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Volumn 12, Issue 8, 2011, Pages 1285-1295

Beyond efficacy: Pharmacokinetic differences between clopidogrel, prasugrel and ticagrelor

Author keywords

antiplatelet agents; clopidogrel; pharmacodynamic; pharmacokinetics; prasugrel; ticagrelor

Indexed keywords

CLOPIDOGREL; CYTOCHROME P450; PRASUGREL; TICAGRELOR;

EID: 79954624013     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.2011.550573     Document Type: Review
Times cited : (42)

References (65)
  • 3
    • 70450199115 scopus 로고    scopus 로고
    • 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention
    • Kushner FG, Hand M, Smith SC Jr, et al.2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update): a report of the American college of cardiology foundation/American heart association task force on practice guidelines.J Am Coll Cardiol 2009;54:2205-41
    • (2009) J Am Coll Cardiol , vol.54 , pp. 2205-41
    • Kushner, F.G.1    Hand, M.2
  • 4
    • 79955876128 scopus 로고    scopus 로고
    • The task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)
    • doi:10.1093/eurheartj/ehq277 [Last accessed 31 August 2010]
    • The task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS).Eur Heart J 2010, doi:10.1093/eurheartj/ehq277.Available from: http://www.escardio.org/guidelines-surveys/esc-guidelines/Guidelines Documents/guidelines-revasc-FT.pdf [Last accessed 31 August 2010].
    • (2010) Eur Heart J
  • 5
    • 77953753809 scopus 로고    scopus 로고
    • Clinical implications of clopidogrel non-response in cardiovascular patients: A systematic review and meta-analysis
    • Combescure C, Fontana P, Mallouk N, et al.Clinical implications of clopidogrel non-response in cardiovascular patients: a systematic review and meta-analysis.J Thromb Haemost 2010;8:923-33
    • (2010) J Thromb Haemost , vol.8 , pp. 923-33
    • Combescure, C.1    Fontana, P.2    Mallouk, N.3
  • 6
    • 77953911457 scopus 로고    scopus 로고
    • Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate
    • Bonello L, Tantry US, Marcucci R, et al.Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate.J Am Cardiol 2010;56:919-33
    • (2010) J Am Cardiol , vol.56 , pp. 919-33
    • Bonello, L.1    Tantry, U.S.2    Marcucci, R.3
  • 7
    • 19444376971 scopus 로고    scopus 로고
    • Drug metabolism and variability among patients in drug response
    • Wilkinson GR.Drug metabolism and variability among patients in drug response.N Engl J Med 2005;352:2211-21
    • (2005) N Engl J Med , vol.352 , pp. 2211-21
    • Wilkinson, G.R.1
  • 9
    • 67449103847 scopus 로고    scopus 로고
    • Possibility of a rebound phenomenon following antiplatelet therapy withdrawal: A look at the clinical and pharmacological evidence
    • Lordkipanidze M, Diodati JG, Pharand C.Possibility of a rebound phenomenon following antiplatelet therapy withdrawal: a look at the clinical and pharmacological evidence.Pharmacol Ther 2009;123:178-86
    • (2009) Pharmacol Ther , vol.123 , pp. 178-86
    • Lordkipanidze, M.1    Diodati, J.G.2    Pharand, C.3
  • 11
    • 77956566371 scopus 로고    scopus 로고
    • Nonresponders to clopidogrel: Pharmacokinetics and interactions involved
    • Giorgi MA, Gonzalez CD, Di Girolamo.Nonresponders to clopidogrel: pharmacokinetics and interactions involved.Expert Opin Pharmacother 2010;11:2391-403
    • (2010) Expert Opin Pharmacother , vol.11 , pp. 2391-403
    • Giorgi, M.A.1    Girolamo, C.D.2
  • 12
    • 47649116687 scopus 로고    scopus 로고
    • Pharmacology of novel antiplatelet inhibitors
    • Angiolillo DJ, Capranzano P.Pharmacology of novel antiplatelet inhibitors.Am Heart J 2008;156:S10-15
    • (2008) Am Heart J , vol.156
    • Angiolillo, D.J.1    Capranzano, P.2
  • 13
    • 37849002889 scopus 로고    scopus 로고
    • Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
    • Wallentin L, Varenhorst C, James S, et al.Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease.Eur Heart J 2008;29:21-30
    • (2008) Eur Heart J , vol.29 , pp. 21-30
    • Wallentin, L.1    Varenhorst, C.2    James, S.3
  • 16
    • 50249184573 scopus 로고    scopus 로고
