Liver enzymes and vitamin D levels in metabolically healthy but obese individuals: Korean National Health and Nutrition Examination Survey

Metabolism: Clinical and Experimental

Volumn 62, Issue 9, 2013, Pages 1305-1312

  Hong, Ho Cheol ^a   Lee, Ji Sung ^b   Choi, Hae Yoon ^a   Yang, Sae Jeong ^a   Yoo, Hye Jin ^a   Seo, Ji A ^a   Kim, Sin Gon ^a   Kim, Nan Hee ^a   Baik, Sei Hyun ^a   Choi, Dong Seop ^a   Choi, Kyung Mook ^a  

^a Korea University College of Medicine   (South Korea)

^b Korea University College of Medicine   (South Korea)

Author keywords

Body size phenotype; MHO; NAFLD; Obesity metabolism; Vitamin D

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VITAMIN D;

ADULT; AGE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; BODY SIZE; CARDIOMETABOLIC RISK; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; HEALTH SURVEY; HUMAN; INSULIN RESISTANCE; KOREA; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; OBESITY; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SEX; SYSTOLIC BLOOD PRESSURE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; WAIST CIRCUMFERENCE;

25(OH)D; 25-HYDROXYVITAMIN D; BMI; BODY MASS INDEX; BODY SIZE PHENOTYPE; CARDIOVASCULAR DISEASE; CI; CONFIDENCE INTERVAL; CVD; FOURTH KOREAN NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY; KNHANES IV; MAO; METABOLICALLY ABNORMAL OBESE; METABOLICALLY HEALTHY BUT OBESE; MHO; NAFLD; NHANES III; NONALCOHOLIC FATTY LIVER DISEASE; OBESITY METABOLISM; ODDS RATIO; OR; THIRD NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY IN THE UNITED STATES; VITAMIN D;

ADULT; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BODY MASS INDEX; FEMALE; HUMANS; KOREA; LIVER; LOGISTIC MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NUTRITION SURVEYS; OBESITY; VITAMIN D;

EID: 84883146701     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.04.002     Document Type: Article

References (38)

