Double versus standard loading dose of ticagrelor: Onset of antiplatelet action in patients with stemi undergoing primary PCI

Journal of the American College of Cardiology

Volumn 62, Issue 10, 2013, Pages 940-941

  Alexopoulos, Dimitrios ^a   Gkizas, Vassilios ^a   Patsilinakos, Sotirios ^b   Xanthopoulou, Ioanna ^a   Angelidis, Christos ^c   Anthopoulos, Prodromos ^d   Makris, George ^a   Perperis, Angelos ^a   Karanikas, Stavros ^b   Koutsogiannis, Nikolaos ^a   Davlouros, Periklis ^a   Deftereos, Spyridon ^c   Chiladakis, John ^a   Hahalis, George ^a  

^a UNIVERSITY HOSPITAL OF PATRAS   (Greece)

^b IASO GENERAL HOSPITAL   (Greece)

^c G GENNIMATAS GENERAL HOSPITAL   (Greece)

^d EVANGELISMOS HOSPITAL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; TICAGRELOR;

ADULT; AGED; ANTICOAGULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; LETTER; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PATIENT ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PLATELET REACTIVITY; PRIORITY JOURNAL; PROPENSITY SCORE; PROSPECTIVE STUDY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; THROMBOCYTE FUNCTION;

ADENOSINE; AGED; BLOOD PLATELETS; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PLATELET AGGREGATION INHIBITORS; PROSPECTIVE STUDIES; PURINERGIC P2Y RECEPTOR ANTAGONISTS; TREATMENT OUTCOME;

EID: 84883211765     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.05.021     Document Type: Letter

References (5)

1. P.A. Gurbel, K.P. Bliden, and K. Butler Randomized double-blind assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease: the ONSET/OFFSET Study Circulation 120 2009 2577 2585
2. M.A. Giorgi, H. Cohen Arazi, C.D. Gonzalez, and G. Di Girolamo Beyond efficacy: pharmacokinetic differences between clopidogrel, prasugrel and ticagrelor Expert Opin Pharmacother 12 2011 1285 1295
3. R.F. Storey, D.J. Angiolillo, and S.B. Patil Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (PLATelet inhibition and patient Outcomes) PLATELET substudy J Am Coll Cardiol 56 2010 1456 1462
4. D. Alexopoulos, I. Xanthopoulou, and V. Gkizas Randomized assessment of ticagrelor versus prasugrel antiplatelet effects in patients with ST elevation myocardial infarction Circ Cardiovasc Interv 5 2012 797 804
5. K. Butler, and R. Teng Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers Br J Clin Pharmacol 70 2010 65 77