    • Effect of ranitidine on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel
    • Small DS, Farid NA, Li YG, et al.Effect of ranitidine on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel.Curr Med Res Opin 2008;24:2251-7
    • (2008) Curr Med Res Opin , vol.24 , pp. 2251-7
    • Small, D.S.1    Farid, N.A.2    Li, Y.G.3
  • 17
    • 77954468084 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, tolerability, and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y12 receptor antagonist, in healthy subjects
    • Teng R, Butler K.Pharmacokinetics, pharmacodynamics, tolerability, and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y12 receptor antagonist, in healthy subjects.Eur J Clin Pharmacol 2010;66:487-96
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 487-96
    • Teng, R.1    Butler, K.2
  • 18
    • 57149084688 scopus 로고    scopus 로고
    • Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects
    • Farid NA, Small DS, Payne CD, et al.Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects.Pharmacotherapy 2008;28:1483-94
    • (2008) Pharmacotherapy , vol.28 , pp. 1483-94
    • Farid, N.A.1    Small, D.S.2    Payne, C.D.3
  • 19
    • 75749102996 scopus 로고    scopus 로고
    • Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans
    • Farid NA, Kurihara A, Wrighton SA, et al.Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans.J Clin Pharmacol 2010;50:126-42
    • (2010) J Clin Pharmacol , vol.50 , pp. 126-42
    • Farid, N.A.1    Kurihara, A.2    Wrighton, S.A.3
  • 20
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • Simon T, Verstuyft C, Mary-Krause M, et al.Genetic determinants of response to clopidogrel and cardiovascular events.N Engl J Med 2009;360:363-75
    • (2009) N Engl J Med , vol.360 , pp. 363-75
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 21
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • doi:10.1016/s0140-6736(10) 61274-3 [Last accessed 22 November 2010]
    • Mega JL, Close SL, Wiviott SD, et al.Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.Lancet 2010; doi:10.1016/s0140-6736(10) 61274-3.Avalilable from: www.thelancet.com [Last accessed 22 November 2010]
    • (2010) Lancet
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 22
  • 23
    • 66349133650 scopus 로고    scopus 로고
    • Cytochrome P450 genetic polymorphism and the response to prasugrel.Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes
    • Mega JL, Close SL, Wiviott SD, et al.Cytochrome P450 genetic polymorphism and the response to prasugrel.Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes.Circulation 2009;119:2553-60
    • (2009) Circulation , vol.119 , pp. 2553-60
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 24
    • 77956607147 scopus 로고    scopus 로고
    • COGENT: A prospective, randomized, placebo controlled trial of omeprazole in patients receiving aspirin and clopidogrel
    • 24 September San Francisco, CA, USA
    • Bahtt DL.COGENT: a prospective, randomized, placebo controlled trial of omeprazole in patients receiving aspirin and clopidogrel.Presented at Transcatheter Cardiovascular Therapeutics, 24 September 2009, San Francisco, CA, USA
    • (2009) Transcatheter Cardiovascular Therapeutics
    • Bahtt, D.L.1
  • 25
    • 33751171573 scopus 로고    scopus 로고
    • Antiplatelet agents aspirin and clopidogrel are hydrolized by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol
    • Tang M, Mukundan M, Yang J, et al.Antiplatelet agents aspirin and clopidogrel are hydrolized by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol.J Pharamacol Exp Ther 2006;319:1467-76
    • (2006) J Pharamacol Exp Ther , vol.319 , pp. 1467-76
    • Tang, M.1    Mukundan, M.2    Yang, J.3
  • 26
    • 73149119363 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
    • Kazui M, Nishiya Y, Ishizuka T, et al.Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.Drug Metab Dispos 2010;38:92-9
    • (2010) Drug Metab Dispos , vol.38 , pp. 92-9
    • Kazui, M.1    Nishiya, Y.2    Ishizuka, T.3
  • 27
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • DOI 10.1182/blood-2006-04-013052