1. V. Primeau, L. Coderre, and A.D. Karelis Characterizing the profile of obese patients who are metabolically healthy Int J Obes (Lond) 35 2011 971 981
2. R.P. Wildman, R. Kaplan, and J.E. Manson Body size phenotypes and inflammation in the Women's Health Initiative observational study Obesity 19 2011 1482 1491
3. A.D. Karelis, D.H. St-Pierre, and F. Conus Metabolic and body composition factors in subgroups of obesity: what do we know? J Clin Endocrinol Metab 89 2004 2569 2575
4. G. Calori, G. Lattuada, and L. Piemonti Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona Study Diabetes Care 34 2011 210 215
5. S.W. Oh Obesity and metabolic syndrome in Korea Diabetes Metab J 35 2011 561 566
6. N. Stefan, K. Kantartzis, and J. Machann Identification and characterization of metabolically benign obesity in humans Arch Intern Med 168 2008 1609 1616
7. V. Messier, A.D. Karelis, and M.E. Robillard Metabolically healthy but obese individuals: relationship with hepatic enzymes Metabolism 59 2010 20 24
8. R. Scragg, M. Sowers, and C. Bell Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey Diabetes Care 27 2004 2813 2818
9. E.S. Ford, U.A. Ajani, and L.C. McGuire Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults Diabetes Care 28 2005 1228 1230
10. I. Barchetta, F. Angelico, and M. Del Ben Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes BMC Med 9 2011 85
11. H.S. Choi, H.J. Oh, and H. Choi Vitamin D insufficiency in Korea - a greater threat to younger generation: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008 J Clin Endocrinol Metab 96 2010 643 651
12. S.M. Kim, J.S. Lee, and J. Lee Prevalence of diabetes and impaired fasting glucose in Korea: Korean National Health and Nutrition Survey 2001 Diabetes Care 29 2006 226 231
13. World Health Organization Western PacificRegion, International Association for the Study of Obesity, International Obesity Task Force The Asia-Pacific perspective: redefining obesity and its treatment 2000 Sydney Health Communications Australia
14. J.K. Lee, J.H. Shim, and H.C. Lee Estimation of the healthy upper limits for serum alanine aminotransferase in Asian populations with normal liver histology Hepatology 51 2010 1577 1583
15. M.F. Holick, N.C. Binkley, and H.A. Bischoff-Ferrari Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline J Clin Endocrinol Metab 96 2011 1911 1930
16. M. Kim, J.K. Paik, and R. Kang Increased oxidative stress in normal-weight postmenopausal women with metabolic syndrome compared with metabolically healthy overweight/obese individuals Metabolism 2012
17. J.B. Meigs, P.W. Wilson, and C.S. Fox Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease J Clin Endocrinol Metab 91 2006 2906 2912
18. S. Velho, F. Paccaud, and G. Waeber Metabolically healthy obesity: different prevalences using different criteria Eur J Clin Nutr 64 2010 1043 1051
19. R.P. Wildman, P. Muntner, and K. Reynolds The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004) Arch Intern Med 168 2008 1617 1624
20. J. Szendroedi, and M. Roden Ectopic lipids and organ function Curr Opin Lipidol 20 2009 50 56
21. E. D'Adamo, A.M. Cali, and R. Weiss Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents Diabetes Care 33 2010 1817 1822
22. B.P. Mulhall, J.P. Ong, and Z.M. Younossi Non-alcoholic fatty liver disease: an overview J Gastroenterol Hepatol 17 2002 1136 1143
23. P. Angulo Nonalcoholic fatty liver disease N Engl J Med 346 2002 1221 1231
24. E. Vanni, E. Bugianesi, and A. Kotronen From the metabolic syndrome to NAFLD or vice versa? Dig Liver Dis 42 2010 320 330
25. S. Liangpunsakul, and N. Chalasani Serum vitamin D concentrations and unexplained elevation in ALT among US adults Dig Dis Sci 56 2011 2124 2129
26. G. Targher, L. Bertolini, and L. Scala Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease Nutr Metab Cardiovasc Dis 17 2007 517 524
27. A.M. Renzaho, J.A. Halliday, and C. Nowson Vitamin D, obesity, and obesity-related chronic disease among ethnic minorities: a systematic review Nutrition 27 2011 868 879
28. M.K. Kim, M. Il Kang, and K. Won Oh The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle-aged Korean subjects Clin Endocrinol (Oxf) 73 2010 330 338
29. S. Kim, J. Lim, and S. Kye Association between vitamin D status and metabolic syndrome risk among Korean population: based on the Korean National Health and Nutrition Examination Survey IV-2, 2008 Diabetes Res Clin Pract 96 2012 230 236
30. M. Brochu, A. Tchernof, and I.J. Dionne What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J Clin Endocrinol Metab 86 2001 1020 1025
31. A.D. Karelis, M. Brochu, and R. Rabasa-Lhoret Can we identify metabolically healthy but obese individuals (MHO)? Diabetes Metab 30 2004 569 572
32. C.A. Aguilar-Salinas, E.G. Garcia, and L. Robles High adiponectin concentrations are associated with the metabolically healthy obese phenotype J Clin Endocrinol Metab 93 2008 4075 4079
33. L.A. Lynch, J.M. O'Connell, and A.K. Kwasnik Are natural killer cells protecting the metabolically healthy obese patient? Obesity (Silver Spring) 17 2009 601 605
34. G. Iacobellis, M.C. Ribaudo, and A. Zappaterreno Prevalence of uncomplicated obesity in an Italian obese population Obes Res 13 2005 1116 1122
35. J.L. Shea, E.W. Randell, and G. Sun The prevalence of metabolically healthy obese subjects defined by BMI and dual-energy x-ray absorptiometry Obesity (Silver Spring) 19 2011 624 630
36. M.A. Marini, E. Succurro, and S. Frontoni Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women Diabetes Care 30 2007 2145 2147
37. M.M. Ibrahim Subcutaneous and visceral adipose tissue: structural and functional differences Obes Rev 11 2010 11 18
38. H.J. Yoo, M.S. Park, and C.H. Lee Cutoff points of abdominal obesity indices in screening for non-alcoholic fatty liver disease in Asians Liver Int 30 2010 1189 1196