Systemic and local human cytomegalovirus-specific T-cell response in lung transplant recipients

New Microbiologica

Volumn 36, Issue 3, 2013, Pages 267-277

  Lilleri, Daniele ^a   Gerna, Giuseppe ^a   Bruno, Francesca ^a   Draghi, Paola ^a   Gabanti, Elisa ^a   Fornara, Chiara ^a   Meloni, Federica ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Enzyme linked immunospot (ELISpot) assay; Intracellular cytoplasmic staining; Local (lung) HCMV immunity; Lung transplant recipients; Systemic HCMV T cell immunity

Indexed keywords

VIRUS DNA;

ADOLESCENT; ADULT; ARTICLE; BLOOD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; ENZYME LINKED IMMUNOSPOT ASSAY; EPIDEMIOLOGY; FEMALE; HUMAN; IMMUNOLOGY; LUNG; LUNG TRANSPLANTATION; MALE; MONONUCLEAR CELL; PROSPECTIVE STUDY; VIROLOGY; VIRUS LOAD; YOUNG ADULT;

ADOLESCENT; ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; ENZYME-LINKED IMMUNOSPOT ASSAY; FEMALE; HUMANS; IMMUNITY, CELLULAR; LEUKOCYTES, MONONUCLEAR; LUNG; LUNG TRANSPLANTATION; MALE; PROSPECTIVE STUDIES; SEROEPIDEMIOLOGIC STUDIES; VIRAL LOAD; YOUNG ADULT;

