53; ROS

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETYLCYSTEINE; CATALASE; CRYPTOTANSHINONE; DIHYDROTANSHINONE; MILTIRONE; MITOCHONDRIAL PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TANSHINONE; TANSHINONE I; TANSHINONE IIA; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DRUG STRUCTURE; FIBROBLAST; GENOTYPE; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL DNA DISORDER; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; WESTERN BLOTTING;

APOPTOSIS; COLON CANCER; DIHYDROTANSHINONE; P53; ROS;

APOPTOSIS; BLOTTING, WESTERN; CACO-2 CELLS; CELL SURVIVAL; COLONIC NEOPLASMS; FLOW CYTOMETRY; FREE RADICAL SCAVENGERS; HCT116 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, CONFOCAL; OXIDATIVE PHOSPHORYLATION; PHENANTHRENES; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84883218642     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.07.007     Document Type: Article

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