Metformin-induced mixed hepatocellular and cholestatic hepatic injury: Case report and literature review

International Journal of General Medicine

Volumn 6, Issue , 2013, Pages 703-706

  Saadi, Tarek ^a,b   Waterman, Matti ^a,b,c   Yassin, Heba ^b   Baruch, Yaacov ^a,c  

^a Liver Unit   (Israel)

^b Technion Israel Institute of Technology ^*  (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Cholestasis; Hepatocellular liver injury; Hepatotoxicity; Metformin

Indexed keywords

ACETYLSALICYLIC ACID; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMLODIPINE; AMOXICILLIN PLUS CLAVULANIC ACID; ASPARTATE AMINOTRANSFERASE; ATENOLOL; BILIRUBIN; C REACTIVE PROTEIN; CANDESARTAN; GAMMA GLUTAMYLTRANSFERASE; HYDROCHLOROTHIAZIDE; METFORMIN; PRAVASTATIN;

ABDOMINAL PAIN; ACUTE HEPATITIS; AGED; ANOREXIA; CASE REPORT; CHOLESTASIS; DIARRHEA; DIVERTICULOSIS; DRUG WITHDRAWAL; FATIGUE; GOUT; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; JAUNDICE; LIVER CELL DAMAGE; MALE; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; OBSTRUCTIVE JAUNDICE; PAROTITIS; PRURITUS; REVIEW; SYSTEMATIC REVIEW; VOMITING;

EID: 84883197543     PISSN: None     EISSN: 11787074     Source Type: Journal    
DOI: 10.2147/IJGM.S49657     Document Type: Review

References (19)

1. Aksay E, Yanturali S, Bayram B, Hocaoglu N, Kiyan S. A rare side effect of metformin: metformin-induced hepatotoxicity. Turkish Journal of Medical Sciences. 2007;37(3):173-175.
2. Kirpichnikov D, McFarlane SI, Sowers JR. Metformin: an update. Ann Intern Med. 2002;137:25-33.
3. [No authors listed]. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352:854-865.
4. Glucophage (metformin hydrochloride tablets). Prescribing information. Princeton, NJ: Bristol-Meyers Squibb; 1995.
5. Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med. 1995;333:550-554.
6. Deutsch M, Kountouras D, Dourakis SP. Metformin hepatotoxicity. Ann Intern Med. 2004;140(5):W25-W26.
7. Carrascosa M, Pascual F, Aresti S. Acarbose-induced acute severe hepatotoxicity. Lancet. 1997;349:698-699.
8. Dourakis SP, Tzemanakis E, Sinani C, Kafiri G, Hadziyannis SJ. Gliclazide-induced acute hepatitis. Eur J Gastroenterol Hepatol. 2000;12:119-121.
9. Chitturi S, George J. Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs. Semin Liver Dis. 2002;22:169-183.
10. Babich MM, Pike I, Shiffman ML. Metformin-induced acute hepatitis. Am J Med. 1998;104:490-492.
11. Desilets DJ, Shorr AF, Moran KA, Holtzmuller KC. Cholestatic jaundice associated with the use of metformin. Am J Gastroenterol. 2001;96:2257-2258.
12. Hussaini SH, O'Brien CS, Despott EJ, Dalton HR. Antibiotic therapy: a major cause of drug-induced jaundice in southwest England. Eur J Gastroenterol Hepatol. 2007;19(1):15-20.
13. Lucena MI, Andrade RJ, Fernández MC, etal; Spanish Group for the Study of Drug-Induced Liver Disease (Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos (GEHAM). Determinants of the clinical expression of amoxicillin-clavulanate hepatotoxicity: a prospective series from Spain. Hepatology. 2006;44(4):850-856.
14. Maria V, Victorino R. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology 1997;26: 664-669.
15. Naranjo CA, Busto U, Sellers EM, etal. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30: 239-245.
16. Sirtori CR, Franceschini G, Galli-Kienle M, etal. Disposition of metformin (N, N-dimethylbiguanide) in man. Clin Pharmacol Ther. 1978;24:683-693.
17. Nammour F, Fayad N, Peikin S. Metformin-induced cholestatic hepatitis. Endocr Pract. 2003;9(4):307-309.
18. Kutoh E. Possible metformin-induced hepatotoxicity. Am J Geriatr Pharmacother. 2005;3(4):270-273.
19. Cone C, Bachyrycz A, Murata G. Hepatotoxicity associated with metformin therapy in treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease. Ann Pharmacother. 2010;44(10): 1655-1659.