Yeast as a platform to explore polyglutamine toxicity and aggregation

Methods in Molecular Biology

Volumn 1017, Issue , 2013, Pages 153-161

  Duennwald, Martin L ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

Neurodegeneration; Polyglutamine aggregation; Polyglutamine toxicity; Protein misfolding; Yeast model

Indexed keywords

POLYGLUTAMINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; FUNGAL STRAIN; HUNTINGTON CHOREA; LIQUID CULTURE; MICROBIOLOGY; MOUSE; NERVE DEGENERATION; NONHUMAN; PATHOLOGY; POLYGLUTAMINE TOXICITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN UNFOLDING; SACCHAROMYCES CEREVISIAE; TOXICITY; YEAST;

SACCHAROMYCES CEREVISIAE;

EID: 84883150147     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-438-8_11     Document Type: Article

References (13)

1. Soto C (2003) Unfolding the role of protein misfolding in neurodegenerative diseases. Nat Rev Neurosci 4(1):49-60. doi: 10.1038/nrn1007 nrn1007 [pii]
2. Soto C, Estrada LD (2008) Protein misfolding and neurodegeneration. Arch Neurol 65(2):184-189. doi: 65/2/184 [pii] 10.1001/archneurol.2007.56
3. Duennwald ML, Jagadish S, Giorgini F, Muchowski PJ, Lindquist S (2006) A network of protein interactions determines polyglutamine toxicity. Proc Natl Acad Sci USA 103(29):11051-11056. doi: 0604548103 [pii] 10.1073/pnas.0604548103
4. Duennwald ML, Jagadish S, Muchowski PJ, Lindquist S (2006) Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proc Natl Acad Sci USA 103(29):11045-11050. doi: 0604547103 [pii] 10.1073/pnas.0604547103
5. Krobitsch S, Lindquist S (2000) Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc Natl Acad Sci USA 97(4):1589-1594. doi: 97/4/1589 [pii]
6. Meriin AB, Zhang X, He X, Newnam GP, Chernoff YO, Sherman MY (2002) Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. J Cell Biol 157(6):997-1004. doi: 10.1083/jcb.200112104 jcb.200112104 [pii]
7. Muchowski PJ, Schaffar G, Sittler A, Wanker EE, Hayer-Hartl MK, Hartl FU (2000) Hsp70 and hsp40 chaperones can inhibit selfassembly of polyglutamine proteins into amyloid-likefibrils. Proc Natl Acad Sci USA 97(14):7841-7846. doi: 10.1073/pnas.140202897 140202897 [pii]
8. Giorgini F, Muchowski PJ (2009) Exploiting yeast genetics to inform therapeutic strategies for Huntington's disease. Methods Mol Biol 548:161-174. doi: 10.1007/978-1-59745-540-4-9
9. Sherman MY, Muchowski PJ (2003) Making yeast tremble: Yeast models as tools to study neurodegenerative disorders. Neuromolecular Med 4(1-2):133-146. doi: NMM:4:1-2:133 [pii] 10.1385/NMM:4:1-2:133
10. Winderickx J, Delay C, De Vos A, Klinger H, Pellens K, Vanhelmont T, Van Leuven F, Zabrocki P (2008) Protein folding diseases and neurodegeneration: Lessons learned from yeast. Biochim Biophys Acta 1783(7):1381-1395. doi: S0167-4889(08)00046-3 [pii] 10.1016/j. bbamcr.2008.01.020
11. Shorter J, Lindquist S (2005) Prions as adaptive conduits of memory and inheritance. Nat Rev Genet 6(6):435-450. doi: Nrg1616 [pii] 10.1038/nrg1616
12. Sondheimer N, Lindquist S (2000) Rnq1: An epigenetic modifier of protein function in yeast. Mol Cell 5(1):163-172. doi: S1097-2765 (00)80412-8 [pii]
13. Duennwald ML (2011) Monitoring polyglutamine toxicity in yeast. Methods 53(3): 232-237. doi: S1046-2023(10)00284-7 [pii] 10.1016/j.ymeth.2010.12.001