    • Hulot JS, Bura A, Villard E, et al.Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects.Blood 2006;108:2244-7 (Pubitemid 44497506)
    • (2006) Blood , vol.108 , Issue.7 , pp. 2244-2247
    • Hulot, J.-S.1    Bura, A.2    Villard, E.3    Azizi, M.4    Remones, V.5    Goyenvalle, C.6    Aiach, M.7    Lechat, P.8    Gaussem, P.9
  • 28
    • 38449103046 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10+12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients
    • DOI 10.1097/FPC.0b013e3282f1b2be, PII 0121301120071200000006
    • Giusti B, Gori AM, Marcucci R, et al.Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 +12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients.Phamacogenet Genomics 2007;17:1057-64 (Pubitemid 351339490)
    • (2007) Pharmacogenetics and Genomics , vol.17 , Issue.12 , pp. 1057-1064
    • Giusti, B.1    Gori, A.M.2    Marcucci, R.3    Saracini, C.4    Sestini, I.5    Paniccia, R.6    Valente, S.7    Antoniucci, D.8    Abbate, R.9    Gensini, G.F.10
  • 29
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • Shuldiner AR, OConnel JR, Bliden KP, et al.Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.JAMA 2009;302:849-58
    • (2009) JAMA , vol.302 , pp. 849-58
    • Shuldiner, A.R.1    Oconnel, J.R.2    Bliden, K.P.3
  • 31
    • 77955638355 scopus 로고    scopus 로고
    • ACC/AHA clopidogrel clinical alert: Approaches to the FDA Boxed Warning: A report of the American college of cardiology foundation task force on clinical expert consensus eocuments and the American heart association
    • Holmes DR, Dehmer GJ, Kaul S, et al.ACC/AHA clopidogrel clinical alert: approaches to the FDA Boxed Warning: a report of the American college of cardiology foundation task force on clinical expert consensus eocuments and the American heart association.J Am Coll Cardiol 2010;56:321-41
    • (2010) J Am Coll Cardiol , vol.56 , pp. 321-41
    • Holmes, D.R.1    Dehmer, G.J.2    Kaul, S.3
  • 32
    • 58249135635 scopus 로고    scopus 로고
    • Cytochrome P450 C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: A cohort study
    • Collet JP, Hullot JS, Pena A, et al.Cytochrome P450 C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study.Lancet 2009;373:309-17
    • (2009) Lancet , vol.373 , pp. 309-17
    • Collet, J.P.1    Hullot, J.S.2    Pena, A.3
  • 33
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of associated with aspirin.The randomized, double-blind, OCLA (Omeprazole Clopidogrel Aspirin) study
    • Gilard M, Arnaud B, Cornily JC, et al.Influence of omeprazole on the antiplatelet action of associated with aspirin.The randomized, double-blind, OCLA (Omeprazole Clopidogrel Aspirin) study.J Am Coll Cardiol 2008;51:256-60
    • (2008) J Am Coll Cardiol , vol.51 , pp. 256-60
    • Gilard, M.1    Arnaud, B.2    Cornily, J.C.3
  • 34
    • 70249139788 scopus 로고    scopus 로고
    • Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: An analysis of two randomized trials
    • ODonoghue ML, Braunwald E, Antman EM, et al.Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomized trials.Lancet 2009;374:989-97
    • (2009) Lancet , vol.374 , pp. 989-97
    • Odonoghue, M.L.1    Braunwald, E.2    Antman, E.M.3
  • 35
    • 62649164844 scopus 로고    scopus 로고
    • A population-based study of the drug interaction between proton-pump inhibitors and clopidogrel
    • Juurlink DN, Gomes T, Ko DT, et al.A population-based study of the drug interaction between proton-pump inhibitors and clopidogrel.CMAJ 2009;180:713-18
    • (2009) CMAJ , vol.180 , pp. 713-18
    • Juurlink, D.N.1    Gomes, T.2    Ko, D.T.3
  • 36
    • 77950895115 scopus 로고    scopus 로고
    • Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: A cohort study
    • Ray WA, Murray KT, Griffin MR, et al.Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study.Ann Intern Med 2010;152:393-5
    • (2010) Ann Intern Med , vol.152 , pp. 393-5
    • Ray, W.A.1    Murray, K.T.2    Griffin, M.R.3
  • 37
    • 70249144272 scopus 로고    scopus 로고
    • Risk of combining PPIs with thienopyridines: Fact or fiction?
