Heat shock protein expression analysis in canine osteosarcoma reveals HSP60 as a potentially relevant therapeutic target

Cell Stress and Chaperones

Volumn 18, Issue 5, 2013, Pages 607-622

  Selvarajah, Gayathri T ^a,b   Bonestroo, Floor A S ^a   Kirpensteijn, Jolle ^a   Kik, Marja J L ^c   Van Der Zee, Ruurd ^c   Van Eden, Willem ^c   Timmermans Sprang, Elpetra P M ^a   Slob, Adri ^a   Mol, Jan A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Dog; Heat shock proteins (HSP); Osteosarcoma

Indexed keywords

CHAPERONIN 60; EARLY PREGNANCY FACTOR; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 22; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90ALPHA; HEAT SHOCK PROTEIN 90BETA; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CELL PROLIFERATION; CONTROLLED STUDY; DOG DISEASE; DRUG TARGETING; EARLY PREGNANCY FACTOR GENE; FEMALE; GENE EXPRESSION; HEAT SHOCK PROTEIN 22 GENE; HEAT SHOCK PROTEIN 27 GENE; HEAT SHOCK PROTEIN 40 GENE; HEAT SHOCK PROTEIN 70 GENE; HEAT SHOCK PROTEIN 90ALPHA GENE; HEAT SHOCK PROTEIN 90BETA GENE; HSP60 GENE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; WESTERN BLOTTING;

CANIS FAMILIARIS; EUKARYOTA; PROKARYOTA;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CHAPERONIN 60; DOGS; FEMALE; HEAT-SHOCK PROTEINS; HEAT-SHOCK RESPONSE; IMMUNOHISTOCHEMISTRY; MALE; OSTEOSARCOMA; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84883054423     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-013-0414-2     Document Type: Article

References (45)

