Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: A double-blind, randomised, controlled trial

Archives of Disease in Childhood

Volumn 98, Issue 9, 2013, Pages 721-724

  Neri, Elena ^a   Maestro, Alessandra ^a   Minen, Federico ^b   Montico, Marcella ^a   Ronfani, Luca ^a   Zanon, Davide ^a   Favret, Anna ^b   Messi, Gianni ^a   Barbi, Egidio ^a  

^a INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; KETOROLAC; PARACETAMOL; TRAMADOL;

ADOLESCENT; ANALGESIA; ARTICLE; BONE PAIN; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; DISLOCATION; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; LIMB FRACTURE; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; VISUAL ANALOG SCALE; VOMITING; XEROSTOMIA;

ANALGESIA; GENERAL PAEDIATRICS; PAIN;

ADMINISTRATION, SUBLINGUAL; ADOLESCENT; ANALGESICS, OPIOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHILD; CHILD, PRESCHOOL; DISLOCATIONS; DOUBLE-BLIND METHOD; EMERGENCY SERVICE, HOSPITAL; FEMALE; FRACTURES, BONE; HUMANS; KETOROLAC; MALE; PAIN MANAGEMENT; PAIN MEASUREMENT; TRAMADOL; TREATMENT OUTCOME;

EID: 84883133061     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/archdischild-2012-303527     Document Type: Article

References (31)

1. Cooper C, Dennison EM, Leufkens HGM, et al. Epidemiology of childhood fractures in Britain: a study using the general practice research database. J Bone Miner Res 2004;19:1976-81.
2. Alexander J, Manno M. Underuse of analgesia in very young pediatric patients with isolated painful injuries. Ann Emerg Med 2003;41:617-22.
3. Clark E, Plint AC, Correll R, et al. A randomized, controlled trial of acetaminophen, ibuprofen and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics 2007;119:460-7.
4. Ali S, Drenedel AL, Kircher J, et al. Pain management of musculoskeletal injuries in children: current state and futire directions. Pediatr Emerg Care 2010;26:518-24.
5. Drendel AL, Gorelick MH, Weisman SJ, et al. A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. Ann Emerg Med 2009;54:553-60.
6. Pierce MC, Fuchs S. Evaluation of Ketorolac in Children with Forearm Fractures. Acad Emerg Med 1997;4:22-6.
7. Raffa RB, Friderichs E, Reimann W, et al. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. Journal of Pharmacology and Experimental Therapeutics 1992;260:275-85.
8. Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet 2004;43:879-923.
9. Lewis KS, Han NH. Tramadol: a new centrally acting analgesic. Am J Health Sys Pharmacy 1997;54:643-52.
10. Ortiz MI, Monroy-Maya R, Soto-Rìos M, et al. Effectiveness of diclofenac, ketorolac and eterocoxib in the treatment of acute pain from ankle fracture. Proc West Pharmacol Soc 2010;53;46-8.
11. Cander B, Girisgin S, Koylu R, et al. The effectiveness of analgesics in traumatic injuries of the extremities. Adv Ther 2005;22:462-6.
12. Hoogewijs J, Diltoer MW, Hubloue I, et al. A prospective, open, single blind, randomized study comparing four analgesics in the treatment of peripheral injury in the emergency department. Eur J Emerg Med 2000;7:119-23.
13. Bourne MH. Analgesics for orthopaedic postoperative pain. Am J Orthop (Belle Mead NJ) 2004;33:128-35.
14. Zackova M, Taddei S, Calò P, et al. Ketorolac vs tramadol in the treatment of postoperative pain during maxillofacial surgery. Minerva Anestesiol 2001;67:41-6.
15. Putland AJ, McCliskey A. The analgesic efficacy of tramadol versus ketorolac in day-case laparoscopic sterilisation. Anesthesia 1999;54:372-92.
16. Ong KS, Tan JML. Preoperative intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery. Int J Oral Maxillofac Surg 2004;33:274-8.
17. Pieri M, Meacci L, Santini L, et al. Control of acute pain after major abdominal surgery in 585 patients given tramadol and ketorolac by intravenpous infusion. Drugs Exptl Clin Res 2002;28:113-18.
18. Brown CR, Mazzulla JP, Mok MS, et al. Comparison of repeat doses of intramuscular ketorolac tromethamine and morphine sulfate for analgesia after major surgery. Pharmacotherapy 1990;10:45S-50S.
19. Yee JP, Koshiver JE, Allbon C, et al. Comparison of intramuscular ketorolac tromethamine and morphine sulfate for analgesia of pain after major surgery. Pharmacotherapy 1986;6:253-61.
20. Lepri A, Sia S, Catinelli S, et al. Patient-controlled analgesia with tramadol versus tramdaol plus ketorolac. Minerva anestesiol 2006;72:59-67.
21. Alexander R, El-Moalem HE, Gan TJ. Comparison of the morphine- sèaring effects of diclofenac sodium and ketorolac tromethamine after major orthopaedic surgery. J Clin Anesth 2002;14:187-92.
22. Kay RM, Directo MP, Leathers M, et al. Complications of ketorolac use in children undergoing operative fracture care. J Pediatr Orthop 2010;30:655-8.
23. Watcha MF, Jones MB, Languerela LG, et al. Comparison of ketorolac and morphine as adjuvants during pediatric surgery. Anesthesiology 1992;76:368-72.
24. Diaz-Chavez EP, Medina-Chavez JL, Avalos-Gonzalez J, et al. Comparison of sublingual ketorolac vs. IV metamizol in the management of pain after same-day surgery. Cir cir 2009;77:45-9.
25. Minkowitz HS, Singla NK, Evashenk MA, et al. Pharmacokinetics of sublingual sufentanil tablets and efficacy and safety in the management of postoperative apin. Reg Anesth Pain Med 2013;38:131-9.
26. Lottmann H. Comparison of two sublingual types of desmopressin in 6-year-old and more children with primary nocturnal enuresis. About an international randomized cross-over study. Prog Urol 2009;19:132-8.
27. Garcia-Marcos L, Lucas Moreno JM, Garde JG. Sublingual specific immunotherapy: state of the art. Inflamm Allergy Drug Targets 2007;6:117-26.
28. Borland M, Jacobs I, King B, et al. A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department. Ann Emerg Med 2007;49:335-40.
29. Davies M, Crawford I. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Nasal diamorphine for acute pain relief in children. Emerg Med J 2001;18:271.
30. Kendall JM, Reeves BC, Latter VS; Nasal Diamorphine Trial Group. Multicentre randomised controlled trial of nasal diamorphine for analgesia in children and teenagers with clinical fractures. BMJ 2001;322:261-5.
31. Kirchheiner J, Keulen JT, Bauer S, et al. Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol. J Clin Psychopharmacol 2008;28:78-83.