Analysis of 3 common polymorphisms in the KCNK18 gene in an Australian Migraine Case-control cohort

Gene

Volumn 528, Issue 2, 2013, Pages 343-346

  Maher, B H ^a   Taylor, M ^a   Stuart, S ^a   Okolicsanyi, R K ^a   Roy, B ^a   Sutherland, H G ^a   Haupt, L M ^a   Griffiths, L R ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

KCNK18; Migraine; Migraine with Aura; TRESK

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNK18; POTASSIUM CHANNEL TRESK; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUSTRALIA; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MIGRAINE; MIGRAINE WITH AURA; NUCLEOTIDE SEQUENCE; PHENOTYPE; POPULATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

FAMILIAL HEMIPLEGIC MIGRAINE; FHM; KCNK18; MA; MIGRAINE; MIGRAINE WITH AURA; MIGRAINE WITHOUT AURA; MO; POTASSIUM CHANNEL, SUBFAMILY K, MEMBER 18 GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RFLP; SINGLE NUCLEOTIDE POLYMORPHISM; SNP; TRESK; TWIK-RELATED SPINAL CORD POTASSIUM CHANNEL;

AUSTRALIA; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; MIGRAINE DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM CHANNELS; SEQUENCE ANALYSIS, DNA;

EID: 84883054428     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.07.030     Document Type: Article

References (24)

1. Andres-Enguix I., et al. Functional analysis of missense variants in the TRESK (KCNK18) K channel. Sci. Rep. 2012, 2:237.
2. Anttila V., et al. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat. Genet. 2010, 42:869-873.
3. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
4. Chasman D.I., et al. Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat. Genet. 2011, 43:695-698.
5. Cox H.C., et al. Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk Island. Gene 2012, 494:119-123.
6. De Fusco M., et al. Haploinsufficiency of ATP1A2 encoding the Na+/K+pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat. Genet. 2003, 33:192-196.
7. Dichgans M., et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 2005, 366:371-377.
8. Dobler T., et al. TRESK two-pore-domain K+channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones. J. Physiol. 2007, 585:867-879.
9. Enyedi P., Braun G., Czirjak G. TRESK: the lone ranger of two-pore domain potassium channels. Mol. Cell. Endocrinol. 2012, 353:75-81.
10. Gervil M., Ulrich V., Kyvik K.O., Olesen J., Russell M.B. Migraine without aura: a population-based twin study. Ann. Neurol. 1999, 46:606-611.
11. Huang D.Y., Yu B.W., Fan Q.W. Roles of TRESK, a novel two-pore domain K+channel, in pain pathway and general anesthesia. Neurosci. Bull. 2008, 24:166-172.
12. IHS The International Classification of the Headache Disorders 2nd ed. Cephalalgia 2004, 24(Suppl. 1):1-150.
13. Lafreniere R.G., Rouleau G.A. Migraine: role of the TRESK two-pore potassium channel. Int. J. Biochem. Cell Biol. 2011, 43:1533-1536.
14. Lafreniere R.G., et al. A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. Nat. Med. 2010, 16(10):1157-1160.
15. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res. 1988, 16:1215.
16. Mulder E.J., et al. Genetic and environmental influences on migraine: a twin study across six countries. Twin Res. 2003, 6:422-431.
17. Ophoff R.A., et al. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 1996, 87:543-552.
18. Pietrobon D., Moskowitz M.A. Pathophysiology of migraine. Annu. Rev. Physiol. 2013, 75:365-391.
19. Purcell S., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 2007, 81:559-575.
20. Sano Y., et al. A novel two-pore domain K+channel, TRESK, is localized in the spinal cord. J. Biol. Chem. 2003, 278:27406-27412.
21. Stewart W.F., Bigal M.E., Kolodner K., Dowson A., Liberman J.N., Lipton R.B. Familial risk of migraine: variation by proband age at onset and headache severity. Neurology 2006, 66:344-348.
22. Suzuki M., et al. Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:15963-15968.
23. van den Maagdenberg A.M., et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron 2004, 41:701-710.
24. Yoo S., Liu J., Sabbadini M., Au P., Xie G.X., Yost C.S. Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system. Neurosci. Lett. 2009, 465:79-84.