EID: 84883162770     PISSN: 11217138     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. BAUER C.C., JAKSCH P., ABERLE S.W., HABER H., LANG G., KLEPETKO W., ET AL. (2007). Relationship between cytomegalovirus DNA load in epithelial lining fluid and plasma in lung transplant recipients and analysis of coinfection with Epstein-Barr virus and human herpesvirus 6 in the lung compartment. J. Clin. Microbiol. 45, 324-328.
2. BENMARZOUK-HIDALGO O.J., CISNEROS J.M., CORDERO E., MARTÍN- PEÑA A., SANCHEZ B., MARTIN-GANDUL C., ET AL. (2011). Therapeutic effect of the acquisition of cytomegalovirus-specific immune response during preemptive treatment. Transplantation. 91, 927-933.
3. CHEMALY R.F., YEN-LIEBERMAN B., CHAPMAN J., REILLY A., BEKELE B.N., GORDON S.M., ET AL. (2005). Clinical utility of cytomegalovirus viral load in bronchoalveolar lavage in lung transplant recipients. Am. J. Transplant. 5, 544-548.
4. D'AMBROSIO D., MARIANI M., PANINA-BORDIGNON P., SINIGAGLIA F. (2001). Chemokines and their receptors guiding T lymphocyte recruitment in lung inflammation. Am. J. Respir. Crit. Care Med. 164, 1266-1275.
5. DE BREE G.J., VAN LEEUWEN E.M., OUT T.A., JANSEN H.M., JONKERS R.E., VAN LIER R.A. (2005). Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung. J. Exp. Med. 202, 1433-1442.
6. FURIONE M., ROGNONI V., CABANO E., BALDANTI F. (2012). kinetics of human citomegalovirus (HCMV) DNAemia in transplanted patients expressed in international units as determined with the Abbot realtime CMV assay and an in-house assay. J. Clin. Virol. 55, 317-322.
7. GAMADIA L.E., REMMERSWAAL E.B., WEEL J.F., BEMELMAN F., VAN LIER R.A., TEN BERGE I.J. (2003). Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease. Blood. 101, 2686-2692.
8. GERNA G., BALDANTI F., TORSELLINI M., MINOLI L., VIGANÒ M., OGGIONNI T., ET AL. (2007). Evaluation of cytomegalovirus DNAemia versus pp65-antigenemia cut-off for guiding preemptive therapy in transplant recipients: a randomized study. Antiviral. Ther. 12, 63-72.
9. GERNA G., LILLERI D., CHIESA A., ZELINI P., FURIONE M., COMOLLI G., ET AL. (2011). Virologic and immunologic monitoring of cytomegalovirus to guide preemptive therapy in solid-organ transplantation. Am. J. Transplant. 11, 2463-2471.
10. GERNA G., LILLERI D., FORNARA C., COMOLLI G., LOZZA L., CAMPANA C., ET AL. (2006). Monitoring of human cytomegalovirus- specific CD4+ and CD8+ T-cell immunity in patients receiving solid organ transplantation. Am. J. Transplant. 6, 2356-2364.
11. GERNA G., LILLERI D., FURIONE M., CASTIGLIONI B., MELONI F., RAMPINO T., ET AL. (2012). Human cytomegalovirus end-organ disease is associated with high or low systemic viral load in pre-emptively treated solid-organ transplant recipients. New Microbiol. 35, 279-287.
12. GERNA G., LILLERI D., ROGNONI V., AGOZZINO M., MELONI F., OGGIONNI T., ET AL. (2009). Preemptive therapy for systemic and pulmonary human cytomegalovirus infection in lung transplant recipients. Am. J. Transplant. 9, 1142-1150.
13. GERNA G., VITULO P., ROVIDA F., LILLERI D., PELLEGRINI C., OGGIONNI T., ET AL. (2006). Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients. J. Med. Virol. 78, 408-416. Erratum in:J. Med. Virol. (2008) 80, 1869.
14. LOZZA L., LILLERI D., PERCIVALLE E., FORNARA C., COMOLLI G., REVELLO M.G., ET AL. (2005). Simultaneous quantification of human cytomegalovirus (HCMV)-specific CD4+ and CD8+ T cells by a novel method using monocyte-derived HCMV-infected immature dendritic cells. Eur. J. Immunol. 35, 1795-1804.
15. PIPELING M.R., WEST E.E., OSBORNE C.M., WHITLOCK A.B., DROPULIC L.K., WILLETT M.H., ET AL. (2008). Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection. J. Immunol. 181, 546-556.
16. ROWSHANI A.T., BEMELMAN F.J., VAN LEEUWEN E.M.M., VAN LIER R.A.W., TEN BERGE J.M. (2005). Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients. Transplantation. 79, 381-386.
17. SCHAERLI P., MOSER B. (2005). Chemokines: control of primary and memory T-cell traffic. Immunol. Res. 31: 57-74.
18. SESTER U., GARTNER B.C., WILKENS H., SCHWAAB B., WÖSSNER R., KINDERMANN I., ET AL. (2005). Differences in CMV-specific T-cell levels and longterm susceptibility to CMV infection after kidney, heart and lung transplantation. Am. J. Transplant. 5, 1483-1489.
19. SHLOBIN O.A., WEST E.E., LECHTZIN N., MILLER S.M., BORJA M., ORENS J.B., ET AL. (2006). Persistent cytomegalovirus- specific memory responses in the lung allograft and blood following primary infection in lung transplant recipients. J. Immunol. 176, 2625-2634.
20. WALDROP S.L., PITCHER C.J., PETERSON D.M., MAINO V.C., PICKER L.J. (1997). Determination of antigenspecific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigenspecific homeostatic mechanism in HIV-associated immunodeficiency. J. Clin. Invest. 99, 1739-1750.
21. WESESLINDTNER L., KERSCHNER H., STEINACHER D., NACHBAGAUER R., KUNDIM., JAKSCH P., ET AL. (2012). Prospective analysis of human cytomegalovirus DNAemia and specific CD8+ T cell responses in lung transplant recipients. Am. J. Transplant. 12, 2172-2180.
22. WESTALL G., KOTSIMBOS T., BROOKS A. (2006). CMVspecific CD8 T-cell dynamics in the blood and the lung allograft reflect viral reactivation following lung transplantation. Am. J. Transplant. 6, 577-584.
23. WESTALL G.P., MICHAELIDIS A., WILLIAMS T.J., SNELL J.I., KOTSIMBOS T.C. (2004). Human cytomegalovirus load in plasma and bronchoalveolar lavage fluid: a longitudinal study of lung quantitative real-time PCR for monitoring clinical intervention in transplant recipients. J. Infect. Dis. 190, 1076-1083.
24. ZEEVI A., MOREL P., SPICHTY K., DAUBER J., YOUSEM S., WILLIAMS P., ET AL. (1998). Clinical significance of CMV-specific T helper responses in lung transplant recipients. Hum. Immunol. 59, 768-775.
25. ZEEVI A., UKNIS M.E., SPICHTY K.J., TECTOR M., KEENAN R.J., RINALDO C., ET AL. (1992). Proliferation of cytomegalovirus- primed lymphocytes in bronchoalveolar lavages from lung transplant patients. Transplantation. 54, 635-639.