1. Akyol S, Gercel-Taylor C, Reynolds LC, Taylor DD (2006) HSP-10 in ovarian cancer: expression and suppression of T-cell signaling. Gynecol Oncol. doi: 10.1016/j.ygyno.2005.11.014
2. Benndorf R, Sun X, Gilmont RR, Biederman KJ, Molloy MP, Goodmurphy CW, Cheng H, Andrews PC, Welsh MJ (2001) HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27). J Biol Chem. doi: 10.1074/jbc.M103001200
3. Burel C, Mezger V, Pinto M, Rallu M, Trigon S, Morange M (1992) Mammalian heat shock protein families. Expression and functions. Experientia
4. Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR (2006) Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci. doi: 10.1016/j.tibs.2006.01.006
5. Cappello F, Conway de Macario E, Marasa L, Zummo G, Macario AJ (2008) Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy. Cancer Biol Ther
6. Cappello F, David S, Rappa F, Bucchieri F, Marasa L, Bartolotta TE, Farina F, Zummo G (2005) The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase. BMC Cancer. doi: 10.1186/1471-2407-5-139
7. Cappello F (2003) HSP60 and HSP10 as diagnostic and prognostic tools in the management of exocervical carcinoma. Gynecol Oncol
8. Cappello F, Rappa F, David S, Anzalone R, Zummo G (2003) Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis. Anticancer Res
9. Chandra D, Choy G, Tang DG (2007) Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3. J Biol Chem. doi: 10.1074/jbc.M702777200
10. Chu RM, Sun TJ, Yang HY, Wang DG, Liao KW, Chuang TF, Lin CH, Lee WC (2001) Heat shock proteins in canine transmissible venereal tumor. Vet Immunol Immunopathol
11. Faried A, Sohda M, Nakajima M, Miyazaki T, Kato H, Kuwano H (2004) Expression of heat-shock protein Hsp60 correlated with the apoptotic index and patient prognosis in human oesophageal squamous cell carcinoma. Eur J Cancer. doi: 10.1016/j.ejca.2004.08.013
12. Garzotto CK, Berg J, Hoffmann WE, Rand WM (2000) Prognostic significance of serum alkaline phosphatase activity in canine appendicular osteosarcoma. J Vet Intern Med
13. Hartl FU, Hayer-Hartl M (2002) Molecular chaperones in the cytosol: from nascent chain to folded protein. Science. doi: 10.1126/science.1068408
14. Helmbrecht K, Zeise E, Rensing L (2000) Chaperones in cell cycle regulation and mitogenic signal transduction: a review. Cell Prolif
15. Hendrick JP, Hartl FU (1993) Molecular chaperone functions of heat-shock proteins. Annu Rev Biochem. doi: 10.1146/annurev.bi.62.070193.002025
16. Kampinga HH, Hageman J, Vos MJ, Kubota H, Tanguay RM, Bruford EA, Cheetham ME, Chen B, Hightower LE (2009) Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones. doi: 10.1007/s12192-008-0068- 7
17. Kaul Z, Yaguchi T, Kaul SC, Wadhwa R (2006) Quantum dot-based protein imaging and functional significance of two mitochondrial chaperones in cellular senescence and carcinogenesis. Ann N Y Acad Sci
18. Kirpensteijn J, Kik M, Teske E, Rutteman GR (2008) TP53 gene mutations in canine osteosarcoma. Vet Surg
19. Kirpensteijn J, Kik M, Rutteman GR, Teske E (2002) Prognostic significance of a new histologic grading system for canine osteosarcoma. Vet Pathol
20. Kumaraguruparan R, Karunagaran D, Balachandran C, Manohar BM, Nagini S (2006) Of humans and canines: a comparative evaluation of heat shock and apoptosis-associated proteins in mammary tumors. Clin Chim Acta. doi: 10.1016/j.cca.2005.08.018
21. Levine RA, Forest T, Smith C (2002) Tumor suppressor PTEN is mutated in canine osteosarcoma cell lines and tumors. Vet Pathol
22. McCleese JK, Bear MD, Fossey SL, Mihalek RM, Foley KP, Ying W, Barsoum J, London CA (2009) The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines. Int J Cancer. doi: 10.1002/ijc.24660
23. Misdorp W, Hart AA (1979) Some prognostic and epidemiologic factors in canine osteosarcoma. J Natl Cancer Inst
24. Mitra A, Shevde LA, Samant RS (2009) Multi-faceted role of HSP40 in cancer. Clin Exp Metastasis. doi: 10.1007/s10585-009-9255-x
25. Moon A, Bacchini P, Bertoni F, Olvi LG, Santini-Araujo E, Kim YW, Park YK (2010) Expression of heat shock proteins in osteosarcomas. Pathology. doi: 10.3109/00313025.2010.493866
26. Morello E, Martano M, Buracco P (2010) Biology, diagnosis and treatment of canine appendicular osteosarcoma: Similarities and differences with human osteosarcoma. Vet J. doi: 10.1016/j.tvjl.2010.08.014
27. Morii T, Ohtsuka K, Ohnishi H, Mochizuki K, Satomi K (2010) Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid. Anticancer Res
28. Norrdin RW, Powers BE, Torgersen JL, Smith RE, Withrow SJ (1989) Characterization of osteosarcoma cells from two sibling large-breed dogs. Am J Vet Res
29. Pace A, Barone G, Lauria A, Martorana A, Piccionello AP, Pierro P, Terenzi A, Almerico AM, Buscemi S, Campanella C, Angileri F, Carini F, Zummo G, de Macario EC, Cappello F, Macario AJ (2012) Hsp60, a novel target for antitumor therapy: Structure-function features and prospective drugs design. Curr Pharm Des
30. Paoloni M, Davis S, Lana S, Withrow S, Sangiorgi L, Picci P, Hewitt S, Triche T, Meltzer P, Khanna C (2009) Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. BMC Genomics. doi: 10.1186/1471-2164-10-625
31. Romanucci M, D'Amato G, Malatesta D, Bongiovanni L, Palmieri C, Ciccarelli A, Buracco P, Morello E, Maniscalco L, De Maria R, Martano M, Della Salda L (2012) Heat shock protein expression in canine osteosarcoma. Cell Stress Chaperones. doi: 10.1007/s12192-011-0294-2
32. Romanucci M, Bastow T, Della Salda L (2008) Heat shock proteins in animal neoplasms and human tumours - a comparison. Cell Stress Chaperones. doi: 10.1007/s12192-008-0030-8
33. Romanucci M, Marinelli A, Sarli G, Della Salda L (2006) Heat shock protein expression in canine malignant mammary tumours. BMC Cancer. doi: 10.1186/1471-2407-6-171
34. Romanucci M, Bongiovanni L, Marruchella G, Mara M, di Guardo G, Preziosi R, della Salda L (2005) Heat shock proteins expression in canine intracutaneous cornifying epithelioma and squamous cell carcinoma. Vet Dermatol. doi: 10.1111/j.1365-3164.2005.00436.x
35. Ru G, Terracini B, Glickman LT (1998) Host related risk factors for canine osteosarcoma. Vet J
36. Samali A, Cai J, Zhivotovsky B, Jones DP, Orrenius S (1999) Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO J. doi: 10.1093/emboj/18.8.2040
37. Selvarajah GT, Kirpensteijn J (2010) Prognostic and predictive biomarkers of canine osteosarcoma. Vet J. doi: 10.1016/j.tvjl.2010.04.010
38. Selvarajah GT, Kirpensteijn J, van Wolferen ME, Rao NA, Fieten H, Mol JA (2009) Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. Mol Cancer. doi: 10.1186/1476-4598-8-72
39. Sun X, Fontaine JM, Bartl I, Behnam B, Welsh MJ, Benndorf R (2007) Induction of Hsp22 (HspB8) by estrogen and the metalloestrogen cadmium in estrogen receptor-positive breast cancer cells. Cell Stress Chaperones
40. Trieb K, Gerth R, Holzer G, Grohs JG, Berger P, Kotz R (2000a) Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy. Br J Cancer. doi: 10.1054/bjoc.1999.0881
41. Trieb K, Gerth R, Windhager R, Grohs JG, Holzer G, Berger P, Kotz R (2000b) Serum antibodies against the heat shock protein 60 are elevated in patients with osteosarcoma. Immunobiology
42. Trieb K, Lechleitner T, Lang S, Windhager R, Kotz R, Dirnhofer S (1998) Heat shock protein 72 expression in osteosarcomas correlates with good response to neoadjuvant chemotherapy. Hum Pathol
43. Uozaki H, Ishida T, Kakiuchi C, Horiuchi H, Gotoh T, Iijima T, Imamura T, Machinami R (2000) Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. Pathol Res Pract
44. Uozaki H, Horiuchi H, Ishida T, Iijima T, Imamura T, Machinami R (1997) Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis. Cancer
45. Wolf M, El-Rifai W, Tarkkanen M, Kononen J, Serra M, Eriksen EF, Elomaa I, Kallioniemi A, Kallioniemi OP, Knuutila S (2000) Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. Cancer Genet Cytogenet