Macrophage-derived, macrophage migration inhibitory factor (MIF) is necessary to induce disease in the K/BxN serum-induced model of arthritis

Rheumatology International

Volumn 33, Issue 9, 2013, Pages 2301-2308

  Singh, Anjana ^a   Leng, Lin ^b   Fan, Juan ^b   Gajda, Mieczyslaw ^c   Bräuer, Rolf ^c   Fingerle Rowson, Günter ^d   Bucala, Richard ^b   Illges, Harald ^a  

^a UNIVERSITY OF APPLIED SCIENCES   (Germany)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JENA UNIVERSITY HOSPITAL   (Germany)

^d UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Cytokine; Fibroblast like synoviocytes (FLS); Macrophage; Macrophage migration inhibitory factor; Rheumatoid arthritis

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE MIGRATION INHIBITION FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; DISEASE SEVERITY; ENDOTOXEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; JOINT DESTRUCTION; JOINT SWELLING; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PATHOGENESIS; PERIPHERAL LYMPHOCYTE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROGENY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIUM; WILD TYPE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CYTOKINES; DISEASE MODELS, ANIMAL; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MACROPHAGES; MICE; MICE, INBRED C57BL;

EID: 84883192308     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-013-2713-4     Document Type: Article

References (30)

1. Feldmann M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397-440
2. Calandra T et al (1994) The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J Exp Med 179(6):1895-1902
3. Bacher M et al (1996) An essential regulatory role for macrophage migration inhibitory factor in T-cell activation. Proc Natl Acad Sci USA 93(15):7849-7854
4. David JR (1966) Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci USA 56(1):72-77
5. Leech M et al (1999) Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids. Arthritis Rheum 42(8):1601-1608
6. Sampey AV et al (2001) Regulation of synoviocyte phospholipase A2 and cyclooxygenase 2 by macrophage migration inhibitory factor. Arthritis Rheum 44(6):1273-1280
7. Foote A et al (2004) Macrophage migration inhibitory factor in systemic lupus erythematosus. J Rheumatol 31(2):268-273
8. Onodera S et al (2004) Macrophage migration inhibitory factor up-regulates the expression of interleukin-8 messenger RNA in synovial fibroblasts of rheumatoid arthritis patients: common transcriptional regulatory mechanism between interleukin-8 and interleukin-1β. Arthritis Rheum 50(5):1437-1447
9. Onodera S et al (2000) Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis. J Biol Chem 275(1):444-450
10. Gregory JL et al (2004) Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice. Arthritis Rheum 50(9):3023-3034
11. Kim HR et al (2011) Macrophage migration inhibitory factor enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis. Arthritis Res Ther 13(2):R43
12. Mikulowska A et al (1997) Macrophage migration inhibitory factor is involved in the pathogenesis of collagen type II-induced arthritis in mice. J Immunol 158(11):5514-5517
13. Leech M et al (1998) Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis. Arthritis Rheum 41(5):910-917
14. Santos L et al (2001) Role of macrophage migration inhibitory factor (MIF) in murine antigen-induced arthritis: interaction with glucocorticoids. Clin Exp Immunol 123(2):309-314
15. Radstake TR et al (2005) Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor. Arthritis Rheum 52(10):3020-3029
16. Santos LL et al (2011) Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice. Arthritis Rheum 63(4):960-970
17. Santos LL et al (2008) Reduced arthritis in MIF deficient mice is associated with reduced T cell activation: down-regulation of ERK MAP kinase phosphorylation. Clin Exp Immunol 152(2):372-380
18. Herrero LJ et al (2011) Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis. Proc Natl Acad Sci USA 108(29):12048-12053
19. Kouskoff V et al (1996) Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-822
20. Solomon S et al (2005) A crucial role for macrophages in the pathology of K/BxN serum-induced arthritis. Eur J Immunol 35(10):3064-3073
21. Bernhagen J et al (1994) Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF). Biochemistry 33(47):14144-14155
22. Fingerle-Rowson G et al (2003) The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci USA 100(16):9354-9359
23. Maini RN et al (1993) TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy. Clin Exp Rheumatol 11(Suppl 8):S173-S175
24. Leech M et al (2003) Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis. Arthritis Rheum 48(7):1881-1889
25. Leech M et al (2000) Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant-induced arthritis. Arthritis Rheum 43(4):827-833
26. Lacey D et al (2003) Control of fibroblast-like synoviocyte proliferation by macrophage migration inhibitory factor. Arthritis Rheum 48(1):103-109
27. Llamas-Covarrubias MA et al (2012) Serum levels of macrophage migration inhibitory factor are associated with rheumatoid arthritis course. Rheumatol Int 32(8):2307-2311
28. Paiva CN et al (2009) Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction. J Leukoc Biol 85(5):855-861
29. Ji H et al (2002) Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 196(1):77-85
30. Choe JY et al (2003) Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling. J Exp Med 197(4):537-542