Assessment of reactivity of three treponemal tests in non-treponemal non-reactive cases from sexually transmitted diseases clinic, antenatal clinic, integrated counselling and testing centre, other different outdoor patient departments/indoor patients of a tertiary care centre and peripheral health clinic attendees

Indian Journal of Medical Microbiology

Volumn 31, Issue 3, 2013, Pages 275-279

  Bala, M ^a   Singh, V ^a   Muralidhar, S ^a   Ramesh, V ^a  

^a SAFDARJUNG HOSPITAL   (India)

Author keywords

Fluorescent treponemal antibody absorption; non treponemal tests; syphilis; Treponema pallidum haemagglutination; treponemal tests

Indexed keywords

ABSORPTION; ARTICLE; CONTROLLED STUDY; COUNSELING; ENZYME IMMUNOASSAY; FEMALE; FLUORESCENT TREPONEMA ANTIBODY TEST; HUMAN; MAJOR CLINICAL STUDY; MALE; QUALITY CONTROL; SEROPREVALENCE; SEXUALLY TRANSMITTED DISEASE; SYPHILIS; TERTIARY HEALTH CARE; TREPONEMA PALLIDUM HEMAGGLUTINATION TEST;

EID: 84883184852     PISSN: 02550857     EISSN: 19983646     Source Type: Journal    
DOI: 10.4103/0255-0857.115638     Document Type: Article

References (15)

1. Ray K, Bala M, Gupta SM, Khunger N, Puri P, Muralidhar S, et al. Changing trends in sexually transmitted infections at a Regional STD Centre in north India. Indian J Med Res 2006;124:559-68.
2. Müller I, Brade V, Hagedorn HJ, Straube E, Schörner C, Frosch M, et al. Is serological testing a reliable tool in laboratory diagnosis of syphilis- Meta-analysis of eight external quality control surveys performed by the German infection serology proficiency testing program. J Clin Microbiol 2006;44:1335-41.
3. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines, 2010. MMWR Morb Mortal Wkly Rep 2010;59:27-8. Available from: http://www.cdc.gov/std/treatment/2010. [Last accessed on 2012 Nov 16].
4. Centers for Disease Control and Prevention (CDC). Discordant results from reverse sequence syphilis screening - Five laboratories, United States, 2006-2010. MMWR Morb Mortal Wkly Rep 2011;60:133-7.
5. Karaca Y, Cöplü N, Gözalan A, Oncül O, Akin L, Esen B. Establishment of an algorithm for serological testing of syphilis identification. Mikrobiyol Bul 2010;44:35-45.
6. Gupta SM, Bala M, Muralidhar S, Ray K. Evaluation of test results of microbiology laboratories of North India for standard tests for syphilis under an external quality assurance scheme. Eur J Clin Microbiol Infect Dis 2009;28:461-8.
7. Cole MJ, Perry KR, Parry JV. Comparative evaluation of 15 serological assays for the detection of syphilis infection. Eur J Clin Microbiol Infect Dis 2007;26:705-13.
8. Maple PA, Ratcliffe D, Smit E. Characterization of Treponema pallidum particle agglutination assay-negative sera following screening by treponemal total antibody enzyme immunoassays. Clin Vaccine Immunol 2010;17:1718-22.
9. Health Protection Agency. Serological Diagnosis of Syphilis. National Standard Method, London, United Kingdom. 2007;V44. Available from: http://www.hpa-standardmethods. org.uk. [Last accessed on 2012 Aug 20].
10. Larson SA, Pope V, Johnson RE, Kennedy EJ. A Manual of Tests for Syphilis. 9th ed. Washington DC: American Public Health Association; 1998.
11. Aktas G, Young H, Moyes A, Badur S. Evaluation of the fluorescent treponemal antibody absorption test for detection of antibodies (immunoglobulins G and M) to Treponema pallidum in serologic diagnosis of syphilis. Int J STD AIDS 2007;18:255-60.
12. Chronas G, Moyes A, Young H. Syphilis diagnosis: Screening by enzyme immunoassay and variation in fluorescent treponemal antibody absorbed (FTA-ABS) confirmatory test performance. Med Lab Sci 1992;49:50-5.
13. Young H, Henrichsen C, Robertson DH. Treponema pallidum haemagglutination test as a screening procedure for the diagnosis of syphilis. Br J Vener Dis 1974;50:341-6.
14. Bala M, Toor A, Malhotra M, Kakran M, Muralidhar S, Ramesh V. Evaluation of the usefulness of Treponema pallidum hemagglutination test in the diagnosis of syphilis in weak reactive venereal disease research laboratory sera. Indian J Sex Transm Dis 2012;33:102-6.
15. Geusau A, Kittler H, Hein U, Dangl-Erlach E, Stingl G, Tschachler E. Biological false-positive tests comprise a high proportion of venereal disease research laboratory reactions in an analysis of 300,000 sera. Int J STD AIDS 2005;16:722-6