    • Sibbing D, Kastrati A.Risk of combining PPIs with thienopyridines: fact or fiction? Lancet 2009;374:952-4
    • (2009) Lancet , vol.374 , pp. 952-4
    • Sibbing, D.1    Kastrati, A.2
  • 40
    • 78649696637 scopus 로고    scopus 로고
    • ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: A focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American college of cardiology foundation task force
    • Abraham NS, Hlatky MA, Antman EM, et al.ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American college of cardiology foundation task force.J Am Coll Cardiol 2010:56:2051-66
    • (2010) J Am Coll Cardiol , vol.56 , pp. 2051-66
    • Abraham, N.S.1    Hlatky, M.A.2    Antman, E.M.3
  • 44
    • 79955863594 scopus 로고    scopus 로고
    • [Last accessed 20 November 2010]
    • Prasugrel label information.Available from: www.dailymed.nlm.nih.gov/ dailymed/getfile.cfm? id12285&type=pdf&name=sfe91c18- c44b-48d7-1142-9668ae3df0c6 [Last accessed 20 November 2010]
    • Prasugrel Label Information
  • 45
    • 33845451677 scopus 로고    scopus 로고
    • A comparison of prasugrel and clopidogrel loading doses on platelet function: Magnitude of platelet inhibition is related to active metabolite formation
    • Brandt JT, Payne CD, Wiviott SD, et al.A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation.Am Heart J 2007;153:66, e9-e16
    • (2007) Am Heart J , vol.153 , Issue.66
    • Brandt, J.T.1    Payne, C.D.2    Wiviott, S.D.3
  • 46
    • 33645105318 scopus 로고    scopus 로고
    • Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450
    • Rehmel JL, Eckstein JA, Farid NA, et al.Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450.Drug Metab Dispos 2006;34:600-7
    • (2006) Drug Metab Dispos , vol.34 , pp. 600-7
    • Rehmel, J.L.1    Eckstein, J.A.2    Farid, N.A.3
  • 49
    • 57149084688 scopus 로고    scopus 로고
    • Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects
    • Farid NA, Small DS, Payne CD, et al.Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects.Pharmacotherapy 2008;28:1483-94
    • (2008) Pharmacotherapy , vol.28 , pp. 1483-94
    • Farid, N.A.1    Small, D.S.2    Payne, C.D.3
  • 50
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • doi:10.1016/S0140-6736(10)61274-3 [Last accessed 29 August 2010]
    • Wallentin L, James S, Storey RF, et al.Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial.Lancet 2010, doi:10.1016/S0140-6736(10)61274-3.Available from: www.thelancet.com [Last accessed 29 August 2010]
    • (2010) Lancet
    • Wallentin, L.1    James, S.2    Storey, R.F.3
  • 51
    • 77955992168 scopus 로고    scopus 로고
    • Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects
    • Teng R, Oliver S, Hayes MA, et al.Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects.Drug Metab Dispos 2010;38:1514-21
    • (2010) Drug Metab Dispos , vol.38 , pp. 1514-21
    • Teng, R.1    Oliver, S.2    Hayes, M.A.3
  • 52
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin L, Becker R, Budaj A, et al.Ticagrelor versus clopidogrel in patients with acute coronary syndromes.N Engl J Med 2009;361:1045-57
    • (2009) N Engl J Med , vol.361 , pp. 1045-57
    • Wallentin, L.1    Becker, R.2    Budaj, A.3
  • 53
    • 73949112820 scopus 로고    scopus 로고
    • Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: The ONSET/OFFSET study
    • Gurbel PA, Bliden KP, Butler K, et al.Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study.Circulation 2009;120:2577-85
    • (2009) Circulation , vol.120 , pp. 2577-85
    • Gurbel, P.A.1    Bliden, K.P.2    Butler, K.3
  • 54
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S, et al.Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin.Eur Heart J 2006;27:1038-47
    • (2006) Eur Heart J , vol.27 , pp. 1038-47
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3
  • 55
    • 77953498801 scopus 로고    scopus 로고
    • Pharmacokinetics pharmacodynamics safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers
    • Butler K, Teng R.Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers.Br J Clin Pharmacol 2010;70:65-77
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 65-77
    • Butler, K.1    Teng, R.2
  • 57
    • 77953497679 scopus 로고    scopus 로고
    • Triple antiplatelet therapy for preventing vascular events: A systematic review and meta-analysis
    • Geeganage C, Wilcox R, Bath PM.Triple antiplatelet therapy for preventing vascular events: a systematic review and meta-analysis.BMC Med 2010;8:36
    • (2010) BMC Med , vol.8 , pp. 36
    • Geeganage, C.1    Wilcox, R.2    Bath, P.M.3
  • 59
    • 33947187284 scopus 로고    scopus 로고
    • Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial investigators
    • Stone GW, White HD, Ohman EM, et al.Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial investigators.Lancet 2007;369:907-19
    • (2007) Lancet , vol.369 , pp. 907-19
    • Stone, G.W.1    White, H.D.2    Ohman, E.M.3
  • 60
    • 77956290748 scopus 로고    scopus 로고
    • Dose comparisons of clopidogrel and aspirin in acute coronary syndromes
    • The CURRENT-OASIS 7 Investigators
    • The CURRENT-OASIS 7 Investigators.Dose comparisons of clopidogrel and aspirin in acute coronary syndromes.N Engl J Med 2010;363:930-42
    • (2010) N Engl J Med , vol.363 , pp. 930-42
  • 61
    • 77958005516 scopus 로고    scopus 로고
    • Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): A randomised factorial trial
    • doi:10.1016/S0140-6736(10) 61088-4 [Last accessed 2 September 2010]
    • Mehta SR, Tanguay JF, Eikelboom JW, et al.Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial.Lancet 2010, doi:10.1016/S0140-6736(10) 61088-4.Available from: www.thelancet.com [Last accessed 2 September 2010]
    • (2010) Lancet
    • Mehta, S.R.1    Tanguay, J.F.2    Eikelboom, J.W.3
  • 62
    • 65549123030 scopus 로고    scopus 로고
    • Baseline risk of major bleeding in non-ST-elevation myocardial infarction: The CRUSADE (Can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines) bleeding score
    • Subherwal S, Bach RG, Chen AY, et al.Baseline risk of major bleeding in non-ST-elevation myocardial infarction: the CRUSADE (Can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines) bleeding score.Circulation 2009;119:1873-82
    • (2009) Circulation , vol.119 , pp. 1873-82
    • Subherwal, S.1    Bach, R.G.2    Chen, A.Y.3
  • 63
    • 55649106157 scopus 로고    scopus 로고
    • Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery
    • Berger JS, Fye CB, Harshaw Q, et al.Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery.J Am Coll Cardiol 2008;52:1693-701
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1693-701
    • Berger, J.S.1    Fye, C.B.2    Harshaw, Q.3
  • 65
    • 0032813891 scopus 로고    scopus 로고
    • Pharmacokinetic profile of 14C-labeled clopidogrel
    • Lins R, Broekhuysen J, Necciari J, et al.Pharmacokinetic profile of 14C-labeled clopidogrel.Semin Thromb Hemost 1999;25(Suppl 2):29-33
    • (1999) Semin Thromb Hemost , vol.25 , Issue.SUPPL. 2 , pp. 29-33
    • Lins, R.1    Broekhuysen, J.2    Necciari, J.3


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